Safety of Vaccines Used for Routine Immunization in the United States: An Update

Project Summary Title and Description

Title
Safety of Vaccines Used for Routine Immunization in the United States: An Update
Description
Objective. To conduct a systematic review of the literature on the safety of vaccines recommended for routine immunization in the United States, updating the 2014 Agency for Healthcare Research and Quality (AHRQ) report on the topic. Data sources. We searched MEDLINE®, Embase®, CINAHL®, Cochrane CENTRAL, Web of Science, and Scopus through November 9, 2020, building on the prior 2014 report; reviewed existing reviews, trial registries, and supplemental material submitted to AHRQ; and consulted with experts. Review methods. This report addressed three Key Questions (KQs) on the safety of vaccines currently in use in the United States and included in the Centers for Disease Control and Prevention’s (CDC) recommended immunization schedules for adults (KQ1), children and adolescents (KQ2), and pregnant women (KQ3). The systematic review was supported by a Technical Expert Panel that identified key adverse events of particular concern. Two reviewers independently screened publications; data were extracted by an experienced subject matter expert. Studies of vaccines that used a comparator and reported the presence or absence of adverse events were eligible. We documented observed rates and assessed the relative risks for key adverse events. We assessed the strength of evidence (SoE) across the existing findings from the prior 2014 report and the new evidence from this update. The systematic review is registered in PROSPERO (CRD42020180089). Results. A large body of evidence is available to evaluate adverse events following vaccination. Of 56,608 reviewed citations, 189 studies met inclusion criteria for this update, adding to data in the prior 2014 report, for a total of 338 included studies reported in 518 publications. Regarding vaccines recommended for adults (KQ1), we found either no new evidence of increased risk for key adverse events with varied SoE or insufficient evidence in this update, including for newer vaccines such as recombinant influenza vaccine, adjuvanted inactivated influenza vaccine, and recombinant adjuvanted zoster vaccine. The prior 2014 report noted a signal for anaphylaxis for hepatitis B vaccines in adults with yeast allergy and for tetanus, diphtheria, and acellular pertussis vaccines. Regarding vaccines recommended for children and adolescents (KQ2), we found either no new evidence of increased risk for key adverse events with varied SoE or insufficient evidence, including for newer vaccines such as 9-valent human papillomavirus vaccine and meningococcal B vaccine. The prior 2014 report noted signals for rare adverse events—such as anaphylaxis, idiopathic thrombocytopenic purpura, and febrile seizures—with some childhood vaccines. Regarding vaccines recommended for pregnant women (KQ3), we found no evidence of increased risk for key adverse events with varied SoE among either pregnant women or their infants following administration of tetanus, diphtheria, and acellular pertussis vaccines during pregnancy. Conclusion. Across this large body of research, we found no new evidence of increased risk since the prior 2014 report for key adverse events following administration of vaccines that are routinely recommended. Signals from the prior report remain unchanged for rare adverse events, which include anaphylaxis in adults and children, and febrile seizures and idiopathic thrombocytopenic purpura in children. There is no evidence of increased risk of adverse events for vaccines currently recommended in pregnant women. There remains insufficient evidence to draw conclusions about some rare potential adverse events.
Attribution
N/A
Authors of Report
N/A
Methodology description
Systematic Review
PROSPERO
CRD42020180089
DOI
N/A
Notes
Report can be found here: https://pubmed.ncbi.nlm.nih.gov/34279864/ and https://effectivehealthcare.ahrq.gov/products/safety-vaccines/research Data was entered into this project prospectively
Funding Source
Agency for Healthcare Research and Quality

Key Questions

1. Key Question 1: What is the evidence that vaccines included in the immunization schedule recommended for adults in the United States (https://www.cdc.gov/vaccines/schedules/hcp/imz/adult.html) are safe in the short term (within 42 days following immunization) or long term (>42 days after immunization)?
2. Key Question 2: What is the evidence that vaccines included in the immunization schedules recommended for children and adolescents in the United States (https://www.cdc.gov/vaccines/schedules/hcp/imz/child-adolescent.html) are safe in the short term (within 42 days following immunization) or long term (>42 days after immunization)?
3. Key Question 3: What is the evidence that vaccines recommended for pregnant women, in the United States are safe in the short term (within 42 days following immunization) or long term (>42 days after immunization) for both the woman and her fetus/infant?

Associated Extraction Forms

Type
Standard

Associated Studies (each link opens a new tab)

Title Authors Year
Measles-mumps-rubella-varicella combination vaccine and the risk of febrile seizures N. P. Klein, B. Fireman, W. K. Yih, E. Lewis, M. Kulldorff, P. Ray, R. Baxter, S. Hambidge, J. Nordin, A. Naleway, E. A. Belongia, T. Lieu, J. Baggs, E. Weintraub, D. Vaccine Safety 2010
Additive benefits of pneumococcal and influenza vaccines among elderly persons aged 75 years or older in Taiwan - A representative population-based comparative study Y. C. Chang, Y. J. Chou, J. Y. Liu, T. F. Yeh, N. Huang 2012
Immunogenicity and safety of a quadrivalent live attenuated influenza vaccine in children S. L. Block, J. Falloon, J. A. Hirschfield, L. R. Krilov, F. Dubovsky, T. Yi, R. B. Belshe 2012
A randomized, double-blind noninferiority study of quadrivalent live attenuated influenza vaccine in adults S. L. Block, T. Yi, E. Sheldon, F. Dubovsky, J. Falloon 2011
Prevention of acute myocardial infarction and stroke among elderly persons by dual pneumococcal and influenza vaccination: a prospective cohort study I. F. N. Hung, A. Y. M. Leung, D. W. S. Chu, D. Leung, T. Cheung, C.-K. Chan, C. L. K. Lam, S.-H. Liu, C.-M. Chu, P.-L. Ho, S. Chan, T.-H. Lam, R. Liang, K.-Y. Yuen 2010
