Systematic Review of Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin

Project Summary Title and Description

Title
Systematic Review of Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin
Description
N/A
Attribution
N/A
Authors of Report
N/A
Methodology description
We conducted literature searches in MEDLINE®, the Cochrane Central Trials Registry and Cochrane Database of Systematic Reviews, and Embase® up to March 2017. We also perused the reference lists of published relevant clinical practice guidelines and systematic reviews. We recorded information on recurrence, histologic clearance, clinical clearance, patient- or observer-rated cosmetic outcomes, adverse effects, quality of life, costs and resources, mental health, patient satisfaction, and mortality. We estimated intervention effects (differences in outcomes between treatments) and the mean frequency of the outcome with each treatment using network meta-analyses.
PROSPERO
CRD42016043353
DOI
10.26300/hq0j-2w86
Notes
Report PMID 29533571 Data was entered into this project prospectively.
Funding Source
This report is based on research conducted by the Brown Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2015-00002-I).

Key Questions

1. Comparison of interventions
2. Comparison of interventions

Associated Extraction Forms

Associated Studies (each link opens a new tab)

TitleAuthorsYear
Fractionated 5-aminolaevulinic acid-photodynamic therapy vs. surgical excision in the treatment of nodular basal cell carcinoma: results of a randomized controlled trial.2008
Comparison of imiquimod 5% cream versus radiotherapy as treatment for eyelid basal cell carcinoma.2011
A phase III, randomized, open label study to evaluate the safety and efficacy of imiquimod 5% cream applied thrice weekly for 8 and 12 weeks in the treatment of low-risk nodular basal cell carcinoma.2007
The effect of intralesional 5-Fluorouracil Therapeutic Implant (MPI 5003) for treatment of basal cell carcinoma1992
Imiquimod 5% cream as pretreatment of Mohs micrographic surgery for nodular basal cell carcinoma in the face: a prospective randomized controlled study.2012
Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study.1997
Nonsurgical treatment of basal cell carcinomas with intralesional 5-fluorouracil/epinephrine injectable gel.1997
Cryotherapy of basal cell lesions.1979
The effect of intralesional interferon gamma on basal cell carcinomas.1990
Intralesional interferon therapy for basal cell carcinoma.1990
Treatment of basal-cell carcinoma: comparison of radiotherapy and cryotherapy.
The effect of an intralesional sustained-release formulation of interferon alfa-2b on basal cell carcinomas.1990
Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease.1996
Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream.1999
Cosmetic results of cryosurgery versus surgical excision for primary uncomplicated basal cell carcinomas of the head and neck.
Photodynamic therapy vs. cryosurgery of basal cell carcinomas: results of a phase III clinical trial.
Imiquimod 5% cream in the treatment of superficial basal cell carcinoma: results of a multicenter 6-week dose-response trial.2001
Surgical excision versus curettage plus cryosurgery in the treatment of basal cell carcinoma.
Efficacy of excisional surgery, curettage and combined curettage and electrodessication in treatment of basal cell carcinoma2012
A randomized trial comparing methyl aminolaevulinate photodynamic therapy with and without Er:YAG ablative fractional laser treatment in Asian patients with lower extremity Bowen disease: results from a 12-month follow-up.2014
Surgical excision versus Mohs; micrographic surgery for primary and recurrent basal-cell carcinoma of the face: a prospective randomised controlled trial with 5-years; follow-up.2008
Randomized comparison of photodynamic therapy with topical 5-fluorouracil in Bowen's disease.2003
Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial.2013
Imiquimod 5% cream for the treatment of superficial and nodular basal cell carcinoma: randomized studies comparing low-frequency dosing with and without occlusion.
Photodynamic therapy using topical methyl aminolevulinate vs surgery for nodular basal cell carcinoma: results of a multicenter randomized prospective trial.2004
Efficacy of topical 5% imiquimod cream for the treatment of nodular basal cell carcinoma: comparison of dosing regimens - 12 Week Study
Efficacy of topical 5% imiquimod cream for the treatment of nodular basal cell carcinoma: comparison of dosing regimens - 6 Week Study2002
Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: a double-blind, randomized, vehicle-controlled study.2002
Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from two phase III, randomized, vehicle-controlled studies.2004
5% imiquimod cream and reflectance-mode confocal microscopy as adjunct modalities to Mohs micrographic surgery for treatment of basal cell carcinoma.2004
Comparison of topical methyl aminolevulinate photodynamic therapy with cryotherapy or Fluorouracil for treatment of squamous cell carcinoma in situ: Results of a multicenter randomized trial.2006
