Therapies for Children with Autism Spectrum Disorders [Entered Retrospectively]

Project Summary Title and Description

Title
Therapies for Children with Autism Spectrum Disorders [Entered Retrospectively]
Description
The Vanderbilt Evidence-based Practice Center systematically reviewed evidence on therapies for children ages 2 to 12 with autism spectrum disorders (ASDs). We focused on treatment outcomes, modifiers of treatment effectiveness, evidence for generalization of outcomes to other contexts, and evidence to support treatment decisions in children ages 0-2 at risk for an ASD diagnosis.
Attribution
N/A
Authors of Report
N/A
Methodology description
We included studies published in English from January 2000 to May 2010. We excluded medical studies with fewer than 30 participants; behavioral, educational, and allied health studies with fewer than 10 participants; and studies lacking relevance to treatment for ASDs.
PROSPERO
N/A
DOI
10.7301/Z01Z429D
Notes
*** The systematic review data of this published project was retrospectively imported into SRDR by the Brown EPC on behalf of the Vanderbilt Evidence-based Practice Center and the Agency for Healthcare Research and Quality (AHRQ). For access to the full report available on the AHRQ website, follow this link: http://effectivehealthcare.ahrq.gov/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productID=656 *** This systematic review of the literature will address the following key questions: KQ 1: Among children ages 2-12 with ASDs, what are the short- and long-term effects of available behavioral, educational, family, medical, allied health, or CAM treatment approaches? Specifically, KQ 1a: What are the effects on core symptoms (e.g., social deficits, communication deficits, and repetitive behaviors) in the short term (< = 6 months)? KQ 1b: What are the effects on commonly associated symptoms (e.g., motor, sensory, medical, mood/anxiety, irritability, and hyperactivity) in the short term (< = 6 months)? KQ 1c: What are the longer term effects (>6 months) on core symptoms (e.g., social deficits, communication deficits, and repetitive behaviors)? KQ 1d: What are the longer term effects (>6 months) on commonly associated symptoms (e.g., motor, sensory, medical, mood/anxiety, irritability, and hyperactivity)? KQ 2: Among children ages 2-12, what are the modifiers of outcome for different treatments or approaches? KQ 2a: Is the effectiveness of the therapies reviewed affected by the frequency, duration, and intensity of the intervention? KQ 2b: Is the effectiveness of the therapies reviewed affected by the training and/or experience of the individual providing the therapy? KQ 2c: What characteristics, if any, of the child modify the effectiveness of the therapies reviewed? KQ 2d: What characteristics, if any, of the family modify the effectiveness of the therapies reviewed? KQ 3: Are there any identifiable changes early in the treatment phase that predict treatment outcomes? KQ 4: What is the evidence that effects measured at the end of the treatment phase predict long- term functional outcomes? KQ 5: What is the evidence that specific intervention effects measured in the treatment context generalize to other contexts (e.g., people, places, materials)? KQ 6: What evidence supports specific components of treatment as driving outcomes, either within a single treatment or across treatments? KQ 7: What evidence supports the use of a specific treatment approach in children under the age of 2 who are at high risk of developing autism based upon behavioral, medical, or genetic risk factors? | Abbreviations for Appendix G - Table 1: AAC- augmentative and alternative communication; ASD-autism spectrum disorders; EIBI-early intensive behavioral intervention; PECS-Picture Exchange Communication System; RPMT- Responsive Education and Prelinguistic Milieu Teaching; td-treatment |
Funding Source
The Agency for Healthcare Research and Quality (AHRQ)

Key Questions

1. Key Question 1 - Therapies for children with ASD
2. Key Question 2 - Characteristics of recent systematic reviews

Associated Extraction Forms

Associated Studies (each link opens a new tab)