A randomized, double-blind trial to evaluate immunogenicity and safety of 13-valent pneumococcal conjugate vaccine given concomitantly with trivalent influenza vaccine in adults aged >=65 years T. F. Schwarz, J. Flamaing, H. C. Rumke, J. Penzes, C. Juergens, A. Wenz, D. Jayawardene, P. Giardina, E. A. Emini, W. C. Gruber, B. Schmoele-Thoma 2011
Immunogenicity and tolerability of a quadrivalent meningococcal glycoconjugate vaccine in children 2-10 years of age S. Black, N. P. Klein, J. Shah, L. Bedell, A. Karsten, P. M. Dull 2010
Immunogenicity and tolerability of a multicomponent meningococcal serogroup B (4CMenB) vaccine in healthy adolescents in Chile: a phase 2b/3 randomised, observer-blind, placebo-controlled study M. E. Santolaya, M. L. O'Ryan, M. T. Valenzuela, V. Prado, R. Vergara, A. Munoz, D. Toneatto, G. Grana, H. Wang, R. Clemens, P. M. Dull, V. P. M. B. A. V. S. group 2012
Effectiveness of MF59-adjuvanted subunit influenza vaccine in preventing hospitalisations for cardiovascular disease, cerebrovascular disease and pneumonia in the elderly J. Puig-Barbera, J. Diez-Domingo, A. B. Varea, G. S. Chavarri, J. A. L. Rodrigo, S. P. Hoyos, D. G. Vidal 2007
Safety, immunogenicity, and tolerability of meningococcal serogroup B bivalent recombinant lipoprotein 2086 vaccine in healthy adolescents: A randomised, single-blind, placebo-controlled, phase 2 trial P. C. Richmond, H. S. Marshall, M. D. Nissen, Q. Jiang, K. U. Jansen, M. Garces-Sanchez, F. Martinon-Torres, J. Beeslaar, L. Szenborn, J. Wysocki, J. Eiden, S. L. Harris, T. R. Jones, J. L. Perez 2012
Efficacy of human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in European infants: randomised, double-blind controlled study T. Vesikari, A. Karvonen, R. Prymula, V. Schuster, J. Tejedor, R. Cohen, F. Meurice, H. Han, S. Damaso, A. Bouckenooghe 2007
Adapting group sequential methods to observational postlicensure vaccine safety surveillance: results of a pentavalent combination DTaP-IPV-Hib vaccine safety study J. C. Nelson, O. Yu, C. P. Dominguez-Islas, A. J. Cook, D. Peterson, S. K. Greene, W. K. Yih, M. F. Daley, S. J. Jacobsen, N. P. Klein, E. S. Weintraub, K. R. Broder, L. A. Jackson 2013
Immunogenicity and safety of 13-valent pneumococcal conjugate vaccine given to korean children receiving routine pediatric vaccines D. S. Kim, S. H. Shin, H. J. Lee, Y. J. Hong, S. Y. Lee, K. M. Choi, C. E. Oh, K. H. Kim, C. Juergens, S. Patterson, P. C. Giardina, W. C. Gruber, E. A. Emini, D. A. Scott 2013
Immunogenicity and safety of quadrivalent versus trivalent inactivated influenza vaccine: a randomized, controlled trial in adults J. Beran, M. Peeters, W. Dewe, J. Raupachova, L. Hobzova, J. M. Devaster 2013
A Randomized Trial of Candidate Inactivated Quadrivalent Influenza Vaccine versus Trivalent Influenza Vaccines in Children Aged 3-17 Years J. B. Domachowske, H. Pankow-Culot, M. Bautista, Y. Feng, C. Claeys, M. Peeters, B. L. Innis, V. Jain 2013
Randomized, controlled trial of a 13-valent pneumococcal conjugate vaccine administered concomitantly with an influenza vaccine in healthy adults R. W. Frenck, Jr., A. Gurtman, J. Rubino, W. Smith, M. van Cleeff, D. Jayawardene, P. C. Giardina, E. A. Emini, W. C. Gruber, D. A. Scott, and B. Schmole-Thoma 2012
Safety and immunogenicity of a hexavalent vaccine administered at 2, 4 and 6 months of age with or without a heptavalent pneumococcal conjugate vaccine: a randomized, open-label study B. Tapiero, S. A. Halperin, M. Dionne, W. Meekison, F. Diaz-Mitoma, P. Zickler, E. Rubin, J. Embree, P. Bhuyan, A. W. Lee, M. Li, A. Tomovici 2013
Safety and immunogenicity of a quadrivalent inactivated influenza vaccine compared to licensed trivalent inactivated influenza vaccines in adults D. P. Greenberg, C. A. Robertson, M. J. Noss, M. M. Blatter, R. Biedenbender, M. D. Decker 2013
Safety of a quadrivalent meningococcal serogroups A, C, W and Y conjugate vaccine (MenACWY-CRM) administered with routine infant vaccinations: results of an open-label, randomized, phase 3b controlled study in healthy infants Arturo Abdelnour, Peter E. Silas, Marta Raquel Valdes Lamas, Carlos Fernando Grazioso Aragon, Nan-Chang Chiu, Cheng-Hsun Chiu, Teobaldo Herrera Acuna, Tirza De Leon Castrejon, Allen Izu, Tatjana Odrljin, Igor Smolenov, Matthew Hohenboken, Peter M. Dull 2014
Safety and immunogenicity of typhoid fever and yellow fever vaccines when administered concomitantly with quadrivalent meningococcal ACWY glycoconjugate vaccine in healthy adults Martin Alberer, Gerd Burchard, Tomas Jelinek, Emil Reisinger, Jiri Beran, Lucie Cerna Hlavata, Eduardo Forleo-Neto, Alemnew F. Dagnew, Ashwani K. Arora 2015
Immunogenicity and safety of concomitant administration of a combined hepatitis A/B vaccine and a quadrivalent meningococcal conjugate vaccine in healthy adults Martin Alberer, Gerd Burchard, Tomas Jelinek, Emil C. Reisinger, Seetha Meyer, Eduardo Forleo-Neto, Alemnew F. Dagnew, Ashwani Kumar Arora 2015
Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine in healthy infants and toddlers given with routine vaccines in India Yeshwant K. Amdekar, Sanjay K. Lalwani, Ashish Bavdekar, S. Balasubramanian, Jugesh Chhatwal, Swarna Rekha Bhat, Valsan Philip Verghese, Susan P. Tansey, Durga Gadgil, Qin Jiang, Michael Pride, Emilio A. Emini, William C. Gruber, Daniel A. Scott 2013
Kawasaki disease and 13-valent pneumococcal conjugate vaccination among young children: A self-controlled risk interval and cohort study with null results Meghan A. Baker, Bethany Baer, Martin Kulldorff, Lauren Zichittella, Rebecca Reindel, Sandra DeLuccia, Hana Lipowicz, Katherine Freitas, Robert Jin, W. Katherine Yih 2019
Immunogenicity and safety of a cell culture-based quadrivalent influenza vaccine in adults: A Phase III, double-blind, multicenter, randomized, non-inferiority study Stephan Bart, Kevin Cannon, Darrell Herrington, Richard Mills, Eduardo Forleo-Neto, Kelly Lindert, Ahmed Abdul Mateen 2016
Safety of quadrivalent live attenuated influenza vaccine in subjects aged 2-49years Roger Baxter, Abigail Eaton, John Hansen, Laurie Aukes, Herve Caspard, Christopher S. Ambrose 2017
