Medical interventions for acanthamoeba keratitis (2015)

Project Summary Title and Description

Medical interventions for acanthamoeba keratitis (2015)
OBJECTIVES: To evaluate the relative effectiveness and safety of medical therapy for the treatment of AK.
Authors of Report
Methodology description
SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2015, Issue 1), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to January 2015), EMBASE (January 1980 to January 2015), PubMed (1948 to January 2015), Latin American and Caribbean Health Sciences Literature Database (LILACS) (1982 to January 2015), the metaRegister of Controlled Trials (mRCT) (, ( and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) ( We did not use any date or language restrictions in the electronic search for trials. We last searched the electronic databases on 9 January 2015. SELECTION CRITERIA: We included randomized controlled trials (RCTs) of medical therapy for AK, regardless of the participants' age, sex, or etiology of disease. We included studies that compared either anti-amoeba therapy (drugs used alone or in combination with other medical therapies) with no anti-amoeba therapy or one anti-amoeba therapy with another anti-amoeba therapy. DATA COLLECTION AND ANALYSIS: Two authors independently screened search results and full-text reports, assessed risk of bias, and abstracted data. We used standard methodological procedures as set forth by the Cochrane Collaboration.
Available on PubMed at; PMID: 25710134; PMCID: PMC4730543 Data retrospectively entered into SRDR for public accessibility.
Funding Source
Grant 1 U01 EY020522, National Eye Institute, National Institutes of Health, USA

Key Questions

1. What are the medical interventions for acanthamoeba keratitis?

Associated Extraction Forms

Downloadable Data Content

  • XLSX Project Data