Diagnosis and Management of Infantile Hemangioma

Project Summary Title and Description

Diagnosis and Management of Infantile Hemangioma
To systematically review evidence addressing the diagnosis and management of infantile hemangiomas (IH).
Authors of Report
Methodology description
We included comparative studies of imaging and pharmacologic and surgical interventions published in English from 1982 to October 2014. We also included case series addressing harms of interventions and case series and systematic and narrative reviews to address contextual questions. Two investigators independently screened studies against predetermined inclusion criteria and independently rated study quality. We extracted data into evidence and summary tables and summarized them qualitatively and quantitatively via network meta-analysis. We also assessed the strength of the evidence for key interventions and outcomes.
PMID: 26889533; AHRQ: http://effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productid=2170 Data has been retrospectively entered. Study characteristics and outcomes data have been uploaded to SRDR. See files "IH_Outcomes and Quality for Harms Data" and "IH_Outcomes_Population Characteristics_Quality Data for Comparative Effectivenss".
Funding Source

Key Questions

1. KQ2: Among newborns, infants, and children up to 18 years of age with infantile hemangiomas who have been referred for pharmacologic intervention, what is the comparative effectiveness (benefits/harms) of corticosteroids or beta-blockers?
2. KQ4: Among newborns, infants, and children up to 18 years of age with infantile hemangiomas who have been referred for surgical intervention, what is the comparative effectiveness (benefits/ harms) of various types of surgical interventions (including laser and resection)?
3. Harms

Associated Extraction Forms

Associated Studies (each link opens a new tab)

