Anxiety in Children

Project Summary Title and Description

Title
Anxiety in Children
Description
To evaluate the comparative effectiveness and safety of treatments for childhood anxiety disorders, including panic disorder, social anxiety disorder, specific phobias, generalized anxiety disorder, and separation anxiety. PubMed ID: Data were entered into this project retrospectively using a PDF format files, including studies characteristics, binary outcomes, continuous outcomes, withdraw outcomes and studies quality.
Attribution
N/A
Authors of Report
N/A
Methodology description
We searched MEDLINE, EMBASE, PsycINFO, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and SciVerse Scopus through February 1, 2017; and reviewed bibliographies and the grey literature. We included randomized and non-randomized comparative studies that compared psychotherapy, pharmacotherapy, or a combination in children between 3 and 18 years old with panic disorder, social anxiety disorder, specific phobias, generalized anxiety disorder, or separation anxiety. Pairs of independent reviewers selected studies using pre-specified inclusion and exclusion criteria
PROSPERO
CRD42016046542
DOI
10.26300/x3e1-5429
Notes
Attached files: Continuous Outcomes.pdf: has Continuous outcomes (Primary anxiety scales, Function, Secondary measure, Social function) Binary Ourcoms.pdf: has Binary Outcomes (Remission, Response, adverse events) Baseline Characteristics.pdf: has Baseline Characteristics of the included studies Quality.pdf: has quality assessment of the included studies withdrawal.pdf: has the dropout outcome
Funding Source
AHRQ

Key Questions

1. What is the comparative effectiveness of the available treatments for childhood anxiety disorders, including panic disorder, social anxiety disorder, specific phobias, generalized anxiety disorder, and separation anxiety?
2. What are the comparative harms and safety concerns regarding the available treatments for childhood anxiety disorders, including panic disorder, social anxiety disorder, specific phobias, generalized anxiety disorder, and separation anxiety?

Associated Extraction Forms

Associated Studies (each link opens a new tab)

TitleAuthorsYear
Sequential pharmacotherapy for children with comorbid attention-deficit/hyperactivity and anxiety disorders.2005
Eight years later: outcomes of CBT-treated versus untreated anxious children.2014
The effective comparison between emotion-focused cognitive behavioral group therapy and cognitive behavioral group therapy in children with separation anxiety disorder.2014
Sleep-related problems among children and adolescents with anxiety disorders.2007
Efficacy of a Danish version of the Cool Kids program: a randomized wait-list controlled trial.2015
Effectiveness of Acceptance and Commitment Therapy on Interpersonal Problems and Psychological Flexibility in Female High School Students With Social Anxiety Disorder.
Pilot study of community-based cognitive behavioral group therapy for adolescents with social phobia.2005
Family treatment of childhood anxiety: a controlled trial.1996
Evaluation of cognitive-behavioral group treatments for childhood anxiety disorders.1998
Behavioral treatment of childhood social phobia.2000
SET-C versus fluoxetine in the treatment of childhood social phobia.2007
Imipramine plus cognitive-behavioral therapy in the treatment of school refusal.2000
Clonazepam in the treatment of prepubertal children with panic-like symptoms.1987
Fluoxetine for the treatment of childhood anxiety disorders.2003
Fluoxetine for childhood anxiety disorders.
Treatment of elective mutism with fluoxetine: a double-blind, placebo-controlled study.
Child versus family cognitive-behavioral therapy in clinically anxious youth: an efficacy and partial effectiveness study.
Costs and cost-effectiveness of family CBT versus individual CBT in clinically anxious children.2008
Training-associated changes and stability of attention bias in youth: Implications for Attention Bias Modification Treatment for pediatric anxiety.
