Blood Pressure Targets in CKD

Project Summary Title and Description

Title
Blood Pressure Targets in CKD
Description
Background: The optimal blood pressure target in patients with chronic kidney disease (CKD) is unclear. Purpose: To summarize trials comparing lower versus higher blood pressure targets in adult patients with CKD and focus on proteinuria as an effect modifier.
Attribution
N/A
Authors of Report
N/A
Methodology description
Data Sources: MEDLINE and the Cochrane Central Register of Controlled Trials (July 2001 through January 2011) were searched for reports from randomized, controlled trials with no language restriction. Study Selection: Authors screened abstracts to identify reports from trials comparing blood pressure targets in adults with CKD that had more than 50 participants per group; at least 1-year follow-up; and outcomes of death, kidney failure, cardiovascular events, change in kidney function, number of antihypertensive agents, and adverse events. Data Extraction: Reviewers extracted data on study design, methods, sample characteristics, interventions, comparators, outcomes, number of medications, and adverse events and rated study quality and quality of analyses for proteinuria subgroups.
PROSPERO
N/A
DOI
10.26300/mv9m-de53
Notes
Published Systematic Review: Upadhyay A, Earley A, Haynes S, Uhlig K. Systematic Review: Blood Pressure Target in Chronic Kidney Disease and Proteinuria as an Effect Modifier. Ann Intern Med. 2011 Apr 19; 154(8): 541-8 [PMID 21403055]
Funding Source
Kidney Disease: Improving Global Outcomes (KDIGO)

Key Questions

1. What is the optimal blood pressure target for patients with CKD?
2. What is the optimal blood pressure target for patients with CKD?
3. What effect does proteinuria have on blood pressure in patients with CKD?
4. What effect does proteinuria have on blood pressure in patients with CKD?
5. What is the optimal blood pressure target for patients with CKD?
6. What effect does proteinuria have on blood pressure in patients with CKD?
7. What is the optimal blood pressure target for patients with CKD?
8. What effect does proteinuria have on blood pressure in patients with CKD?
9. What effect does proteinuria have on blood pressure in patients with CKD?
10. What is the optimal blood pressure target for patients with CKD?
11. What effect does proteinuria have on blood pressure in patients with CKD?
12. What is the optimal blood pressure target for patients with CKD?
13. What effect does proteinuria have on blood pressure in patients with CKD?
14. What is the optimal blood pressure target for patients with CKD?
15. What effect does proteinuria have on blood pressure in patients with CKD?
16. What is the optimal blood pressure target for patients with CKD?
17. What is the optimal blood pressure target for patients with CKD?
18. What effect does proteinuria have on blood pressure in patients with CKD?
19. What effect does proteinuria have on blood pressure in patients with CKD?
20. What is the optimal blood pressure target for patients with CKD?
21. What effect does proteinuria have on blood pressure in patients with CKD?
22. What effect does proteinuria have on blood pressure in patients with CKD?
23. What is the optimal blood pressure target for patients with CKD?
24. What effect does proteinuria have on blood pressure in patients with CKD?
25. What is the optimal blood pressure target for patients with CKD?
26. What effect does proteinuria have on blood pressure in patients with CKD?
27. What is the optimal blood pressure target for patients with CKD?
28. What effect does proteinuria have on blood pressure in patients with CKD?
29. What is the optimal blood pressure target for patients with CKD?
30. What effect does proteinuria have on blood pressure in patients with CKD?
31. What is the optimal blood pressure target for patients with CKD?
32. What effect does proteinuria have on blood pressure in patients with CKD?

Associated Extraction Forms

Downloadable Data Content

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