- Low-Calorie Sweeteners and Health: An Evidence Map Database
- Low-calorie sweeteners (LCS), also known as sugar substitutes, non-nutritive sweeteners, or artificial sweeteners, are ingredients added to foods and beverages to provide sweetness without adding a significant amount of calories. A large body of literature evidence exists on low-calorie sweeteners yet the health effects of LCS beyond body weight or composition remain unknown and have not been systematically reviewed. As evidence and interest on LCS continues to grow, there is the need to understand the potential effects of low-calorie sweeteners. LCS evidence map is a database that collects the features and characteristics of the LCS studies. (Paper PMID:26728979). LCS database includes data on study design (study design and duration), population (baseline health status, age, sample size, anthropometrics), intervention/comparison (type of LCS, comparisons or control groups, numbers of people analyzed, forms of administration), and outcomes/study endpoint. In addition, study aim/hypothesis and funding source were also collected. (LCS Manual and database Code book available through: http://static-content.springer.com/esm/art%3A10.1186%2Fs12874-015-0105-z/MediaObjects/12874_2015_105_MOESM2_ESM.docx). Outcomes were also coded into clinically and biologically relevant outcome groups, classified by the research team and a stakeholder panel, to better describe data in the map (See Outcome Groups Table in the codebook).
• Provide a database of existing literature on LCS and health outcomes.
• Index key features and characteristics for quick summary report generation.
• Help identify LCS and health effect of interest and identify gaps in LCS research
• Systematically collect information to support further evidence synthesis
- Authors of Report
- Methodology description
- The goal of this Low-calorie sweetener evidence map is to provide existing low-calorie sweeteners studies readily in a database, describe the studies, and assist health researches in linking LCS to health outcomes efficiently.
The following six areas of research regarding the potential effects of LCS were all considered and included: 1) energy sensing by the brain, 2) gut hormones that may influence energy homeostasis, 3) taste preference and satiety, 4) Dietary intake, and 5) body weight and composition.
- LCS Method Paper PMID: 26728979
Data was entered retrospectively
- Funding Source
- Supported by North American branch of the International Life Sciences Institutes (ILSI), Carbohydrates Committee. More information on Low-calorie sweeteners can be found at: http://www.ilsi.org/NorthAmerica/Pages/LowCalorieSweeteners.aspx.