Photodynamic therapy in combination with CO2 laser for the treatment of Bowen's disease.2015
Comparison of aminolevulinic acid (ALA)-thermogel-PDT with methyl-ALA-thermogel-PDT in basal cell carcinoma.2007
PEP005 (ingenol mebutate) gel for the topical treatment of superficial basal cell carcinoma: results of a randomized phase IIa trial.2010
Treatment of basal cell carcinoma with surgical excision and perilesional interferon-α.2013
Higher recurrence rates of head and neck nodular basal cell carcinoma treated with topical photodynamic therapy (MAL-PDT) compared to surgical excision: A randomized controlled study2015
Imiquimod 5% cream as adjunctive therapy for primary, solitary, nodular nasal basal cell carcinomas before Mohs micrographic surgery: a randomized, double blind, vehicle-controlled study.2009
Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial.2015
Effectiveness of a 595-nm pulsed dye laser for the treatment of basal cell carcinoma using 1 stacked-pulse session2014
Single treatment of non-melanoma skin cancers using a pulsed-dye laser with stacked pulses.2012
The effect of topical diclofenac 3% and calcitriol 3 μg/g on superficial basal cell carcinoma (sBCC) and nodular basal cell carcinoma (nBCC): A phase II, randomized controlled trial.2016
Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from a randomized vehicle-controlled phase III study in Europe.2005
Pilot study of imiquimod 5% cream as adjunctive therapy to curettage and electrodesiccation for nodular basal cell carcinoma.2006
Imiquimod 5% cream monotherapy for cutaneous squamous cell carcinoma in situ (Bowen's disease): a randomized, double-blind, placebo-controlled trial.
A randomized study of minimal curettage followed by topical photodynamic therapy compared with surgical excision for low-risk nodular basal cell carcinoma.2007
A clinical study comparing methyl aminolevulinate photodynamic therapy and surgery in small superficial basal cell carcinoma (8-20 mm), with a 12-month follow-up.2008
Topical methyl aminolaevulinate photodynamic therapy versus cryotherapy for superficial basal cell carcinoma: a 5 year randomized trial.2008
Photodynamic therapy with methyl aminolevulinate for primary nodular basal cell carcinoma: results of two randomized studies.2009
Er:YAG ablative fractional laser-primed photodynamic therapy with methyl aminolevulinate as an alternative treatment option for patients with thin nodular basal cell carcinoma: 12-month follow-up results of a randomized, prospective, comparative trial.2016
Similar effectiveness of methyl aminolevulinate and 5-aminolevulinate in topical photodynamic therapy for nodular basal cell carcinoma.2006
Photodynamic Therapy Followed by Mohs Micrographic Surgery Compared to Mohs Micrographic Surgery Alone for the Treatment of Basal Cell Carcinoma: Results of a Pilot Single-Blinded Randomised Controlled Trial.2015
Fractional laser-mediated photodynamic therapy of high-risk basal cell carcinomas--a randomized clinical trial.2015
Comparison of the effects of intralesional interferon alfa-2a, 2b and the combination of 2a and 2b in the treatment of basal cell carcinoma.1996
Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial.2014
Tumor recurrence 5 years after treatment of cutaneous basal cell carcinoma and squamous cell carcinoma.2013
Factors affecting the recurrence rate of basal cell carcinoma.2007
Evaluation of superficial basal cell carcinomas after treatment with imiquimod 5% cream or vehicle for apoptosis and lymphocyte phenotyping.2003
Effect of imiquimod as compared with surgery on the cancerization field in basal cell carcinoma.2014
Orthovoltage radiotherapy for nonmelanoma skin cancer (NMSC): Comparison between 2 different schedules.2016
A phase II, multicenter, open-label, 3-cohort trial evaluating the efficacy and safety of vismodegib in operable basal cell carcinoma.2015
Imiquimod 5% cream for the treatment of superficial and nodular basal cell carcinoma: randomized studies comparing low-frequency dosing with and without occlusion.2002
Fractional carbon dioxide laser improves nodular basal cell carcinoma treatment with photodynamic therapy with methyl 5-aminolevulinate.2013
Electronic brachytherapy for superficial and nodular basal cell carcinoma: a report of two prospective pilot trials using different doses.
Photodynamic therapy using topical 5-aminolaevulinic acid vs. surgery for basal cell carcinoma2012
The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas.2009
Comparison of cryotherapy with curettage in the treatment of Bowen's disease: a prospective study.2000
Fee comparisons of treatments for nonmelanoma skin cancer in a private practice academic setting.2012
Single treatment of low-risk basal cell carcinomas with pulsed dye laser-mediated photodynamic therapy (PDL-PDT) compared with photodynamic therapy (PDT): A controlled, investigator-blinded, intra-individual prospective study.2016
Effect of Methyl Aminolevulinate Photodynamic Therapy With and Without Ablative Fractional Laser Treatment in Patients With Microinvasive Squamous Cell Carcinoma: A Randomized Clinical Trial.2017

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