TitleAuthorsYear
Early intensive behavioral intervention: outcomes for children with autism and their parents after two years.2007
Cognitive, behavior and intervention outcome in young children with autism.2008
Brief report: relative effectiveness of different home-based behavioral approaches to early teaching intervention.2007
Early intensive behavioral treatment: replication of the UCLA model in a community setting.2006
Effects of low-intensity behavioral treatment for children with autism and mental retardation.2006
A controlled trial of a training course for parents of children with suspected autism spectrum disorder.2005
Concurrent validity of social subtype and IQ after early intensive behavioral intervention in children with autism: a preliminary investigation.2005
A new social communication intervention for children with autism: pilot randomised controlled reatment study suggesting effectiveness.2004
A pilot randomised control trial of a parent training intervention for pre-school children with autism. Preliminary findings and methodological challenges.2002
Outcome survey of early intensive behavioral intervention for young children with autism in a community setting.2001
Group Intensive Family Training (GIFT) for preschoolers with autism spectrum disorders.2008
Parent education and home-based behaviour analytic intervention: An examination of parents' perceptions of outcome.2004
Designing an outcome study to monitor the progress of students with autism spectrum disorders.2003
The effects of an accelerated parent education program on technique mastery and child outcome.2001
Home-based behavioral interventions for young children with autism/pervasive developmental disorder: A preliminary evaluation of outcome in relation to child age and intensity of service delivery.2000
Effectiveness of Intensive Behavioral Intervention in a Large, Community-Based Program.2008
Stability of adaptive behaviors in middle- school children with autism spectrum disorders.2007
Change in Autism core symptoms with early intervention: predictors and outcomes.2009
Early social interaction project for children with autism spectrum disorders beginning in the second year of life: a preliminary study.2006
Change in autism core symptoms with intervention.2007
Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model.2010
Retrospective analysis of clinical records in 38 cases of recovery from autism.2009
A pilot study of the effects of a social-pragmatic intervention on the communication and symbolic play of children with autism.2007
A comparison of intensive behavior analytic and eclectic treatments for young children with autism.2005
An exploratory evaluation of two early intervention programmes for young children with autism.2005
Dissemination of Evidence-Based Practice: Can We Train Therapists from a Distance?2009
Progress and outcomes for children with autism receiving parent-managed intensive interventions.2002
Outcome for children with autism who began intensive behavioral treatment between ages 4 and 7: a comparison controlled study.2007
Parent-mediated communication-focused treatment in children with autism (PACT): a randomised controlled trial.2010
LEGO therapy and the social use of language programme: an evaluation of two social skills interventions for children with high functioning autism and Asperger Syndrome.2008
Social competence and social skills training and intervention for children with Autism Spectrum Disorders.2009
Social stories: mechanisms of effectiveness in increasing game play skills in children diagnosed with autism spectrum disorder using a pretest posttest repeated measures randomized control group design.2009
A multi- component social skills intervention for children with Asperger syndrome: the Junior Detective Training Program.2008
Effectiveness of a manualized summer social treatment program for high- functioning children with autism spectrum disorders.2008
A social adjustment enhancement intervention for high functioning autism, Asperger's syndrome, and pervasive developmental disorder NOS.2004
A Comparison of Two Group-Delivered Social Skills Programs for Young Children with Autism.2007
A Randomized Controlled Study of Parent- assisted Children's Friendship Training with Children having Autism Spectrum Disorders.2010
Brief report: individual social-multi-modal intervention for HFASD.2007
Brief report: A theory-of-mind-based social- cognition training program for school-aged children with pervasive developmental disorders: an open study of its effectiveness.2006
The impact of group psychotherapy on social development in children with pervasive development disorders.2008
Effectiveness of a cognitive-behavioral treatment on the social behaviors of children with Asperger Disorder.2006
Fostering Communication and Shared Play between Mainstream Peers and Children with Autism: Approaches, Outcomes and Experiences.2004
Long-term outcome of social skills intervention based on interactive LEGO play.2006
Enhancing Emotion Recognition in Children with Autism Spectrum Conditions: An Intervention Using Animated Vehicles with Real Emotional Faces.2010
A double-blind, placebo-controlled trial of oral human immunoglobulin for gastrointestinal dysfunction in children with autistic disorder.2009
Language outcome in autism: randomized comparison of joint attention and play interventions.2008
Children with autism's response to novel stimuli while participating in interventions targeting joint attention or symbolic play skills.2007
The acquisition and generalization of joint attention and symbolic play skills in young children with autism.2007
Evaluation of the relationship development intervention program.2007
Pilot Study of a parent training program for young children with autism: The PLAY Project Home Consultation Program.2007
The effectiveness of parent-child interaction therapy for families of children on the autism spectrum.2008
Retrospective evaluation of an intensive method of treatment for children with pervasive developmental disorder.2007
Imitative interaction increases social interest and elicited imitation in non-verbal children with autism.2006
Brief report: Imitation effects on children with autism.2002