Guided parent-delivered cognitive behaviour therapy for children with anxiety disorders: Outcomes at 3- to 5-year follow-up.2017
A new parenting-based group intervention for young anxious children: results of a randomized controlled trial.2011
Treating anxiety disorders in children with high functioning autism spectrum disorders: a controlled trial.2007
Feasibility of two modes of treatment delivery for child anxiety in primary care.2014
Combined psychoeducation and treatment with selective serotonin reuptake inhibitors for youth with generalized social anxiety disorder.2002
Effectiveness of modular CBT for child anxiety in elementary schools.2013
Adaptol in the treatment of anxiety disorders in children with school maladaptation.2010
The role of parental anxiety in the treatment of childhood anxiety.1998
Do anxiety-disordered children need to come into the clinic for efficacious treatment?2012
Sertraline in children and adolescents with social anxiety disorder: an open trial.2001
The Effectiveness of Emotive Imagery in the Treatment of Darkness Phobia in Children1996
Treatment of childhood anxiety disorder in the context of maternal anxiety disorder: a randomised controlled trial and economic analysis.2015
Comparison among clomipramine, fluoxetine, and placebo for the treatment of anxiety disorders in children and adolescents.2013
Chlordiazepoxide in management of school phobia.1962
Individual versus group family-focused cognitive-behaviour therapy for childhood anxiety: pilot randomized controlled trial.2007
Computer-aided vicarious exposure versus live graded exposure for spider phobia in children.2001
Intensive group-based CBT for child social phobia: a pilot study.
Online CBT for preschool anxiety disorders: a randomised control trial.2014
Fluoxetine treatment of children with selective mutism: an open trial.1996
The Effectiveness of Mindfulness-Based Cognitive Therapy on Iranian Female Adolescents Suffering From Social Anxiety.2016
Worried no more: The effects of medication status on treatment response to a CBT group for children with anxiety in a community setting.2011
Attention bias modification treatment for pediatric anxiety disorders: a randomized controlled trial.2012
Parental changes after involvement in their anxious child's cognitive behavior therapy.2014
Open fluoxetine treatment of mixed anxiety disorders in children and adolescents.1997
Group and individual cognitive-behavioral treatments for youth with anxiety disorders: A randomized clinical trial.2000
Group and individual cognitive-behavioral treatments for youth with anxiety disorders: 1-Year follow-up2005
A brief group cognitive-behavioral intervention for social phobia in childhood.2004
The impact of an 8-day intensive treatment for adolescent panic disorder and agoraphobia on comorbid diagnoses.2012
Can parent training for parents with high levels of expressed emotion have a positive effect on their child's social anxiety improvement?2014
Atomoxetine treatment for pediatric patients with attention-deficit/hyperactivity disorder with comorbid anxiety disorder.2007
Treating Anxiety Disorders in Inner City Schools: Results from a Pilot Randomized Controlled Trial Comparing CBT and Usual Care.2012
School-based treatment for anxious african-american adolescents: a controlled pilot study.2002
Remission after acute treatment in children and adolescents with anxiety disorders: findings from the CAMS.
A randomized controlled trial of multimodal music therapy for children with anxiety disorders.2012
Parental anxiety as a predictor of medication and CBT response for anxious youth.2015
Short-term psychoanalytic child therapy for anxious children: a pilot study.2014
Clonazepam in childhood anxiety disorders.-- Not Found --
Long-term outcomes of brief, intensive CBT for specific phobias: The negative impact of ADHD symptoms.2016
Phobic children one and two years posttreatment.1973
Acceptance and Commitment Therapy versus Cognitive Behavior Therapy for Children With Anxiety: Outcomes of a Randomized Controlled Trial.
Cognitive-behavioral group therapy for social phobia in female adolescents: results of a pilot study.2000
Cognitive behavior therapy for generalized social anxiety disorder in adolescents: a randomized controlled trial.2009
The effect of targeting tolerance of children's negative emotions among anxious parents of children with anxiety disorders: A pilot randomised controlled trial.2016
Cognitive behavioral therapy for 4- to 7-year-old children with anxiety disorders: a randomized clinical trial.2010
The efficacy of a group-based, disorder-specific treatment program for childhood GAD--a randomized controlled trial.
The impact of brief parental anxiety management on child anxiety treatment outcomes: a controlled trial.2014
Cognitive-behavioral treatment versus an active control for children and adolescents with anxiety disorders: a randomized trial.
A randomized controlled trial of an audio-based treatment program for child anxiety disorders.2016
A randomized controlled trial of individual cognitive therapy, group cognitive behaviour therapy and attentional placebo for adolescent social phobia.2014
Cognitive behavioural therapy for Japanese children and adolescents with anxiety disorders: a pilot study.2012
An open-label trial of escitalopram in children and adolescents with social anxiety disorder.2007
The efficacy of a cognitive-behavioral group treatment for children and adolescents with social phobia: A controlled trial.2002
The efficacy of attendance and semi-attendance group cognitive-behavioral therapy (CBT) on the anxiety disorders of adolescent girls.2010
Benefits of child-focused anxiety treatments for parents and family functioning.2013
Therapy for youths with anxiety disorders: a second randomized clinical trial.1997
Cognitive-behavioral therapy for anxiety disordered youth: a randomized clinical trial evaluating child and family modalities.