Prenatal Tetanus, Diphtheria, Acellular Pertussis Vaccination and Autism Spectrum Disorder Tracy A. Becerra-Culqui, Darios Getahun, Vicki Chiu, Lina S. Sy, Hung Fu Tseng 2018
Maternal and infant outcomes among women vaccinated against pertussis during pregnancy Abbey B. Berenson, Jacqueline M. Hirth, Mahbubur Rahman, Tabassum H. Laz, Richard E. Rupp, Kwabena O. Sarpong 2016
Lot-to-lot Consistency, Safety, Tolerability and Immunogenicity of an Investigational Hexavalent Vaccine in US Infants Stanley L. Block, Nicola P. Klein, Kwabena Sarpong, Stephen Russell, John Fling, Maria Petrecz, Sheryl Flores, Jin Xu, Guanghan Liu, Jon E. Stek, Ginamarie Foglia, Andrew W. Lee 2017
Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults Marc J. M. Bonten, Susanne M. Huijts, Marieke Bolkenbaas, Chris Webber, Scott Patterson, Samantha Gault, Cornelis H. van Werkhoven, Anna M. M. van Deursen, Elisabeth A. M. Sanders, Theo J. M. Verheij, Michael Patton, Anne McDonough, Anita Moradoghli-Haftvani, Helen Smith, Tracey Mellelieu, Michael W. Pride, Graham Crowther, Beate Schmoele-Thoma, Daniel A. Scott, Kathrin U. Jansen, Rita Lobatto, Bas Oosterman, Nils Visser, Esther Caspers, Andre Smorenburg, Emilio A. Emini, William C. Gruber, Diederick E. Grobbee 2015
Clinical Tolerance of In-Neonatal Intensive Care Unit Administration of Rotavirus Vaccine Courtney Briggs-Steinberg, David Aboudi, Gabrielle Hodson, Shetal Shah 2019
Intussusception risk and disease prevention associated with rotavirus vaccines in Australia's National Immunization Program John B. Carlin, Kristine K. Macartney, Katherine J. Lee, Helen E. Quinn, Jim Buttery, Ruth Lopert, Julie Bines, Peter B. McIntyre 2013
Evaluation of the safety of live attenuated influenza vaccine (LAIV) in children and adolescents with asthma and high-risk conditions: a population-based prospective cohort study conducted in England with the Clinical Practice Research Datalink Herve Caspard, Amy Steffey, Raburn M. Mallory, Christopher S. Ambrose 2018
Safety and immunogenicity of high-dose quadrivalent influenza vaccine in adults >=65years of age: A phase 3 randomized clinical trial Lee-Jah Chang, Ya Meng, Helene Janosczyk, Victoria Landolfi, H. Keipp Talbot, Q. H. D. Study Group 2019
Safety and immunogenicity of an AS01-adjuvanted varicella-zoster virus subunit candidate vaccine against herpes zoster in adults >=50 years of age Roman Chlibek, Jose M. Bayas, Harry Collins, Maria Luisa Rodriguez de la Pinta, Edouard Ledent, Johann F. Mols, Thomas C. Heineman 2013
Trends in Hospitalizations for Intussusception in California in Relationship to the Introduction of New Rotavirus Vaccines, 1985-2010 Despina G. Contopoulos-Ioannidis, Meira S. Halpern, Yvonne Maldonado 2015
Comparative Immunogenicity of Several Enhanced Influenza Vaccine Options for Older Adults: A Randomized, Controlled Trial Benjamin J. Cowling, Ranawaka A. P. M. Perera, Sophie A. Valkenburg, Nancy H. L. Leung, A. Danielle Iuliano, Yat Hung Tam, Jennifer H. F. Wong, Vicky J. Fang, Athena P. Y. Li, Hau Chi So, Dennis K. M. Ip, Eduardo Azziz-Baumgartner, Alicia M. Fry, Min Z. Levine, Shivaprakash Gangappa, Suryaprakash Sambhara, Ian G. Barr, Danuta M. Skowronski, J. S. Malik Peiris, Mark G. Thompson 2019
Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older Anthony L. Cunningham, Himal Lal, Martina Kovac, Roman Chlibek, Shinn-Jang Hwang, Javier Diez-Domingo, Olivier Godeaux, Myron J. Levin, Janet E. McElhaney, Joan Puig-Barbera, Carline Vanden Abeele, Timo Vesikari, Daisuke Watanabe, Toufik Zahaf, Anitta Ahonen, Eugene Athan, Jose F. Barba-Gomez, Laura Campora, Ferdinandus de Looze, H. Jackson Downey, Wayne Ghesquiere, Iris Gorfinkel, Tiina Korhonen, Edward Leung, Shelly A. McNeil, Lidia Oostvogels, Lars Rombo, Jan Smetana, Lily Weckx, Wilfred Yeo, Thomas C. Heineman, Z. O. E. Study Group 2016
Immunogenicity and safety of one or two doses of the quadrivalent meningococcal vaccine MenACWY-TT given alone or with the 13-valent pneumococcal conjugate vaccine in toddlers: A phase III, open-label, randomised study Clare L. Cutland, Terry Nolan, Scott A. Halperin, Zafer Kurugol, Khatija Ahmed, Kirsten P. Perrett, Peter Richmond, Helen S. Marshall, Mehmet Ceyhan, Devayani Kolhe, Marjan Hezareh, Marie Van Der Wielen 2018
Comparative immunogenicity and efficacy of 13-valent and 7-valent pneumococcal conjugate vaccines in reducing nasopharyngeal colonization: a randomized double-blind trial Ron Dagan, Scott Patterson, Christine Juergens, David Greenberg, Noga Givon-Lavi, Nurith Porat, Alejandra Gurtman, William C. Gruber, Daniel A. Scott 2013
Safety of diphtheria, tetanus, acellular pertussis and inactivated poliovirus (DTaP-IPV) vaccine Matthew F. Daley, W. Katherine Yih, Jason M. Glanz, Simon J. Hambidge, Komal J. Narwaney, Ruihua Yin, Lingling Li, Jennifer C. Nelson, James D. Nordin, Nicola P. Klein, Steven J. Jacobsen, Eric Weintraub 2014
Immunogenicity and safety of a combined measles, mumps, rubella and varicella live vaccine (ProQuad ) administered concomitantly with a booster dose of a hexavalent vaccine in 12-23-month-old infants Klaus A. Deichmann, Giuseppe Ferrera, Clement Tran, Stephane Thomas, Cecile Eymin, Martine Baudin 2015
Maternal Tdap vaccination and risk of infant morbidity Malini DeSilva, Gabriela Vazquez-Benitez, James D. Nordin, Heather S. Lipkind, Nicola P. Klein, T. Craig Cheetham, Allison L. Naleway, Simon J. Hambidge, Grace M. Lee, Michael L. Jackson, Natalie L. McCarthy, Elyse O. Kharbanda 2017
Evaluation of safety and immunogenicity of a live attenuated tetravalent (G1-G4) Bovine-Human Reassortant Rotavirus vaccine (BRV-TV) in healthy Indian adults and infants M. S. Dhingra, R. Kundu, M. Gupta, S. Kanungo, N. Ganguly, M. P. Singh, M. K. Bhattacharya, R. Ghosh, R. Kumar, D. Sur, S. M. Chadha, T. Saluja 2014
Efficacy of Recombinant Influenza Vaccine in Adults 50 Years of Age or Older Lisa M. Dunkle, Ruvim Izikson, Peter Patriarca, Karen L. Goldenthal, Derek Muse, Janice Callahan, Manon M. J. Cox, P. S. C. Study Team 2017
Randomized Comparison of Immunogenicity and Safety of Quadrivalent Recombinant Versus Inactivated Influenza Vaccine in Healthy Adults 18-49 Years of Age Lisa M. Dunkle, Ruvim Izikson, Peter A. Patriarca, Karen L. Goldenthal, Derek Muse, Manon M. J. Cox 2017
