Device-modified trabeculectomy for glaucoma (2015)

Project Summary Title and Description

Device-modified trabeculectomy for glaucoma (2015)
OBJECTIVES: To assess the relative effectiveness, primarily with respect to IOP control and safety, of the use of different devices as adjuncts to trabeculectomy compared with standard trabeculectomy in eyes with glaucoma.
Authors of Report
Methodology description
SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register) (2014, Issue 12), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to December 2014), EMBASE (January 1980 to December 2014), PubMed (1948 to December 2014), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to December 2014), the metaRegister of Controlled Trials (mRCT) (, (, and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) ( We did not use any date or language restrictions in the electronic search for trials. We last searched the electronic databases on 22 December 2014. SELECTION CRITERIA: We included randomized controlled trials comparing devices used during trabeculectomy with trabeculectomy alone. We also included studies where antimetabolites were used in either or both treatment groups. DATA COLLECTION AND ANALYSIS: We used standard procedures expected by Cochrane.
PMID: 26625212 Data retrospectively entered into SRDR for public accessibility.
Funding Source

Key Questions

1. What is the effect of device-modified trabeculectomy for glaucoma?

Associated Extraction Forms

Associated Studies (each link opens a new tab)

Gelfilm® as a wound healing modulator in filtration surgery: a pilot study1998
Effect of amniotic membrane on trabeculectomy outcome in a prospective, randomized pilot study of patients at high risk for filtration failure2008
Modified trabeculectomy combined with amniotic membrane implantation for treatment of refractory glaucoma2012
Randomized-controlled trial of anti-scarring effectiveness on filtrating surgery combined with amniotic membrane [羊膜在小梁切除术中抗瘢痕作用的随机对照研究]2013
E-PTFE (Gore-Tex) implant with or without low-dosage mitomycin-C as an adjuvant in penetrating glaucoma surgery: 2 year randomized clinical trial.2008
Biodegradable collagen matrix implant vs mitomycin-C as an adjuvant in trabeculectomy: a 24-month, randomized clinical trial.2011
Comparison of trabeculectomy and Ex-PRESS implantation in fellow eyes of the same patient: a prospective, randomised study.2012
Ex-PRESS® tiva in patients with open angle glaucoma. A prospective comparison randomized 3-arms study.2005
The Ex-PRESS glaucoma shunt versus trabeculectomy in open-angle glaucoma: a prospective randomized study.2009
Use of amniotic membrane in trabeculectomy for the treatment of glaucoma: a pilot study.-- Not Found --
Trabeculectomy with use of amnion transplantation in glaucoma 2007
Comparison of trabeculectomy and trabeculectomy with amniotic membrane transplantation in the same patient with bilateral glaucoma.2013
Trabeculectomy With Mitomycin-C Versus Trabeculectomy With Amniotic Membrane Transplant: A Medium-term Randomized, Controlled Trial.2015
Clinical study of bio-amnion implantation used in combined trabeculectomy for refractory glaucoma2010
Clinical research of amniotic membrane transplantation in complex trabeculectomy for the treatment of refractory glaucoma2009
Comparative study of MMC augmented trabeculectomy vs an Ologen implant in open angle glaucoma
Subscleral trabeculectomy with mitomycin-C versus ologen for treatment of glaucoma.2013
To compare the outcome, complications and management of complications of trabeculectomy with Ologen implant versus trabeculectomy with MMC2012
Randomized, prospective, comparative trial of EX-PRESS glaucoma filtration device versus trabeculectomy (XVT study).2014
Trabeculectomy with OloGen versus trabeculectomy for the treatment of glaucoma: a pilot study.2010
Clinical study of bio-amnion implantation combined with trabeculectomy in angle-closure glaucoma [小梁切除联合生物羊膜植入术治疗闭角型青光眼的临床观察]2009
A prospective randomised trial of trabeculectomy using mitomycin C vs an ologen implant in open angle glaucoma.2010
Trabeculectomy using mitomycin C versus an atelocollagen implant: clinical results of a randomized trial and histopathologic findings.2014
Comparison of outcomes of trabeculectomy with mitomycin C vs. ologen implant in primary glaucoma.2013
Amniotic membrane transplantation in trabeculectomy with mitomycin C for refractory glaucoma.-- Not Found --
The use of amniotic membrane in trabeculectomy for the treatment of primary open-angle glaucoma: a prospective study.2012
Prospective Randomized Study Comparing Ex-PRESS to Trabeculectomy: 1-Year Results.-- Not Found --
Clinical trial of trabeculectomy with finished-product amniotic membrane transplantation2008
Trabeculectomy with mitomycin C and amniotic membrane transplantation and adjustable suture for refractory glaucoma2009
Trabeculectomy with use of amnion and releasable sutures for sclera flap in glaucoma.2004
A clinical applicative study of trabeculectomy with amniotic membrane transplanted2004
Clinical efficacy of trabeculectomy combined with sub-flap implantation with amniotic membrane preserved in glycerin for angle closure glaucoma2009
The comparison study of glaucoma trabeculectomy applying amniotic membrane or mitomycin C.2005

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