Atenolol versus propranolol for the treatment of infantile hemangiomas: a randomized controlled study2014
Evaluation of topical steroids in the treatment of superficial hemangioma2010
Corticosteroids therapy in the management of infantile cutaneous hemangiomas2006
Oral versus high-dose pulse corticosteroids for problematic infantile hemangiomas: a randomized, controlled trial2007
Propranolol and infantile hemangiomas: different routes of administration, a randomized clinical trial2013
Propranolol vs prednisolone for symptomatic proliferating infantile hemangiomas: a randomized clinical trial2014
A randomized controlled trial of propranolol for infantile hemangiomas2011
RCT of timolol maleate gel for superficial infantile hemangiomas in 5- to 24-week-olds2013
A Randomized, Controlled Trial of Oral Propranolol in Infantile Hemangioma2015
Propranolol therapy for reducing the number of nasal infantile hemangioma invasive procedures2014
Propranolol for infantile hemangioma (PINCH): an open-label trial to assess the efficacy of propranolol for treating infantile hemangiomas and for determining the decline in heart rate to predict response to propranolol2013
Imiquimod 5% cream versus timolol 0.5% ophthalmic solution for treating superficial proliferating infantile haemangiomas: a retrospective study2013
Retrospective study of the treatment of infantile hemangiomas using a combination of propranolol and pulsed dye laser2013
Comparison of efficacy of intralesional bleomycin and oral propanolol in management of hemangiomas.2012
A controlled study of topical 0.25% timolol maleate gel for the treatment of cutaneous infantile capillary hemangiomas2012
Propranolol versus prednisone in the treatment of infantile hemangiomas: a retrospective comparative study
Propranolol vs corticosteroids for infantile hemangiomas: a multicenter retrospective analysis2011
Treatment of infantile haemangiomas with atenolol: comparison with a historical propranolol group.2011
Propranolol, a very promising treatment for ulceration in infantile hemangiomas: a study of 20 cases with matched historical controls
Management of cutaneous hemangiomas: a retrospective analysis of 1109 cases and comparison of conventional dose prednisolone with high-dose methylprednisolone therapy2001
Treatment of infantile haemangiomas with atenolol: comparison with a historical propranolol group.2012
Expanding the therapeutic repertoire of infantile haemangiomas: cohort-blinded study of oral nadolol compared with propranolol2012
Treatment of infantile hemangiomas with the 595-nm pulsed dye laser using different pulse widths in an Asian population2012
Capillary hemangioma (strawberry mark) of infancy: comparison of argon and Nd:YAG laser treatment1989
Retrospective clinical comparison of hemangioma treatment by flashlamp-pumped (585 nm) and frequency-doubled Nd:YAG (532 nm) lasers2001
Subglottic hemangioma: a comparison of CO2 laser, Neodym-Yag laser, and tracheostomy2005
Comparison study of a traditional pulsed dye laser versus a long-pulsed dye laser in the treatment of early childhood hemangiomas2006
Cryogen spray cooling and pulsed dye laser treatment of cutaneous hemangiomas2001
Randomised controlled study of early pulsed dye laser treatment of uncomplicated childhood haemangiomas: results of a 1-year analysis2002
Superficial hemangioma: pulsed dye laser versus wait-and-see2013
Complications of systemic corticosteroid therapy for problematic hemangioma1999
Intralesional corticosteroid therapy in proliferating head and neck hemangiomas: a review of 155 cases2000
Evaluating systemic prednisone therapy for proliferating haemangioma in infancy2008
Intralesional corticosteroid therapy in hemangiomas: clinical outcome in 160 cases2008
Treatment of hemangiomas of infants with high doses of prednisone1996
Local steroid therapy in cutaneous hemangiomas1996
Intralesional corticosteroid therapy for infantile hemangiomas1989
Oral prednisolone for infantile hemangioma: efficacy and safety using a standardized treatment protocol2011
Twenty years' experience of steroids in infantile hemangioma--a developing country's perspective2009
Normalisation of refractive error after steroid injection for adnexal haemangiomas1991
Corticosteroid therapy in the treatment of cutaneous hemangioma of infancy and childhood1983
The treatment of periorbital infantile hemangioma with intralesional corticosteroid1985
Evaluation of intra-lesional corticosteroids in the treatment of peri-ocular haemangioma of infancy: still an alternative besides propranolol.2012
Intralesional corticosteroid therapy for childhood cutaneous hemangiomas1994
Use of ultrasonic dissection in the early surgical management of periorbital haemangiomas2008
Treatment of hemangiomas in children using a Nd:YAG laser in conjunction with ice cooling of the epidermis: techniques and results2003
Haemostatic squeezing and purse-string sutures: optimising surgical techniques for early excision of critical infantile haemangiomas2007
Flashlamp-pumped pulsed dye laser for hemangiomas in infancy: treatment of superficial vs mixed hemangiomas2000
Surgical treatment of haemangioma in infants2005
Purse-string closure of hemangiomas: early results of a follow-up study2009
Propranolol as first-line treatment of head and neck hemangiomas.2011
Resection of amblyogenic periocular hemangiomas: indications and outcomes2010
Liquid nitrogen cryotherapy of lip mucosa hemangiomas under inhalation general anesthesia with sevoflurane in early infancy2009
Propranolol for severe infantile hemangiomas: follow-up report2009
Nasal tip haemangiomas: guidelines for an early surgical approach2010
Propranolol as first-line treatment for rapidly proliferating infantile haemangiomas2011
Use of flashlamp-pumped pulsed dye laser in the treatment of superficial vascular malformations and ulcerated hemangiomas2011
beta-blockers for infantile hemangiomas: a single-institution experience2011
Outcomes of childhood hemangiomas treated with the pulsed-dye laser with dynamic cooling: a retrospective chart analysis.2009
Treatment of infantile hemangioma with optimal pulse technology2010
Propranolol for treatment of ulcerated infantile hemangiomas2011
Guide to early surgical management of lip hemangiomas based on our experience of 214 cases2011
Topical propranolol therapy for infantile hemangiomas2012
Surgical treatment of infantile hemangioma in a multidisciplinary vascular anomalies clinic2011
