Nonsurgical Treatments for Urinary Incontinence in Adult Women: A Systematic Review Update

Project Summary Title and Description

Title
Nonsurgical Treatments for Urinary Incontinence in Adult Women: A Systematic Review Update
Description
SR of nonsurgical interventions for stress, urgency, and mixed urinary incontinence in women (excluding neuropathic UI and children). Network meta-analysis of "urinary incontinence outcomes" ("cure", improvement, and satisfaction with the level of incontinence achieved). Qualitative review of quality of life outcomes. Summary of adverse events. This is an update of a 2012 review done by the Minnesota EPC. Available data from eligible studies included in the prior review are uploaded as separate files.
Attribution
N/A
Authors of Report
N/A
Methodology description
We updated AHRQ’s 2012 systematic review with new literature searches in MEDLINE, the Cochrane Central Trials Registry, the Cochrane Database of Systematic Reviews, and EMBASE from 2011 through December 4, 2017. We included UI outcomes (cure, improvement, satisfaction), quality of life, and adverse events. For UI outcomes, we conducted network meta-analyses, combining direct and indirect comparisons across studies. Quality of life and adverse event outcomes are narratively described. See full report at AHRQ website for further details.
PROSPERO
CRD42017069903
DOI
10.26300/2ed7-vz39
Notes
The SRDR files (direct extraction into SRDR) contain new studies since the 2012 Minnesota report and some older studies that had been missed or were incompletely extracted. Only "UI outcomes" are extracted in full in SRDR. Files attached to this project contain other studies from the Minnesota report (that were eligible for this update) and extractions of quality of life and adverse events for all studies.
Funding Source
AHRQ EPC Program

Key Questions

1. KQ 1: What are the benefits and harms of nonpharmacological treatments of UI in women, and how do they compare with each other? KQ 2: What are the benefits and harms of pharmacological treatments of UI in women, and how do they compare with each other? KQ 3: What are the comparative benefits and harms of nonpharmacological versus pharmacological treatments of UI in women? KQ 4: What are the benefits and harms of combined nonpharmacological and pharmacological treatment of UI in women?

Associated Extraction Forms

Associated Studies (each link opens a new tab)

