Nonpharmacological Versus Pharmacological Treatments for Adult Patients With Major Depressive Disorder - Exercise Interventions

Project Summary Title and Description

Title
Nonpharmacological Versus Pharmacological Treatments for Adult Patients With Major Depressive Disorder - Exercise Interventions
Description
Comparison of the benefits and harms of second-generation antidepressants (SGAs), psychological treatment options as first-step interventions for adult outpatients with acute -phase major depressive disorder (MDD), and as second-step interventions for patients with MDD who did not achieve remission after a first treatment attempt with SGAs.
Attribution
N/A
Authors of Report
N/A
Methodology description
For the Systematic Review, we worked with a Technical Expert Panel representing the consumer perspective and professional organizations, researchers, and payers with expertise in psychopharmacology, psychotherapy, complementary and alternative medicine (CAM), and exercise therapies for depression, to finalize our methodological approach. Five literature databases were searched and dually screened following established inclusion/exclusion criteria. Individual trials were abstracted and dually rated for risk of bias. We qualitatively synthesized the data by each individual comparison eligible within each Key Question, and when data were sufficient we augmented findings with quantitative analyses. We graded the strength of evidence for outcomes deemed as important or critical for decisionmaking.
PROSPERO
N/A
DOI
10.26300/xbp6-t316
Notes
PMID of the project: 26764438 Link to project materials on the AHRQ website: https://effectivehealthcare.ahrq.gov/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productID=2155 Exercise is one of the three groups of treatments examined under this review, but due to the limitations of SRDR we have to enter each as a separate project. There are four Key Questions for the Systematic Review. Questions 5 through 9 are only used as a vehicle to be able to upload the data. Data were imported retrospectively into SRDR using the SRDR Data Import Tool.
Funding Source
Agency for Heatlhcare Quality and Research

Key Questions

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