Nonpharmacological Versus Pharmacological Treatments for Adult Patients With Major Depressive Disorder - Medication Strategies

Project Summary Title and Description

Title
Nonpharmacological Versus Pharmacological Treatments for Adult Patients With Major Depressive Disorder - Medication Strategies
Description
Comparison of the benefits and harms of second-generation antidepressants (SGAs), psychological treatment options as first-step interventions for adult outpatients with acute -phase major depressive disorder (MDD), and as second-step interventions for patients with MDD who did not achieve remission after a first treatment attempt with SGAs.
Attribution
N/A
Authors of Report
N/A
Methodology description
For the Systematic Review, we worked with a Technical Expert Panel representing the consumer perspective and professional organizations, researchers, and payers with expertise in psychopharmacology, psychotherapy, complementary and alternative medicine (CAM), and exercise therapies for depression, to finalize our methodological approach. Five literature databases were searched and dually screened following established inclusion/exclusion criteria. Individual trials were abstracted and dually rated for risk of bias. We qualitatively synthesized the data by each individual comparison eligible within each Key Question, and when data were sufficient we augmented findings with quantitative analyses. We graded the strength of evidence for outcomes deemed as important or critical for decisionmaking.
PROSPERO
N/A
DOI
10.26300/8pvb-7p46
Notes
PMID of the project: 26764438 Link to project materials on the AHRQ website: https://effectivehealthcare.ahrq.gov/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productID=2155 Medication switching or augmentation is one treatment strategy examined under this review, but due to the limitations of SRDR we have to enter each as a separate project. There are four Key Questions for the Systematic Review. Questions 5 through 10 are only used as a vehicle to be able to upload the data. Data were imported retrospectively into SRDR using the SRDR Data Import Tool.
Funding Source
Agency for Heatlhcare Quality and Research

Key Questions

1. KQ 2a. In adult patients with MDD who did not achieve remission following an initial adequate trial with one SGA, what is the comparative effectiveness of second-step therapies*? KQ 2b. Does comparative treatment effectiveness vary by MDD severity? * Any comparison that involves an eligible intervention (whether as a monotherapy or a combination therapy) and compares an intervention with one involving an SGA is eligible
2. Outcomes for KQ2a
3. Outcomes for KQ3 (for KQ2 Studies)
4. Outcomes for KQ2b

Associated Extraction Forms

Downloadable Data Content

Files
  • XLSX Project Data