Use of propranolol for treatment of infantile haemangiomas in an outpatient setting2012
Propranolol in the treatment of problematic infantile hemangioma: review of 35 consecutive patients from a vascular anomalies clinic.2012
Propranolol treatment of infantile hemangioma: clinical and radiologic evaluations2012
Effect of propranolol on the treatment of infantile hemangiomas: a single tertiary center 3-year experience
Cardiovascular and blood glucose parameters in infants during propranolol initiation for treatment of symptomatic infantile hemangiomas2013
Propranolol in a case series of 174 patients with complicated infantile haemangioma: indications, safety and future directions2013
The Nd:YAG laser treatment of hemangioma1994
Propranolol given orally for proliferating infantile haemangiomas: analysis of efficacy and serological changes in vascular endothelial growth factor and endothelial nitric oxide synthase in 35 patients.2013
Propranolol therapy of infantile hemangiomas: efficacy, adverse effects, and recurrence2013
Efficacy of pulse dye laser therapy for the treatment of ulcerated haemangiomas: a review of 78 patients2003
Treatment of ulcerated hemangiomas infancy1994
SMAS fold flap and ADM repair of the parotid bed following removal of parotid haemangiomas via pre- and retroauricular incisions to improve cosmetic outcome and prevent Frey's syndrome2008
Serial excision of facial hemangiomas2011
Initial experience with a multidisciplinary strategy for initiation of propranolol therapy for infantile hemangiomas2011
Effect of early long-pulse pulsed dye laser treatment in infantile hemangiomas2014
Oral propranolol: an effective, safe treatment for infantile hemangiomas2011
Propranolol therapy in 55 infants with infantile hemangioma: dosage, duration, adverse effects, and outcome2011
Propranolol for problematic head and neck hemangiomas: an analysis of 37 consecutive patients2012
Refractive and structural changes in infantile periocular capillary haemangioma treated with propranolol
Timolol maleate 0.5% or 0.1% gel-forming solution for infantile hemangiomas: a retrospective, multicenter, cohort study.2012
Propranolol as the first-line therapy for infantile hemangiomas: preliminary results of two centers2012
Topical timolol maleate for treatment of infantile haemangiomas: preliminary results of a prospective study2013
Topical propranolol for treatment of superficial infantile hemangiomas2012
Propranolol treatment for severe infantile hemangiomas: a single-centre 3-year experience2012
A retrospective study of propranolol therapy in 109 infants with infantile hemangioma2013
Preliminary experience on treatment of infantile hemangioma with low-dose propranolol in China2013
The use of propranolol for complicated infantile hemangiomas2013
Treatment of facial haemangiomas: the present status of surgery2001
Twenty-four-hour hospitalization for patients initiating systemic propranolol therapy for infantile hemangiomas--is it indicated?2013
Vascular lip enlargement: Part I. Hemangiomas--tenets of therapy1997
Adverse effects of propranolol treatment for infantile hemangiomas in China2014
Use of propranolol for the treatment infantile hemangiomas in the maxillofacial region2013
Oral propranolol therapy for infantile hemangiomas beyond the proliferation phase: a multicenter retrospective study2011
Efficacy and safety of propranolol as first-line treatment for infantile hemangiomas.2011
Propranolol in the management of infantile hemangiomas: clinical response and predictors2012
Oral propranolol for treating infantile hemangiomas: a case series of 57 patients2012
Successful discontinuation of propranolol for infantile hemangiomas of the head and neck at 12 months of age2013
Treatment of infantile hemangiomas with propranolol: clinical guidelines2014
Carbon dioxide laser in subglottic hemangioma. An update-- Not Found --
Evaluation of intralesional propranolol for periocular capillary hemangioma2011
Not Found - Please check PubMed ID for accuracy.
Long term follow-up of intralesional laser photocoagulation (ILP) for hemangioma patients2013
Long term follow-up of intralesional laser photocoagulation (ILP) for hemangioma patients
Double-blind randomized pilot trial evaluating the efficay of oral propranolol on infantile hemangiomas in infants < 4 months of age2013
Effects of propranolol vs perdnisolone vs propranolo with prednisolone in the management of infantile hemangioma: a randomized controlled study2013
Is cardiovascular evaluation necessary prior to and during beta-blocker therapy for infantile hemangiomas?2015
Propranolol in treatment of huge and complicated infantile hemangiomas in egyptian children2014
Treatment of Severe Infantile Hemangiomas With Propranolol: An Evaluation of the Efficacy and Effects of Cardiovascular Parameters in 25 Consecutive Patients2015
Propranolol for infantile haemangiomas: single centre experience of 250 cases and proposed therapeutic protocol2014
Management of problematic infantile hemangioma using intralesional triamcinolone: Efficacy and safety in 100 infants2014
Combination therapy of infantile hemangiomas with pulsed dye laser and Nd:YAG laser is effective and safe2014
Propranolol in infantile haemangioma: simplifying pretreatment monitoring2014
Efficacy and Safety of Propranolol for the Treatment of Infantile Hemangioma: A Presentation of Ninety-Nine Cases2014
Effectiveness of propranolol for treatment of infantile haemangioma2014
Curative effect study of pulsed dye laser in the treatment of 43 patients with hand infantile hemangioma-- Not Found --
Beneficial Effects of Early Treatment of Infantile Hemangiomas with a Long-Pulse Alexandrite Laser2014
Propranolol for the treatment of infantile haemangiomas: our experience with 44 patients2014
Long-Term Treatment with Oral Propranolol Reduces Relapses of Infantile Hemangiomas-- Not Found --
A new treatment pathway for propranolol use in infantile haemangiomas2014
Topical Propranolol Hydrochloride Gel for Superficial Infantile Hemangiomas2012
Endoscopic laser application in 56 children with hemangiomas of the larynx and trachea
Long term follow-up of intralesional laser photocoagulation (ILP) for hemangioma patients2011
Evaluation of safety and efficacy of a galenic preparation of 1% propranolol in 89 cases of cutaneous infantile hemangioma2013
Different modes cooling the epidermis with ice during Nd:YAG laser treatment of hemangiomas in children

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