Immunogenicity and safety of MF59-adjuvanted quadrivalent influenza vaccine versus standard and alternate B strain MF59-adjuvanted trivalent influenza vaccines in older adults Brandon Essink, Carlos Fierro, Jeffrey Rosen, Amparo L. Figueroa, Bin Zhang, Carole Verhoeven, Jonathan Edelman, Igor Smolenov 2020
Hospital-based surveillance of intussusception among infants Eder Gatti Fernandes, Eyal Leshem, Manish Patel, Brendan Flannery, Alessandra Cristina Guedes Pellini, Maria Amelia Veras, Helena Keico Sato 2016
Pneumococcal polysaccharide vaccination in adults undergoing immunosuppressive treatment for inflammatory diseases--a longitudinal study Lara Fischer, Patricia Francis Gerstel, Antoine Poncet, Claire-Anne Siegrist, Emmanuel Laffitte, Cem Gabay, Joerg Dieter Seebach, Camillo Ribi 2015
Comparison of the safety and immunogenicity of an MF59-adjuvanted with a non-adjuvanted seasonal influenza vaccine in elderly subjects Sharon E. Frey, Mari Rose Aplasca-De Los Reyes, Humberto Reynales, Nancy Nazaire Bermal, Uwe Nicolay, Vas Narasimhan, Eduardo Forleo-Neto, Ashwani Kumar Arora 2014
Safety and immunogenicity of a 9-valent HPV vaccine in females 12-26 years of age who previously received the quadrivalent HPV vaccine Suzanne M. Garland, Tak-Hong Cheung, Shelly McNeill, Lone Kjeld Petersen, Josefina Romaguera, Jorge Vazquez-Narvaez, Oliver Bautista, Christine Shields, Scott Vuocolo, Alain Luxembourg 2015
Immunogenicity and safety of a mixed vaccination schedule with one dose of nonavalent and one dose of bivalent HPV vaccine versus two doses of nonavalent vaccine - A randomized clinical trial Vladimir Gilca, Chantal Sauvageau, Gitika Panicker, Gaston De Serres, Manale Ouakki, Elizabeth R. Unger 2018
Safety and immunogenicity of an inactivated quadrivalent influenza vaccine in children 6 months through 8 years of age David P. Greenberg, Corwin A. Robertson, Victoria A. Landolfi, Amitabha Bhaumik, Shelly D. Senders, Michael D. Decker 2014
Safety and immunogenicity of a quadrivalent influenza vaccine in adults 65 y of age and older David P. Greenberg, Corwin A. Robertson, H. Keipp Talbot, Michael D. Decker 2017
Sequential administration of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine-naive adults 60-64 years of age Richard N. Greenberg, Alejandra Gurtman, Robert W. Frenck, Cynthia Strout, Kathrin U. Jansen, James Trammel, Daniel A. Scott, Emilio A. Emini, William C. Gruber, Beate Schmoele-Thoma 2014
Pertussis Immunisation in Pregnancy Safety (PIPS) Study: A retrospective cohort study of safety outcomes in pregnant women vaccinated with Tdap vaccine Jennifer B. Griffin, Lennex Yu, Donna Watson, Nikki Turner, Tony Walls, Anna S. Howe, Yannan Jiang, Helen Petousis-Harris 2018
Evaluation of intussusception after oral monovalent rotavirus vaccination in South Africa Michelle J. Groome, Jacqueline E. Tate, Marion Arnold, Milind Chitnis, Sharon Cox, Corne de Vos, Mari Kirsten, Susanna M. le Grange, Jerome Loveland, Sello Machaea, Ashwini Maharaj, Nick Andrews, Shabir A. Madhi, Umesh D. Parashar 2019
Randomized Controlled Trial of the Safety and Immunogenicity of Revaccination With Tetanus-Diphtheria-Acellular Pertussis Vaccine (Tdap) in Adults 10 Years After a Previous Dose Scott A. Halperin, Catherine Donovan, Gary S. Marshall, Vitali Pool, Michael D. Decker, David R. Johnson, David P. Greenberg, Investigators Tdap Booster 2019
A Randomized Controlled Trial of the Safety and Immunogenicity of Tetanus, Diphtheria, and Acellular Pertussis Vaccine Immunization During Pregnancy and Subsequent Infant Immune Response Scott A. Halperin, Joanne M. Langley, Lingyun Ye, Donna MacKinnon-Cameron, May Elsherif, Victoria M. Allen, Bruce Smith, Beth A. Halperin, Shelly A. McNeil, Otto G. Vanderkooi, Shannon Dwinnell, R. Douglas Wilson, Bruce Tapiero, Marc Boucher, Nicole Le Saux, Andree Gruslin, Wendy Vaudry, Sue Chandra, Simon Dobson, Deborah Money 2018
Safety of DTaP-IPV/Hib vaccine administered routinely to infants and toddlers John Hansen, Julius Timbol, Ned Lewis, Vitali Pool, Michael D. Decker, David P. Greenberg, Nicola P. Klein 2016
Post-licensure safety surveillance study of routine use of quadrivalent meningococcal diphtheria toxoid conjugate vaccine (MenACWY-D) in infants and children J. Hansen, L. Zhang, A. Eaton, R. Baxter, C. A. Robertson, M. D. Decker, D. P. Greenberg, E. Bassily, N. P. Klein 2018
Post-licensure safety surveillance study of routine use of quadrivalent meningococcal diphtheria toxoid conjugate vaccine J. Hansen, L. Zhang, N. P. Klein, C. A. Robertson, M. D. Decker, D. P. Greenberg, E. Bassily, R. Baxter 2017
Non-inferiority of mammalian cell-derived quadrivalent subunit influenza virus vaccines compared to trivalent subunit influenza virus vaccines in healthy children: a phase III randomized, multicenter, double-blind clinical trial Robyn Hartvickson, Marilou Cruz, John Ervin, Donald Brandon, Eduardo Forleo-Neto, Alemnew F. Dagnew, Richa Chandra, Kelly Lindert, Ahmed Abdul Mateen 2015
Assessing the risk of intussusception and rotavirus vaccine safety in Canada Steven Hawken, Robin Ducharme, Laura C. Rosella, Eric I. Benchimol, Joanne M. Langley, Kumanan Wilson, Natasha S. Crowcroft, Scott A. Halperin, Shalina Desai, Monika Naus, Carolyn J. Sanford, Salah M. Mahmud, Shelley L. Deeks 2017
Immunogenicity and safety of an investigational hepatitis B vaccine with a Toll-like receptor 9 agonist adjuvant (HBsAg-1018) compared to a licensed hepatitis B vaccine in healthy adults 40-70 years of age William L. Heyward, Michael Kyle, Joseph Blumenau, Matthew Davis, Keith Reisinger, Martin L. Kabongo, Sean Bennett, Robert S. Janssen, Hamid Namini, J. Tyler Martin 2013
Safety study of live, oral human rotavirus vaccine: A cohort study in United States health insurance plans Veena Hoffman, Remon Abu-Elyazeed, Cheryl Enger, Daina B. Esposito, Michael C. Doherty, Scott C. Quinlan, Kathleen Skerry, Crystal N. Holick, Peter Basile, Leonard R. Friedland, Nicolas Praet, Stephanie Wery, Corinne Willame, David D. Dore, Dominique Rosillon 2018
Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16-26 years: a randomised, double-blind trial Warner K. Huh, Elmar A. Joura, Anna R. Giuliano, Ole-Erik Iversen, Rosires Pereira de Andrade, Kevin A. Ault, Deborah Bartholomew, Ramon M. Cestero, Edison N. Fedrizzi, Angelica L. Hirschberg, Marie-Helene Mayrand, Angela Maria Ruiz-Sternberg, Jack T. Stapleton, Dorothy J. Wiley, Alex Ferenczy, Robert Kurman, Brigitte M. Ronnett, Mark H. Stoler, Jack Cuzick, Suzanne M. Garland, Susanne K. Kjaer, Oliver M. Bautista, Richard Haupt, Erin Moeller, Michael Ritter, Christine C. Roberts, Christine Shields, Alain Luxembourg 2017
Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study Anders Hviid, Jorgen Vinslov Hansen, Morten Frisch, Mads Melbye 2019
Efficacy and safety of pentavalent rotavirus vaccine in Japan: a randomized, double-blind, placebo-controlled, multicenter trial Satoshi Iwata, Shuji Nakata, Susumu Ukae, Yoshitugu Koizumi, Yasuyuki Morita, Haruo Kuroki, Yoshiyuki Tanaka, Toshiyuki Shizuya, Florian Schodel, Michelle L. Brown, Jody Lawrence 2013
Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine compared to a 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine-naive adults Lisa A. Jackson, Alejandra Gurtman, Martin van Cleeff, Kathrin U. Jansen, Deepthi Jayawardene, Carmel Devlin, Daniel A. Scott, Emilio A. Emini, William C. Gruber, Beate Schmoele-Thoma 2013
Autism occurrence by MMR vaccine status among US children with older siblings with and without autism Anjali Jain, Jaclyn Marshall, Ami Buikema, Tim Bancroft, Jonathan P. Kelly, Craig J. Newschaffer 2015
Safety and immunogenicity of 13-valent pneumococcal conjugate vaccine formulations with and without aluminum phosphate and comparison of the formulation of choice with 23-valent pneumococcal polysaccharide vaccine in elderly adults: a randomized open-label trial Christine Juergens, Pierre J. T. de Villiers, Keymanthri Moodley, Deepthi Jayawardene, Kathrin U. Jansen, Daniel A. Scott, Emilio A. Emini, William C. Gruber, Beate Schmoele-Thoma 2014
Immunosuppressive drugs impairs antibody response of the polysaccharide and conjugated pneumococcal vaccines in patients with Crohn's disease Bjorn Kantso, Sofie Ingdam Halkjaer, Ole Ostergaard Thomsen, Erika Belard, Ida Benedikte Gottschalck, Charlotte Svaerke Jorgensen, Karen A. Krogfelt, Hans-Christian Slotved, Helene Ingels, Andreas Munk Petersen 2015
Maternal Tdap vaccination: Coverage and acute safety outcomes in the vaccine safety datalink, 2007-2013 Elyse Olshen Kharbanda, Gabriela Vazquez-Benitez, Heather S. Lipkind, Nicola P. Klein, T. Craig Cheetham, Allison L. Naleway, Grace M. Lee, Simon Hambidge, Michael L. Jackson, Saad B. Omer, Natalie McCarthy, James D. Nordin 2016
Immunogenicity, reactogenicity and safety of an inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine: a phase III, randomized trial in adults aged >=18 years Dorothee Kieninger, Eric Sheldon, Wen-Yuan Lin, Chong-Jen Yu, Jose M. Bayas, Julian J. Gabor, Meral Esen, Jose Luis Fernandez Roure, Silvia Narejos Perez, Carmen Alvarez Sanchez, Yang Feng, Carine Claeys, Mathieu Peeters, Bruce L. Innis, Varsha Jain 2013
Safety of measles-containing vaccines in 1-year-old children Nicola P. Klein, Edwin Lewis, Bruce Fireman, Simon J. Hambidge, Allison Naleway, Jennifer C. Nelson, Edward A. Belongia, W. Katherine Yih, James D. Nordin, Rulin C. Hechter, Eric Weintraub, Roger Baxter
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Rotavirus vaccination and short-term risk of adverse events in US infants J. Bradley Layton, Anne M. Butler, Catherine A. Panozzo, M. Alan Brookhart 2018
Immunogenicity and safety of a multicomponent meningococcal serogroup B vaccine in healthy adolescents in Korea--A randomised trial Hoan Jong Lee, Young June Choe, Young-Jin Hong, Kyung-Hyo Kim, Su Eun Park, Yun-Kyung Kim, Chi-Eun Oh, Hyunju Lee, Hyoyoung Song, Hans Bock, Daniela Casula, Chiranjiwi Bhusal, Ashwani Kumar Arora 2016
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Immunogenicity and Safety of the 13-Valent Pneumococcal Conjugate Vaccine versus the 23-Valent Polysaccharide Vaccine in Unvaccinated HIV-Infected Adults: A Pilot, Prospective Controlled Study Francesca Lombardi, Simone Belmonti, Massimiliano Fabbiani, Matteo Morandi, Barbara Rossetti, Giacinta Tordini, Roberto Cauda, Andrea De Luca, Simona Di Giambenedetto, Francesca Montagnani 2016
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Efficacy and safety of a pentavalent live human-bovine reassortant rotavirus vaccine (RV5) in healthy Chinese infants: A randomized, double-blind, placebo-controlled trial Zhaojun Mo, Yi Mo, Mingqiang Li, Junhui Tao, Xu Yang, Jilian Kong, Dingkai Wei, Botao Fu, Xueyan Liao, Jianli Chu, Yuanzheng Qiu, Darcy A. Hille, Micki Nelson, Susan S. Kaplan 2017
Pregnancy outcomes after antepartum tetanus, diphtheria, and acellular pertussis vaccination Jamie L. Morgan, Sangameshwar R. Baggari, Donald D. McIntire, Jeanne S. Sheffield 2015
Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial Flor M. Munoz, Nanette H. Bond, Maurizio Maccato, Phillip Pinell, Hunter A. Hammill, Geeta K. Swamy, Emmanuel B. Walter, Lisa A. Jackson, Janet A. Englund, Morven S. Edwards, C. Mary Healy, Carey R. Petrie, Jennifer Ferreira, Johannes B. Goll, Carol J. Baker 2014
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Impact of rotavirus vaccination on childhood hospitalizations for seizures: Heterologous or unforeseen direct vaccine effects? A. Salas, J. Pardo-Seco, M. Cebey-Lopez, J. M. Martinon-Martinez, J. Gomez-Rial, M. J. Curras-Tuala, S. Pischedda, R. Barral-Arca, A. Justicia-Grande, I. Rivero-Calle, J. Vilar, F. Martinon-Torres 2019
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Risk of fever after pediatric trivalent inactivated influenza vaccine and 13-valent pneumococcal conjugate vaccine Melissa S. Stockwell, Karen Broder, Philip LaRussa, Paige Lewis, Nadira Fernandez, Devindra Sharma, Angela Barrett, Jose Sosa, Claudia Vellozzi 2014
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Pneumococcal conjugate vaccine triggers a better immune response than pneumococcal polysaccharide vaccine in patients with chronic lymphocytic leukemia A randomized study by the Swedish CLL group Tobias Svensson, Magdalena Kattstrom, Ylva Hammarlund, Daniel Roth, P. O. Andersson, Magnus Svensson, Ingmar Nilsson, Lars Rombo, Honar Cherif, Eva Kimby 2018