Relationship-focused early intervention with children with pervasive developmental disorders and other disabilities: a comparative study.2005
The co- regulation of emotions between mothers and their children with autism.2010
A randomized controlled trial of a cognitive behavioural intervention for anger management in children diagnosed with Asperger syndrome.2007
A randomised controlled trial of a CBT intervention for anxiety in children with Asperger syndrome.2005
Brief Report: Effects of Cognitive Behavioral Therapy on Parent-Reported Autism Symptoms in School-Age Children with High-Functioning Autism.2009
Cognitive-behavioral group treatment for anxiety symptoms in children with high- functioning autism spectrum disorders: a pilot study.2009
Parent training for children with pervasive developmental disorders: A multi-site feasibility trial.2007
Treating anxiety disorders in children with high functioning autism spectrum disorders: a controlled trial.2007
Evaluating the effectiveness of teacher training in Applied Behaviour Analysis.2005
Parent management training and Asperger syndrome: a randomized controlled trial to evaluate a parent based intervention.2004
The effectiveness of parent management training to increase self-efficacy in parents of children with Asperger syndrome.2002
Therapy intervention for anxiety in children with Asperger's syndrome.2003
Medication and parent training in children with pervasive developmental disorders and serious behavior problems: results from a randomized clinical trial.2009
Efficacy of neurofeedback for children in the autistic spectrum: a pilot study.2002
Assessment-guided neurofeedback for autistic spectrum disorder.2007
Parent-based sleep education workshops in autism.2009
Brief report: outcomes of a teacher training program for autism spectrum disorders.2008
Brief report: application of the TEACCH program on Chinese pre-school children with autism does culture make a difference?2007
Psychoeducational treatment of children with autism and reactive attachment disorder.2004
Special education versus inclusive education: the role of the TEACCH program.2009
A randomized, controlled trial of a home-based intervention program for children with autism and developmental delay.2007
The Scottish Centre for Autism preschool treatment programme. II: The results of a controlled treatment outcome study.2002
Parenting stress reduces the effectiveness of early teaching interventions for autistic spectrum disorders.2008
A two- year prospective follow-up study of community-based early intensive behavioural intervention and specialist nursery provision for children with autism spectrum disorders.2007
The real- world effectiveness of early teaching interventions for children with autism spectrum disorder.2007
Cognitive, behavior and intervention outcome in young children with autism.2007
Effectiveness of special nursery provision for children with autism spectrum disorders.2010
Starting off on the right foot: one year of behavior analysis in practice and relative cost.2008
Brief report: vocabulary acquisition for children with autism: teacher or computer instruction.2000
Efficacy of TeachTown: Basics computer-assisted intervention for the Intensive Comprehensive Autism Program in Los Angeles Unified School District.2010
Interaction patterns between children and their teachers when using a specific multimedia and communication strategy: observations from children with autism and mixed intellectual disabilities.2001
Acute and long-term safety and tolerability of risperidone in children with autism.2008
Parent-defined target symptoms respond to risperidone in RUPP autism study: customer approach to clinical trials2005
Age and IQ at intake as predictors of placement for young children with autism: a four- to six-year follow-up.2000
Child Demographics Associated With Outcomes in a Community-Based Pivotal Response Training Program.2007
Risperidone in the treatment of disruptive behavioral symptoms in children with autistic and other pervasive developmental disorders.2004
Risperidone in children with autism: randomized, placebo- controlled, double-blind study.2006
A 3- year naturalistic study of 53 preschool children with pervasive developmental disorders treated with risperidone.2003
A placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorder.2009
Aripiprazole in the treatment of irritability in children and adolescents with autistic disorder.2009
Cyproheptadine in the treatment of autistic dosorder: a double-blind placebo-controlled trial.2004
Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions.2009
A placebo controlled crossover trial of liquid fluoxetine on repetitive behaviors in childhood and adolescent autism.2005
Assessing progress during treatment for young children with autism receiving intensive behavioural interventions.2009
Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: citalopram ineffective in children with autism.2009
Multisite, double-blind, placebo-controlled trial of porcine secretin in autism.2010
Treatment outcome and outcome associations in children with pervasive developmental disorders treated with selective serotonin reuptake inhibitors: a chart review.2006
Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures.2007
Stimulant medication treatment of target behaviors in children with autism: a population-based study.2008
Guanfacine treatment of hyperactivity and inattention in pervasive developmental disorders: a retrospective analysis of 80 cases.2004
A naturalistic retrospective analysis of psychostimulants in pervasive developmental disorders.2004
Children with autistic spectrum disorders. I: comparison of placebo and single dose of human synthetic secretin.2003
Lack of benefit of intravenous synthetic human secretin in the treatment of autism.2002
A randomized, double-blind, placebo- controlled trial of porcine versus synthetic secretin for reducing symptoms of autism.2002
Multisite, double-blind, placebo-controlled trial of porcine secretin in autism.2001
Repeated doses of porcine secretin in the treatment of autism: a randomized, placebo- controlled trial.2001
A randomized, double-blind, placebo- controlled trial of single-dose intravenous secretin as treatment for children with autism.2001
