Lens extraction for chronic angle-closure glaucoma (2006)

Project Summary Title and Description

Lens extraction for chronic angle-closure glaucoma (2006)
Background: Angle-closure glaucoma is characterized by obstruction to the outflow of aqueous humor and consequent rise in intraocular pressure. The obstruction may result from an anatomical predisposition of the eye or may be due to pathophysiologic processes in any part of the eye. The former is considered the primary form and the latter a secondary form of angle closure. Relative pupillary block obstructing free flow of aqueous from the posterior chamber of the eye to the anterior chamber is considered to be the most common mechanism of angle closure. Crowding of the angle is another mechanism, which often coexists with pupillary block. This can result from an anterior placement of the lens due to an increase in the thickness of the lens (as occurs with aging), anterior displacement by a posterior force (for example choroidal effusion), or laxity of the zonules. Objectives: The objective of this review was to assess the effectiveness of lens extraction for chronic primary angle-closure glaucoma compared with other interventions for the condition in people without past history of acute-angle closure attacks.
Authors of Report
Methodology description
Search methods: We searched CENTRAL (2005, Issue 3), MEDLINE (1950 to April 2006), EMBASE (1980 to April 2006), and LILACS (to August 2005). We searched the reference lists of included studies and used the Science Citation Index database. Selection criteria: In the absence of any randomized trials we included non-randomized studies comparing lens extraction with other treatment modalities for chronic primary angle-closure glaucoma including, but not limited to, laser iridotomy, medications, and laser iridoplasty. We excluded studies with a case-series design. Data collection and analysis: Two authors independently extracted data on methodological quality of the included studies, outcomes for the review, and study characteristics including participant characteristics, interventions, and sources of funding. Differences were resolved through discussion.
Full report available at: https://www.ncbi.nlm.nih.gov/pubmed/16856103; PMID: 16856103; PMCID: PMC4438535 Data retrospectively entered into SRDR for public accessibility.
Funding Source
National Eye Institute, National Institutes of Health, USA (Contract N-01-EY2-1003)

Key Questions

1. What is the effect of lens extraction for chronic angle-closure glaucoma?

Associated Extraction Forms

Downloadable Data Content

  • XLSX Project Data