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Coadministration of 13-valent pneumococcal conjugate and quadrivalent inactivated influenza vaccines in adults previously immunized with polysaccharide pneumococcal vaccine 23: a randomized clinical trial Allison R. Thompson, Nicola P. Klein, H. Jackson Downey, Scott Patterson, Vani Sundaraiyer, Wendy Watson, Keri Clarke, Kathrin U. Jansen, Shite Sebastian, William C. Gruber, Daniel A. Scott, Beate Schmoele-Thoma 2019
Asthma and allergy in children with and without prior measles, mumps, and rubella vaccination Clara Amalie Gade Timmermann, Christa Elyse Osuna, Ulrike Steuerwald, Pal Weihe, Lars K. Poulsen, Philippe Grandjean 2015
Immunogenicity, reactogenicity, and safety of inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine in healthy adults aged >=18 years: a phase III, randomized trial Juan Carlos Tinoco, Noris Pavia-Ruz, Aurelio Cruz-Valdez, Carlos Aranza Doniz, Vijayalakshmi Chandrasekaran, Walthere Dewe, Aixue Liu, Bruce L. Innis, Varsha K. Jain 2014
Immunogenicity and Safety of a 13-Valent Pneumococcal Conjugate Vaccine Given With DTaP Vaccine in Healthy Infants in Japan Takehiro Togashi, Kenji Okada, Masako Yamaji, Allison Thompson, Alejandra Gurtman, Mark Cutler, Masakazu Aizawa, William C. Gruber, Daniel A. Scott 2015
Immunogenicity and safety of a quadrivalent inactivated influenza vaccine compared with two trivalent inactivated influenza vaccines containing alternate B strains in adults: A phase 3, randomized noninferiority study John T. Treanor, Frank R. Albano, Daphne C. Sawlwin, Alison Graves Jones, Jolanta Airey, Neil Formica, Vince Matassa, Jane Leong 2017
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Pneumococcal Conjugate Vaccine Safety in Elderly Adults Hung Fu Tseng, Lina S. Sy, Lei Qian, In-Lu A. Liu, Cheryl Mercado, Bruno Lewin, Sara Y. Tartof, Jennifer Nelson, Lisa A. Jackson, Matthew F. Daley, Eric Weintraub, Nicola P. Klein, Edward Belongia, Elizabeth G. Liles, Steven J. Jacobsen 2018
Safety of Quadrivalent Meningococcal Conjugate Vaccine in 11- to 21-Year-Olds Hung-Fu Tseng, Lina S. Sy, Bradley K. Ackerson, Rulin C. Hechter, Sara Y. Tartof, Mendel Haag, Jeffrey M. Slezak, Yi Luo, Christine A. Fischetti, Harp S. Takhar, Yan Miao, Marianne Cunnington, Zendi Solano, Steven J. Jacobsen 2017
Impact of rotavirus vaccination in Germany: rotavirus surveillance, hospitalization, side effects and comparison of vaccines Ulrike Uhlig, Karel Kostev, Volker Schuster, Sibylle Koletzko, Holm H. Uhlig
Rotavirus Vaccination and the Risk of Celiac Disease or Type 1 Diabetes in Finnish Children at Early Life Outi Vaarala, Jukka Jokinen, Mika Lahdenkari, Tuija Leino 2017
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Immunogenicity and safety of the 13-valent Pneumococcal Conjugate vaccine in 23-valent pneumococcal polysaccharide vaccine-naive and pre-immunized patients under treatment with chronic haemodialysis: a longitudinal quasi-experimental phase IV study S. J. Vandecasteele, D. De Bacquer, R. Caluwe, S. Ombelet, B. Van Vlem 2018
A Randomized, Double-Blind, Phase III Study of the Immunogenicity and Safety of a 9-Valent Human Papillomavirus L1 Virus-Like Particle Vaccine (V503) Versus Gardasil in 9-15-Year-Old Girls Timo Vesikari, Nicholas Brodszki, Pierre van Damme, Javier Diez-Domingo, Giancarlo Icardi, Lone Kjeld Petersen, Clement Tran, Stephane Thomas, Alain Luxembourg, Martine Baudin 2015
Immunogenicity, Safety, and Tolerability of Bivalent rLP2086 Meningococcal Group B Vaccine Administered Concomitantly With Diphtheria, Tetanus, and Acellular Pertussis and Inactivated Poliomyelitis Vaccines to Healthy Adolescents Timo Vesikari, Jacek Wysocki, Johannes Beeslaar, Joseph Eiden, Qin Jiang, Kathrin U. Jansen, Thomas R. Jones, Shannon L. Harris, Robert E. O'Neill, Laura J. York, John L. Perez 2016
Safety of MF59-adjuvanted influenza vaccination in the elderly: results of a comparative study of MF59-adjuvanted vaccine versus nonadjuvanted influenza vaccine in northern Italy Marco Villa, Steven Black, Nicola Groth, Kenneth J. Rothman, Giovanni Apolone, Noel S. Weiss, Ivana Aquino, Liana Boldori, Fausta Caramaschi, Antonio Gattinoni, Giancarlo Malchiodi, Antonio Crucitti, Giovanni Della Cioppa, Elio Scarpini, Domenico Mavilio, Salvatore Mannino 2013
Immunogenicity and Safety of an Inactivated Quadrivalent Influenza Vaccine in US Children 6-35 Months of Age During 2013-2014: Results From A Phase II Randomized Trial Long Wang, Vijayalakshmi Chandrasekaran, Joseph B. Domachowske, Ping Li, Bruce L. Innis, Varsha K. Jain 2016
Intussusception risk after rotavirus vaccination in U.S. infants W. Katherine Yih, Tracy A. Lieu, Martin Kulldorff, David Martin, Cheryl N. McMahill-Walraven, Richard Platt, Nandini Selvam, Mano Selvan, Grace M. Lee, Michael Nguyen 2014
Fever after influenza, diphtheria-tetanus-acellular pertussis, and pneumococcal vaccinations E. B. Walter, N. P. Klein, A. P. Wodi, W. Rountree, C. A. Todd, A. Wiesner, J. Duffy, P. L. Marquez, K. R. Broder 2020
Safety of tetanus, diphtheria, and acellular pertussis vaccination among pregnant active duty U.S. military women C. Hall, L. M. Abramovitz, A. T. Bukowinski, A. A. Ricker, Z. G. Khodr, G. R. Gumbs, N. Y. Wells, A. M. S. Conlin 2020
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Association between Rotavirus Vaccination and Type 1 Diabetes in Children J. M. Glanz, C. L. Clarke, S. Xu, M. F. Daley, J. A. Shoup, E. B. Schroeder, B. J. Lewin, D. L. McClure, E. Kharbanda, N. P. Klein, F. Destefano 2020
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A case-control study of risk factors for intussusception among infants in eastern France after the introduction of the rotavirus vaccine A. Fotso Kamdem, C. Vidal, L. Pazart, F. Leroux, A. Pugin, C. Savet, G. Sainte-Claire Deville, D. Guillemot, J. Massol 2019
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Survey of rotavirus-associated severe complications in Aichi Prefecture F. Hattori, Y. Kawamura, J. I. Kawada, S. Kojima, J. Natsume, K. Ito, S. Saito, Y. Kitagawa, A. Okumura, T. Yoshikawa 2018
Comparison of immunogenicity and safety of an influenza vaccine administered concomitantly with a 13-valent pneumococcal conjugate vaccine or 23-valent polysaccharide pneumococcal vaccine in the elderly Y. B. Seo, W. S. Choi, J. Lee, J. Y. Song, H. J. Cheong, W. J. Kim 2017