Effect of secretin on children with autism: a randomized controlled trial.2000
Secretin and autism: a two-part clinical investigation.2000
A double-blind placebo controlled trial of piracetam added to risperidone in patients with autistic disorder.2008
Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders.2002
Double-blind, placebo-controlled study of amantadine hydrochloride in the treatment of children with autistic disorder.2001
Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder.2001
Donepezil hydrochloride: A double-blind study in autistic children. Journal of Pediatric Neurology.2003
Hyperbaric treatment for children with autism: a multicenter, randomized, double- blind, controlled trial.2009
Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: part Amedical results.2009
Melatonin for insomnia in children with autism spectrum disorders.2008
Role of polyunsaturated fatty acids in the management of Egyptian children with autism.2008
Children with autism: effect of iron supplementation on sleep and ferritin.2007
Improvement of neurobehavioral disorders in children supplemented with magnesium- vitamin B6. II.2006
Treating autistic spectrum disorders in children: utility of the cholinesterase inhibitor rivastigmine tartrate.2004
Application of a ketogenic diet in children with autistic behavior: pilot study.2003
Digestive enzyme supplementation for autism spectrum disorders: a double-blind randomized controlled trial.2010
Double-blind placebo-controlled trial of pentoxifylline added to risperidone: Effects on aberrant behavior in children with autism.2010
Predicting lexical density growth rate in young children with autism spectrum disorders.2006
Brief Report: randomized test of the efficacy of Picture Exchange Communication System on highly generalized picture exchanges in children with ASD.2010
The effects of PECS teaching to Phase III on the communicative interactions between children with autism and their teachers.2007
The effectiveness of Picture Exchange Communication System (PECS) training for teachers of children with autism: a pragmatic, group randomised controlled trial.2007
A pilot evaluation study of the Picture Exchange Communication System (PECS) for children with autistic spectrum disorders.2003
Teaching picture-to-object relations in picture-based requesting by children with autism: a comparison between error prevention and error correction teaching procedures.2008
A sensory integration therapy program on sensory problems for children with autism.2008
Efficacy of sensory integration treatment based on virtual realitytangible interaction for children with autism.2006
Brief Report: Effects of Cognitive Behavioral Therapy on Parent-Reported Autism Symptoms in School-Age Children with High-Functioning Autism.2009
Auditory integration training for children with autism: no behavioral benefits detected.2000
Brief report: the effects of Tomatis sound therapy on language in children with autism.2008
Emotional, motivational and interpersonal responsiveness of children with autism in improvisational music therapy.2009
Occupational therapy incorporating animals for children with autism: A pilot investigation.2006
Spatial orientation adjustments in children with autism in Hong Kong.2001
Creative movement therapy benefits children with autism.2001
Colored Overlays Enhance Visual Perceptual Performance in Children with Autism Spectrum Disorders.2008
The effect of therapeutic horseback riding on social functioning in children with autism.2009
The effect of coloured overlays on reading ability in children with autism.2006
Treatment outcomes for severe feeding problems in children with autism spectrum disorder.2009
Effects of water exercise swimming program on aquatic skills and social behaviors in children with autism spectrum disorders.2010
Effects of Thai traditional massage on autistic children's behavior.2009
Scalp acupuncture effect on language development in children with autism: a pilot study.2008
Seven- star needle stimulation improves language and social interaction of children with autistic spectrum disorders.2009
Outcomes of a pilot training program in a qigong massage intervention for young children with autism.2008
Improvement in sensory impairment and social interaction in young children with autism following treatment with an original Qigong massage methodology.2007
Brief report: improvements in the behavior of children with autism following massage therapy.2001
Qigong massage treatment for sensory and self-regulation problems in young children with autism: a randomized controlled trial.2009
Intensive behavioral treatment for children with autism: four-year outcome and predictors.2005
Inclusive Programming for Toddlers with Autism Spectrum Disorders: Outcomes from the Childrens Toddler School.2004
Fluoxetine response in children with autistic spectrum disorders: correlation with familial major affective disorder and intellectual achievement.2002
-- No Title Entered --2009
-- No Title Entered --2000
Effectiveness of the Picture Exchange Communication System (PECS) on communication and speech for children with autism spectrum disorders: a meta-analysis.2010
Gluten-Free and Casein-Free Diets in the Treatment of Autism Spectrum Disorders: A Systematic Review. Research in Autism Spectrum Disorders2010
Meta-analysis of Early Intensive Behavioral Intervention for children with autism.2009
Autism.2008
Comprehensive synthesis of early intensive behavioral interventions for young children with autism based on the UCLA young autism project model.2009
Evidence-based comprehensive treatments for early autism.2008
Efficacy of applied behavioral intervention in preschool children with autism for improving cognitive, language, and adaptive behavior: a systematic review and meta-analysis.2009
Special report: early intensive behavioral intervention based on applied behavior analysis among children with autism spectrum disorders.2009
Effects of augmentative and alternative communication intervention on speech production in children with autism: a systematic review.2008
Gluten- and casein-free diets for autistic spectrum disorder.2008

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