TitleAuthorsYear
Behavioral Intervention Program versus Vaginal Cones on Stress Urinary Incontinence and Related Quality of Life: A Randomized Clinical Trial.2014
Comparison of mindfulness-based stress reduction versus yoga on urinary urge incontinence: a randomized pilot study. with 6-month and 1-year follow-up visits.
Oxybutynin and tolterodine in a trial for treatment of overactive bladder in Iranian women.2014
Combined Vaginal Pelvic Floor Electrical Stimulation (PFS) and Local Vaginal Estrogen for Treatment of Overactive Bladder (OAB) in Perimenopausal Females. Randomized Controlled Trial (RCT).
OnabotulinumtoxinA vs Sacral Neuromodulation on Refractory Urgency Urinary Incontinence in Women: A Randomized Clinical Trial.2016
Randomized trial of a comparison of rehabilitation or drug therapy for urgency urinary incontinence: 1-year follow-up.2013
Tolterodine ER reduced increased bladder wall thickness in women with overactive bladder. A randomized, placebo-controlled, double-blind, parallel group study.
Comparison of Side Effects of Solifenacin Vs Tolteridine in Patients with Urinary Incontinence2016
Considering the prominent complaint as a guide in medical therapy for overactive bladder syndrome in women over 45 years.2015
Anticholinergic therapy vs. onabotulinumtoxina for urgency urinary incontinence.2012
A phase 2, randomized, double-blind, efficacy and safety study of oxybutynin vaginal ring for alleviation of overactive bladder symptoms in women2014
Pharmacologic treatment for urgency-predominant urinary incontinence in women diagnosed using a simplified algorithm: a randomized trial.2012
Efficacy and safety of polyacrylamide hydrogel for the treatment of female stress incontinence: a randomized, prospective, multicenter North American study.2014
Exercise programmes for women with stress urinary incontinence2012
Effect of pelvic floor muscle training compared with watchful waiting in older women with symptomatic mild pelvic organ prolapse: randomised controlled trial in primary care.
Effects of intravaginal estriol and pelvic floor rehabilitation on urogenital aging in postmenopausal women.
A randomized, controlled clinical trial of a novel intravesical pressure attenuation device for the treatment of stress urinary incontinence2013
Effects of exercise treatment with or without heat and steam generating sheet on urine loss in community-dwelling Japanese elderly women with urinary incontinence.2011
The effects of multidimensional exercise treatment on community-dwelling elderly Japanese women with stress, urge, and mixed urinary incontinence: a randomized controlled trial.2011
Evaluation of a new disposable "tampon like" electrostimulation technology (Pelviva®) for the treatment of urinary incontinence in women: a 12-week single blind randomized controlled trial.
Short-term effect of adding pelvic floor muscle training to bladder training for female urinary incontinence: a randomized controlled trial.2015
The efficacy and safety of solifenacin in patients with overactive bladder syndrome.
Is home-based pelvic floor muscle training effective in treatment of urinary incontinence after birth in primiparous women? A randomized controlled trial.2013
Outpatient biofeedback in addition to home pelvic floor muscle training for stress urinary incontinence: a randomized controlled trial.
Pulsed Magnetic Stimulation for Stress Urinary Incontinence: 1-Year Followup Results.2017
Investigation of the clinical efficacy and safety of pregabalin alone or combined with tolterodine in female subjects with idiopathic overactive bladder.2011
Urodynamic results and clinical outcomes with intradetrusor injections of onabotulinumtoxinA in a randomized, placebo-controlled dose-finding study in idiopathic overactive bladder.2011
Clinical safety, tolerability and efficacy of combination tolterodine/pilocarpine in patients with overactive bladder.2014
Safety and Efficacy Study of a New Treatment for Symptoms of Urinary Incontinence
What is the success of drug treatment in urge urinary incontinence? What should be measured?2013
Web-based trial to evaluate the efficacy and safety of tolterodine ER 4 mg in participants with overactive bladder: REMOTE trial.2014
Treatment of Stress Urinary Incontinence Via Smartphone
Efficacy of Botulinum Toxin A Intradetrusor Injections for Non-neurogenic Urinary UrgE Incontinence: A Randomized Double-Blind Controlled Trial2013
Comparison of different treatment protocols in the treatment of idiopathic detrusor overactivity: a randomized controlled trial.
Comparison of two selective muscarinic receptor antagonists (solifenacin and darifenacin) in women with overactive bladder--the SOLIDAR study.2012
Effect of fesoterodine on urethral closure function in women with stress urinary incontinence assessed by urethral pressure reflectometry.2014
The concomitant use of fesoterodine and topical vaginal estrogen in the management of overactive bladder and sexual dysfunction in postmenopausal women.
Pelvic floor muscle training for stress urinary incontinence: a randomized, controlled trial comparing different conservative therapies.2011
Efficacy of Electrical Pudendal Nerve Stimulation versus Transvaginal Electrical Stimulation in Treating Female Idiopathic Urgency Urinary Incontinence.2017
Pelvic static magnetic stimulation to control urinary incontinence in older women: a randomized controlled trial.2012
A Pilot Randomized Placebo Controlled Trial of Electroacupuncture for Women with Pure Stress Urinary Incontinence.
Low-Dose Intravaginal Estriol and Pelvic Floor Rehabilitation in Post-Menopausal Stress Urinary Incontinence.2015
Incontinence improves in older women after intensive pelvic floor muscle training: an assessor-blinded randomized controlled trial.2011
Development of a pelvic floor muscle strength evaluation device.
Pelvic floor muscle training in women with stress urinary incontinence causes hypertrophy of the urethral sphincters and reduces bladder neck mobility during coughing.2013
Randomized controlled trial of physiotherapy for postpartum stress incontinence: 7-year follow-up.2013
Role of Pelvic Floor Muscle Therapy in Obese Perimenopausal Females with Stress Incontinence: A Randomized Control Trial2012
75NC007 device for noninvasive stress urinary incontinence management in women: a randomized controlled trial.2012
Effectiveness of a new standardised Urinary Continence Physiotherapy Programme for community-dwelling older women in Hong Kong.2015
Comparison of the efficacy of perineal and intravaginal biofeedback assisted pelvic floor muscle exercises in women with urodynamic stress urinary incontinence.2017
The efficacy and safety of PSD503 (phenylephrine 20%, w/w) for topical application in women with stress urinary incontinence. A phase II, multicentre, double-blind, placebo controlled, 2-way cross over study.
The concomitant use of fesoterodine and topical vaginal estrogen in the management of overactive bladder and sexual dysfunction in postmenopausal women.2016