Computer-assisted cognitive behavioral therapy for child anxiety: results of a randomized clinical trial.2010
Exploring the role of parent training in the treatment of childhood anxiety.2009
Interpretation modification training reduces social anxiety in clinically anxious children.2015
Imipramine treatment of children with separation anxiety disorder.1992
Cognitive-behavioral treatment of school phobia.1998
School-Based Interventions for Anxious Children: Long-Term Follow-Up.2016
Comparing different modes of delivery: a pilot evaluation of a family-focused, cognitive-behavioral intervention for anxiety-disordered children.2009
Citalopram in the treatment of early-onset panic disorder and school phobia.1996
Changes in facial electromyographic activity in spider-phobic girls after psychotherapy.2012
Examining the relation between the therapeutic alliance, treatment adherence, and outcome of cognitive behavioral therapy for children with anxiety disorders.2010
No differences between group versus individual treatment of childhood anxiety disorders in a randomised clinical trial.2008
Evaluation of therapist-supported parent-implemented CBT for anxiety disorders in rural children.2006
Group and individual cognitive-behavioral therapy for childhood anxiety disorders: a randomized trial.2002
Serotonergic agents in the treatment of social phobia in children and adolescents: a case series.1999
A Randomized controlled trial of venlafaxine ER versus placebo in pediatric social anxiety disorder.2007
The efficacy of an internet-based cognitive-behavioral therapy intervention for child anxiety disorders.2009
Paroxetine in child and adolescent outpatients with panic disorder.2001
Treating adolescents with social anxiety disorder in school: an attention control trial.2007
School-based intervention for adolescents with social anxiety disorder: results of a controlled study.2005
Group therapy for anxiety in children with autism spectrum disorder.2014
The Coping Cat program for children with anxiety and autism spectrum disorder: a pilot randomized controlled trial.2013
Cognitive behavioral therapy of socially phobic children focusing on cognition: a randomised wait-list control study.2011
Augmenting Cognitive Behavior Therapy for School Refusal with Fluoxetine: A Randomized Controlled Trial.
Cognitive-behavioral group treatments in childhood anxiety disorders: the role of parental involvement.1999
A comparison of in vivo and vicarious exposure in the treatment of childhood water phobia.1993
Comparison of reciprocal inhibition, psychotherapy, and waiting list control for phobic children.1972
Short- and long-term effects of a cognitive-behavioural training programme for children with social anxiety.2011
Comparison of child-parent and parent-only cognitive-behavioral therapy programs for anxious children aged 5 to 7 years: short- and long-term outcomes.2015
The revised version of the Screen for Child Anxiety Related Emotional Disorders (SCARED-R): treatment sensitivity in an early intervention trial for childhood anxiety disorders.2001
Treatment of childhood anxiety disorders: a preliminary comparison between cognitive-behavioral group therapy and a psychological placebo intervention.-- Not Found --
Treating phobic children: effects of EMDR versus exposure.1998
Cognitive coping vs emotional disclosure in the treatment of anxious children: A pilot-study. 2002
Cognitive-behavioral therapy for children with anxiety disorders in a clinical setting: no additional effect of a cognitive parent training.2003
Pilot study on the effectiveness of systematic desensitization with neurologically impaired children with phobic disorders.1970
Group cognitive behavioural therapy for children with anxiety disorder - An evaluation of the 'Friends for Youth' programme.2007
The contribution of the therapist's competence in the treatment of adolescents with generalized social phobia.2014
Results at long-term among three psychological treatments for adolescents with generalized social phobia (I): Statistical significance. 2002
Specific phobias in youth: a randomized controlled trial comparing one-session treatment to a parent-augmented one-session treatment.2015
One-session treatment of specific phobias in youth: a randomized clinical trial in the United States and Sweden.
One-Session treatment of specific phobias in youths: a randomized clinical trial.
Behavioral treatment of social phobia in youth: does parent education training improve the outcome?2015
Social anxiety in adolescents: the effect of video feedback on anxiety and the self-evaluation of performance.-- Not Found --
Attention bias modification for youth with social anxiety disorder.