The risk of intussusception following monovalent rotavirus vaccination in England: A self-controlled case-series evaluation J. Stowe, N. Andrews, S. Ladhani, E. Miller 2016
Concomitant use of VAQTA with PedvaxHIB and Infanrix in 12 to 17 month old children M. Petrecz, K. P. Ramsey, J. E. Stek, J. C. Martin, S. O. Klopfer, B. Kuter, F. P. Schdel, A. W. Lee 2016
Preventing pertussis in the early infant: Development and results of a prenatal vaccination program J. Acosta, C. Benages, M. A. Daz, M. Xiberta, F. Muiz 2016
The impact of hepatitis B vaccination status on the risk of diabetes, implicating diabetes risk reduction by successful vaccination J. Huang, H. Y. Ou, J. Lin, R. Karnchanasorn, W. Feng, R. Samoa, L. M. Chuang, K. C. Chiu 2015
Immunogenicity and safety of concomitant MF59-adjuvanted influenza vaccine and 23-valent pneumococcal polysaccharide vaccine administration in older adults J. Y. Song, H. J. Cheong, T. F. Tsai, H. A. Chang, M. J. Choi, J. H. Jeon, S. H. Kang, E. J. Jeong, J. Y. Noh, W. J. Kim 2015b
Postlicensure surveillance for pre-specified adverse events following the 13-valent pneumococcal conjugate vaccine in children H. F. Tseng, L. S. Sy, I. L. A. Liu, L. Qian, S. M. Marcy, E. Weintraub, K. Yih, R. Baxter, J. M. Glanz, J. Donahue, A. Naleway, J. Nordin, S. J. Jacobsen 2013
Participant-Centered Online Active Surveillance for Adverse Events Following Vaccination in a Large Clinical Trial: Feasibility and Usability Study S. A. Munnoch, P. Cashman, R. Peel, J. Attia, A. Hure, D. N. Durrheim 2019
Lower Incidence Rate of Type 1 Diabetes after Receipt of the Rotavirus Vaccine in the United States, 20012017 M. A. M. Rogers, T. Basu, C. Kim 2019
Randomized clinical trial of the safety and immunogenicity of the Tdap vaccine in pregnant Mexican women J. Z. V. Perez, J. M. R. Aranda, M. de la O Cavazos, M. D. Z. Osuna, J. P. Davila, M. R. B. Elizondo, M. V. G. Meza, F. J. G. Elizondo, A. M. R. Gonzalez 2017
A Retrospective Cohort Study of Safety Outcomes in New Zealand Infants Exposed to Tdap Vaccine in Utero H. Petousis-Harris, Y. N. Jiang, L. Yu, D. Watson, T. Walls, N. Turner, A. S. Howe, J. B. Griffin 2019
Safety and Immunogenicity of Meningococcal ACWY Conjugate Versus Polysaccharide Vaccine in Children 2 to 10 Years of Age Euctr Outside EU/EEA,, Euctr Outside EU/EEA, 2014
Immunogenicity and safety of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT) in >/=56-year-olds: A Phase III randomized study Esteves-Jaramillo, A., Koehler, T., Jeanfreau, R., Neveu, D., Jordanov, E., Singh Dhingra, M. 2020
Immunogenicity and safety of the adjuvanted recombinant zoster vaccine co-administered with the 23-valent pneumococcal polysaccharide vaccine in adults 50years of age: a randomized trial C. Marchal, H. Lal, A. Poder, M. Ferguson, I. Enweonye, T. C. Heineman, C. Herv, P. Rheault, J. Talli, D. Wauters, et al. 2018
Febrile Seizure Risk After Vaccination in Children 6 to 23 Months Jonathan Duffy, Eric Weintraub, Simon J. Hambidge, Lisa A. Jackson, Elyse O. Kharbanda, Nicola P. Klein, Grace M. Lee, S. Michael Marcy, Cynthia C. Nakasato, Allison Naleway, Saad B. Omer, Claudia Vellozzi, Frank DeStefano 2016
Retrospective multicenter matched case-control study on the risk factors for intussusception in infants less than 1 year of age with a special focus on rotavirus vaccines - the German Intussusception Study Doris Oberle, Marcus Hoffelner, Jutta Pavel, Dirk Mentzer, Immanuel Barth, Ursula Drechsel-Bauerle, Brigitte Keller-Stanislawski 2020
The adjuvanted recombinant zoster vaccine co-administered with a tetanus, diphtheria and pertussis vaccine in adults aged >=50 years: A randomized trial Strezova, Ana, Lal, Himal, Enweonye, Igwebuike, Campora, Laura, Beukelaers, Pierre, Segall, Nathan, Heineman, Thomas C., Schuind, Anne E., Oostvogels, Lidia 2019
Safety and Immunogenicity Study of the Hepatitis B Vaccine, HEPLISAV, Compared to Engerix-B Vaccine Corporation Dynavax Technologies 2015
Safety and Immunogenicity of Fluzone Quadrivalent, Flublok Quadrivalent, and Fluzone High-Dose, Influenza Vaccines, 2018-2019 Formulations Sanofi Company Sanofi Pasteur,Sanofi 2018
Immunogenicity, safety and inter-lot consistency of a meningococcal conjugate vaccine (MenACYW-TT) in adolescents and adults: A Phase III randomized study Dhingra, M. S. Peterson, J. Hedrick, J. Pan, J. Neveu, D. Jordanov 2020
Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case-Control Study Leslie, D. L., Kobre, R. A., Richmand, B. J., Aktan Guloksuz, S., Leckman, J. F. 2017
Evaluating clinical effectiveness of 13-valent pneumococcal conjugate vaccination against pneumonia among middle-aged and older adults in Catalonia: results from the EPIVAC cohort study Vila-Corcoles, Angel, Ochoa-Gondar, Olga, e Diego, Cinta, Satue, Eva, Aragn, Mara, Vila-Rovira, Angel, Gomez-Bertomeu, Frederic, Magarolas, Ramon, Figuerola-Massana, Enric, Raga, Xavier, Perez, Mar O., Ballester, Frederic 2018
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Evaluation of Intussusception after Monovalent Rotavirus Vaccination in Africa Tate, J. E., Mwenda, J. M., Armah, G., Jani, B., Omore, R., Ademe, A., Mujuru, H., Mpabalwani, E., Ngwira, B., Cortese, M. M., Mihigo, R., Glover-Addy, H., Mbaga, M., Osawa, F., Tadesse, A., Mbuwayesango, B., Simwaka, J., Cunliffe, N., Lopman, B. A., Weldegebriel, G., Ansong, D., Msuya, D., Ogwel, B., Karengera, T., Manangazira, P., Bvulani, B., Yen, C., Zawaira, F. R., Narh, C. T., Mboma, L., Saula, P., Teshager, F., Getachew, H., Moeti, R. M., Eweronu-Laryea, C., Parashar, U. D. 2018
Intussusception and Monovalent Rotavirus Vaccination in Singapore: Self-Controlled Case Series and Risk-Benefit Study Yung, C. F., Chan, S. P., Soh, S., Tan, A., Thoon, K. C. 2015
Intussusception risk after RotaTeq vaccination: evaluation from worldwide spontaneous reporting data using a self-controlled case series approach Escolano, S., Hill, C., Tubert-Bitter, P. 2015
Immunogenicity and safety of a booster dose of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT) in adolescents and adults: a Phase III randomized study Anez, G., Hedrick, J., Simon, M. W., Christensen, S., Jeanfreau, R., Yau, E., Pan, J., Jordanov, E., Dhingra, M. S. 2020