A randomised controlled trial of transabdominal ultrasound biofeedback for pelvic floor muscle training in older women with urinary incontinence2013
Transvaginal electrical stimulation with surface-EMG biofeedback in managing stress urinary incontinence in women of premenopausal age: a double-blind, placebo-controlled, randomized clinical trial.
Efficacy impacts of the different treatment frequencies on female stress urinary incontinence.2013
The improvement in pelvic floor symptoms with weight loss in obese women does not correlate with the changes in pelvic anatomy.2014
Effects of surface and intravaginal electrical stimulation in the treatment of women with stress urinary incontinence: randomized controlled trial.2014
Continuous improvement of portable domestic pelvic floor neuromuscular electrical stimulation on the pelvic floor function of patients with urinary incontinence.2015
Effect of vaginal spheres and pelvic floor muscle training in women with urinary incontinence: a randomized, controlled trial.2015
Using the Vibrance Kegel Device With Pelvic Floor Muscle Exercise for Stress Urinary Incontinence: A Randomized Controlled Pilot Study.2015
Effect of Sacral Neuromodulation Rate on Overactive Bladder Symptoms: A Randomized Crossover Feasibility Study.2013
Comparison between two different neuromuscular electrical stimulation protocols for the treatment of female stress urinary incontinence: a randomized controlled trial.2011
Mild and moderate female stress urinary incontinence treated with transcutaneous acupoint electrical stimulation: a randomized controlled trial.2015
A pilot study on the use of acupuncture or pelvic floor muscle training for mixed urinary incontinence.2016
Cycling Versus Continuous Mode In Neuromodulator Programming: A Crossover, Randomized, Controlled Trial.2017
Long-term results of a clinical trial comparing isolated vaginal stimulation with combined treatment for women with stress incontinence.2014
Short-term Uresta efficacy (SURE) study: a randomized controlled trial of the Uresta continence device.2017
Physical therapy for urinary incontinence in postmenopausal women with osteoporosis or low bone density: a randomized controlled trial.2016
Comparing Resisted Hip Rotation With Pelvic Floor Muscle Training in Women With Stress Urinary Incontinence: A Pilot Study2014
Long-term effects of pelvic floor muscle training with vaginal cone in post-menopausal women with urinary incontinence: a randomized controlled trial.2013
Defeating Urinary Incontinence with Exercise Training: Results of a Pilot Study in Frail Older Women.2017
Observational study on safety and tolerability of duloxetine in the treatment of female stress urinary incontinence in German routine practice.2013
A pilot randomised controlled trial of the pelvic toner device in female stress urinary incontinence.2013
Dynamic lumbopelvic stabilization for treatment of stress urinary incontinence in women: Controlled and randomized clinical trial2017
Prospective Randomized Crossover Trial Comparing Continuous and Cyclic Stimulation in InterStim Therapy.-- Not Found --
Long-term sacral magnetic stimulation for refractory stress urinary incontinence.2014
Individual and group pelvic floor muscle training versus no treatment in female stress urinary incontinence: a randomized controlled pilot study.
Randomized controlled trial of pelvic floor muscle training with or without biofeedback for urinary incontinence.
Percutaneous tibial nerve stimulation versus neurostimulation of SP 6 (Sanyinjiao) in urge incontinence. [Spanish]2013
A pilot randomized control trial to evaluate pelvic floor muscle training for urinary incontinence among gynecologic cancer survivors.2014
Rectal balloon training as an adjunctive method for pelvic floor muscle training in conservative management of stress urinary incontinence: a pilot study.2012
A group-based yoga therapy intervention for urinary incontinence in women: a pilot randomized trial.2014
Pelvic floor muscle exercises utilizing trunk stabilization for treating postpartum urinary incontinence: randomized controlled pilot trial of supervised versus unsupervised training.2012
Effects of Stabilization Exercises Focusing on Pelvic Floor Muscles on Low Back Pain and Urinary Incontinence in Women.2016
Effect the adding of biofeedback to the training of the pelvic floor muscles to treatment of stress urinary incontinence.2012
Efficacy of Electrical Pudendal Nerve Stimulation in Treating Female Stress Incontinence.2016
Telerehabilitation to treat stress urinary incontinence. Pilot study.2015
Effects of surface electrical stimulation in older women with stress urinary incontinence: a randomized controlled pilot study.2012
Effectiveness of continence promotion for older women via community organisations: a cluster randomised trial.2013
Does pelvic floor muscle training abolish symptoms of urinary incontinence? A randomized controlled trial.2015
Multicentric prospective randomized and controlled study assessing effectiveness of intravaginal electrostimulation at home compared to usual care in female patients with urinary incontinence and prior perineal reeducation.2014
Efficacy and safety of oxybutynin chloride topical gel for women with overactive bladder syndrome.2012
Effect of electromyographic biofeedback as an add-on to pelvic floor muscle exercises on neuromuscular outcomes and quality of life in postmenopausal women with stress urinary incontinence: A randomized controlled trial.2017
Effects of magnetic stimulation on urodynamic stress incontinence refractory to pelvic floor muscle training in a randomized sham-controlled study.2017
Impact of pelvic floor muscle training on sexual function of women with urinary incontinence and a comparison of electrical stimulation versus standard treatment (IPSU trial): a randomised controlled trial.2017
Effect of Electroacupuncture on Urinary Leakage Among Women With Stress Urinary Incontinence: A Randomized Clinical Trial.
Comparison of mindfulness-based stress reduction versus yoga on urinary urge incontinence: a randomized pilot study. with 6-month and 1-year follow-up visits.
Randomized controlled trial of pelvic floor muscle training with or without biofeedback for urinary incontinence.2013
A group-based yoga therapy intervention for urinary incontinence in women: a pilot randomized trial.-- Not Found --
Effect of Electroacupuncture on Urinary Leakage Among Women With Stress Urinary Incontinence: A Randomized Clinical Trial.
Development of a pelvic floor muscle strength evaluation device.2015
The efficacy and safety of solifenacin in patients with overactive bladder syndrome.2012
Individual and group pelvic floor muscle training versus no treatment in female stress urinary incontinence: a randomized controlled pilot study.2011
Detection of herpes simplex virus type 1 transcripts during latent infection in mice.1987
Stress urinary incontinence and pelvic floor muscle exercises: effectiveness two different training intensive versus home instruccitions2008

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