24- and 36-week outcomes for the Child/Adolescent Anxiety Multimodal Study (CAMS).2014
Cognitive-behavioral treatment of panic disorder in adolescence.2010
Fluvoxamine for the treatment of anxiety disorders in children and adolescents.2001
Bibliotherapy for children with anxiety disorders using written materials for parents: A randomized controlled trial.
Not Found - Please check PubMed ID for accuracy.2009
Activation adverse events induced by the selective serotonin reuptake inhibitor fluvoxamine in children and adolescents.
Selective serotonin reuptake inhibitor-induced apathy: a pediatric case series.-- Not Found --
Use of selective serotonin reuptake inhibitors for the treatment of childhood panic disorder: a pilot study.1999
Effectiveness of reboxetine in treatment of outpatient children and adolescents with attention deficit-hyperactivity disorder with comorbid anxiety disorders.2013
The group desensitization of children's snake phobias using vicarious and contact desensitization procedures.1968
Efficacy and safety of extended-release venlafaxine in the treatment of generalized anxiety disorder in children and adolescents: two placebo-controlled trials.2007
Placebo-controlled trial of sertraline in the treatment of children with generalized anxiety disorder.
Child/Adolescent anxiety multimodal study: evaluating safety.2015
A randomized controlled trial of the child anxiety multi-day program (CAMP) for separation anxiety disorder.2013
Do pharmacological and behavioral interventions differentially affect treatment outcome for children with social phobia?2011
Disorder-specific cognitive-behavioral therapy for separation anxiety disorder in young children: a randomized waiting-list-controlled trial.2011
The efficacy of a family-based cognitive-behavioral treatment for separation anxiety disorder in children aged 8-13: a randomized comparison with a general anxiety program.2013
Evaluating the FRIENDS program: a cognitive-behavioral group treatment for anxious children and their parents.2001
A Randomized Clinical Trial Comparing Individual Cognitive Behavioral Therapy and Child-Centered Therapy for Child Anxiety Disorders.2016
Treating anxiety disorders in children with group cognitive-behaviorial therapy: a randomized clinical trial.
Directionality of change in youth anxiety treatment involving parents: an initial examination.2009
Alprazolam effects in children with anxiety disorders.1987
Cognitive behavioral and attachment based family therapy for anxious adolescents: Phase I and II studies.2005
Parent cognitive-behavioral intervention for the treatment of childhood anxiety disorders: a pilot study.2014
Does cognitive behavioral therapy for youth anxiety outperform usual care in community clinics? An initial effectiveness test.2010
The treatment of childhood social phobia: the effectiveness of a social skills training-based, cognitive-behavioural intervention, with and without parental involvement.2000
A randomized controlled trial of online versus clinic-based CBT for adolescent anxiety.2011
Generic versus disorder specific cognitive behavior therapy for social anxiety disorder in youth: A randomized controlled trial using internet delivery.
The feasibility and outcome of clinic plus internet delivery of cognitive-behavior therapy for childhood anxiety.
Is virtual reality effective to motivate and raise interest in phobic children toward therapy? A clinical trial study of in vivo with in virtuo versus in vivo only treatment exposure.2010
The effect of cognitive-behavioral therapy versus treatment as usual for anxiety in children with autism spectrum disorders: a randomized, controlled trial.2013
A RANDOMIZED CONTROLLED TRIAL IN COMMUNITY MENTAL HEALTH CENTERS OF COMPUTER-ASSISTED COGNITIVE BEHAVIORAL THERAPY VERSUS TREATMENT AS USUAL FOR CHILDREN WITH ANXIETY.
A randomized, placebo-controlled study of duloxetine for the treatment of children and adolescents with generalized anxiety disorder.
Cognitive-behavioral therapy for anxiety-disordered youth: secondary outcomes from a randomized clinical trial evaluating child and family modalities.2009
Treatment of child anxiety disorders via guided parent-delivered cognitive-behavioural therapy: randomised controlled trial.2013
A randomized trial of Internet-delivered treatment for social anxiety disorder in high school students.2011
Self-talk in youth with anxiety disorders: states of mind, content specificity, and treatment outcome.1996
CBT for anxiety disorders in children with and without autism spectrum disorders. 2015
Cost-effectiveness of cognitive-behavioral therapy versus treatment as usual for anxiety disorders in children with autism spectrum disorder. 2014
Internet-delivered cognitive behavioural therapy for children with anxiety disorders: A randomised controlled trial.