Acute Demyelinating Events Following Vaccines: A Case-Centered Analysis Baxter, R., Lewis, E., Goddard, K., Fireman, B., Bakshi, N., DeStefano, F., Gee, J., Tseng, H. F., Naleway, A. L., Klein, N. P. 2016
Adverse Events After Routine Immunization of Extremely Low-Birth-Weight Infants DeMeo, S. D., Raman, S. R., Hornik, C. P., Wilson, C. C., Clark, R., Smith, P. B. 2015
Sudden-Onset Sensorineural Hearing Loss after Immunization: A Case-Centered Analysis Baxter, R., Lewis, N., Bohrer, P., Harrington, T., Aukes, L., Klein, N. P. 2016
A Phase II, randomized, immunogenicity and safety study of a quadrivalent meningococcal conjugate vaccine, MenACYW-TT, in healthy adolescents in the United States Chang, L. J., Hedrick, J., Christensen, S., Pan, J., Jordanov, E., Dhingra, M. S. 2020b
Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine and an MF59-adjuvanted influenza vaccine after concomitant vaccination in 60-year-old adults Song, Joon Young, Cheong, Hee Jin, Hyun, Hak Jun, Seo, Yu Bin, Lee, Jacob, Wie, Seong-Heon, Choi, Min Joo, Choi, Won Suk, Noh, Ji Yun, Yun, Jae Won, Yun, Jin Gu, Kim, Woo Joo 2017b
Safety and Efficacy of HEPLISAV Hepatitis B Virus Vaccine Compared With Engerix-B Vaccine Corporation, Dynavax Technologies 2006
Study Comparing a 13-valent Pneumococcal Conjugate Vaccine With 23-valent Pneumococcal Polysaccharide Vaccine in Adults Pfizer 2007
Safety and Immunogenicity of a Quadrivalent Meningococcal Conjugate Vaccine in Healthy Meningococcal-Nave Children 2-9 Years of Age: A Phase III, Randomized Study Baccarini, C. I., Simon, M. W., Brandon, D., Christensen, S., Jordanov, E., Dhingra, M. S. 2020
The Association of Prenatal Tetanus, Diphtheria, and Acellular Pertussis (Tdap) Vaccination With Attention-Deficit/Hyperactivity Disorder Becerra-Culqui, T. A., Getahun, D., Chiu, V., Sy, L. S., Tseng, H. F. 2020
A randomized, controlled trial comparing the immunogenecity and safety of a 23-valent pneumococcal polysaccharide vaccination to a repeated dose 13-valent pneumococcal conjugate vaccination in kidney transplant recipients Eriksson, M., Kyhty, H., Saha, H., Lahdenkari, M., Koskinen, P., Mkisalo, H., Anttila, V. J. 2020
A longitudinal cohort study of childhood MMR vaccination and seizure disorder among American children Geier, D. A., Geier, M. R. 2020
Active SMS-based surveillance of adverse events following immunisation with influenza and pertussis-containing vaccines in Australian pregnant women using AusVaxSafety Glover, C., Crawford, N., Leeb, A., Wood, N., Macartney, K. 2020
Immunogenicity and safety of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT) in adults 56 years of age and older: a Phase II randomized study Kirstein, J., Pina, M., Pan, J., Jordanov, E., Dhingra, M. S. 2020
A study to evaluate the immunogenicity and shedding of live attenuated influenza vaccine strains in children 24<48 months of age Mallory, R. M., Nyborg, A., Kalyani, R. N., Yuan, Y., Block, S. L., Dubovsky, F. 2020
Impact of rotavirus vaccination on intussusception hospital admissions in England McGeoch, L. J., Finn, A., Marlow, R. D. 2020
Impact of 23-valent pneumococcal polysaccharide vaccination on the frequency of pneumonia-related hospitalization and survival in elderly patients with prostate cancer: A seven-year nationwide matched cohort study Li, Chung-Yi, Chen, Liang-Cheng, Lin, Hon-Yi, Lee, Moon-Sing, Hung, Shih-Kai, Lai, Chun-Liang, Huang, Li-Wen, Yu, Ben-Hui, Hsu, Feng-Chun, Chiou, Wen-Yen 2020
Surveillance for Guillain-Barre syndrome after influenza vaccination among U.S. Medicare beneficiaries during the 2017-2018 season Perez-Vilar, Silvia, Wernecke, Michael, Arya, Deepa, Lo, An-Chi, Lufkin, Bradley, Hu, Mao, Chu, Steve, MaCurdy, Thomas E., Kelman, Jeffrey, Forshee, Richard A. 2019
Safety and Efficacy of Simultaneous Inoculations of Pneumococcal and Influenza Vaccines in Patients with Coronary Artery Disease Shimada, Kazunori, Morinaga, Hiroaki, Kiyanagi, Takashi, Miyazaki, Tetsuro, Nishitani-Yokoyama, Miho, Okai, Iwao, Tamura, Hiroshi, Konishi, Hakuoh, Kurata, Takeshi, Miyauchi, Katsumi, Daida, Hiroyuki 2020
Early exposure to the combined measles-mumps-rubella vaccine and thimerosal-containing vaccines and risk of autism spectrum disorder Uno, Y., Uchiyama, T., Kurosawa, M., Aleksic, B., Ozaki, N. 2015
Similar relative risks of seizures following measles containing vaccination in children born preterm compared to full-term without previous seizures or seizure-related disorders McClure, D. L., Jacobsen, S. J., Klein, N. P., Naleway, A. L., Kharbanda, E. O., Glanz, J. M., Jackson, L. A., Weintraub, E. S., McLean, H. Q. 2019
Does Rotavirus Vaccination Affect Longer-Term Intussusception Risk in US Infants? Burke, R. M., Tate, J. E., Dahl, R. M., Aliabadi, N., Parashar, U. D. 2020
The risk of febrile seizures following influenza and 13-valent pneumococcal conjugate vaccines Baker, M. A., Jankosky, C., Yih, W. K., Gruber, S., Li, L., Cocoros, N. M., Lipowicz, H., Coronel-Moreno, C., DeLuccia, S., Lin, N. D., McMahill-Walraven, C. N., Menschik, D., Selvan, M. S., Selvam, N., Chen Tilney, R., Zichittella, L., Lee, G. M., Kawai, A. T. 2020
Intussusception and Kawasaki disease after rotavirus vaccination in Taiwanese infants Huang, Wan-Ting, Juan, Yi-Chen, Liu, Chia-Hung, Yang, Yen-Yun, Chan, K. Arnold 2020
Methods for addressing "innocent bystanders" when evaluating safety of concomitant vaccines Wang, Shirley V., Abdurrob, Abdurrahman, Spoendlin, Julia, Lewis, Edwin, Newcomer, Sophia R., Fireman, Bruce, Daley, Matthew F., Glanz, Jason M., Duffy, Jonathan, Weintraub, Eric S., Kulldorff, Martin
Kawasaki Disease following administration of 13-valent pneumococcal conjugate vaccine in young children Yung, Chee Fu, Ma, Xiangmei, Cheung, Yin Bun, Oh, Bee Khiam, Soh, Sally, Thoon, Koh Cheng 2019
Influenza and pneumococcal vaccination and risk of stroke or transient ischaemic attack-matched case control study Siriwardena, A. N., Asghar, Z., Coupland, C. C. 2014
Pneumococcal pneumonia and the risk of stroke: a population-based follow-up study Chen, L. F., Chen, H. P., Huang, Y. S., Huang, K. Y., Chou, P., Lee, C. C. 2012
Associations between Pneumococcal Vaccination and Adverse Outcomes in Patients with Suspected Acute Coronary Syndrome Zahid, M., Singla, I., Good, C.B., l., et 2012

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