Long-term outcomes and predictors of internet-delivered cognitive behavioral therapy for childhood anxiety disorders.2017
Parental Involvement in Cognitive Behavior Therapy for Children with Anxiety Disorders: 3-Year Follow-Up.2017
Treatment of pediatric anxiety disorders: an open-label extension of the research units on pediatric psychopharmacology anxiety study.2002
Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety.2008
Cognitive-behavioral treatment of persistent functional somatic complaints and pediatric anxiety: an initial controlled trial.
Augmenting one-session treatment of children's specific phobias with attention training to positive stimuli.2014
Cognitive-behavioural therapy for young children with anxiety disorders: Comparison of a Child + Parent condition versus a Parent Only condition.2009
Attention training towards positive stimuli in clinically anxious children.2013
Look for good and never give up: A novel attention training treatment for childhood anxiety disorders.
An effectiveness study of individual vs. group cognitive behavioral therapy for anxiety disorders in youth.2014
Predictors of treatment outcome in an effectiveness trial of cognitive behavioral therapy for children with anxiety disorders.2016
Randomized controlled trial: Multimodal Anxiety and Social Skill Intervention for adolescents with autism spectrum disorder.2013
The feasibility of improving CBT for childhood anxiety disorders through a dismantling study.2015
Brief report: effects of cognitive behavioral therapy on parent-reported autism symptoms in school-age children with high-functioning autism.2009
Cognitive behavioral therapy for anxiety in children with autism spectrum disorders: a randomized, controlled trial.2009
Family cognitive behavioral therapy for child anxiety disorders.2006
A randomized controlled trial of the Cool Teens CD-ROM computerized program for adolescent anxiety.2012
Effects of cognitive-behavioral therapy on improving anxiety symptoms, behavioral problems and parenting stress in Taiwanese children with anxiety disorders and their mothers.2014
Treating social phobia in children through group narrative therapy.2014
Buspirone use in an adolescent with social phobia and mixed personality disorder (cluster A type).1994
The effective comparison between modular cognitive behavioral therapy (MCBT) and child-parent relationship training (CPRT) in children with separation anxiety symptoms2016
Role of the focus of attention in the treatment of generalized social phobia in adolescents2011
Competencia social y autoestima en adolescentes con fobia social2014
Treatment of adolescent panic disorder: A nonrandomized comparison of intensive versus weekly CBT2012
Moderators of intensive CBT for adolescent panic disorder: the of fear and avoidance.2016
Intensive cognitive behavioral therapy for anxiety disorders in school-aged children with autism: A preliminary comparison with treatment-as-usual2013
Cognitive-behavioural treatment in Mexican children with social phobia
School phobia: diagnostic considerations in the light of imipramine effects.1973
2001
Treating anxiety disorders in children: results of a randomized clinical trial.1994
Can school counselors deliver cognitive-behavioral treatment for social anxiety effectively? A randomized controlled trial.2016
Psychological treatment of the phobia of the dark in a game situation: A controlled essay2003
Academic impairment and impact of treatments among youth with anxiety disorders2015
Cognitive-behavioural therapy for anxiety disordered children in a clinical setting: Does additional cognitive parent training enhance treatment effectiveness?2001
Does individual attention improve the effect of group treatment of adolescents with social phobia? 2008
The relevance of the individualized attention in the treatment with adolescents under generalized social phobia2006
Effects of a cognitive behavioral training program for children with social anxiety2009
Is triple p positive parenting program effective on anxious children and their parents? 4th month follow up results2015
Group treatment of children with anxiety disorders: Outcome and predictors of treatment response2000
Treatment for comorbid pediatric gastrointestinal and anxiety disorders: A pilot study of a flexible health sensitive cognitive-behavioral therapy program2015
Early detection and treatment of adolescents with generalized social phobia2005
The role of non-specific effects in the psychological treatment of adolescents with social phobia2009
Contributions of cognitive restructuring in the treatment of social phobia in adolescents2013
Intervención temprana en niños y adolescentes con fobia social. Anuario de psicología2009
Effectiveness of a program for early detection/intervention in children/adolescents with generalized social phobia2009
Play therapy applied by parents for children with darkness phobia: comparison of two programmes2006
Buspirone Therapy of Mixed Anxiety Disorders in Childhood and Adolescence - a Pilot-Study1994
A multicenter, randomized, double-blind, placebo-controlled trial of paroxetine in children and adolescents with social anxiety disorder.2004

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