Diagnostic Accuracy of Screening Tests and Treatment of Post-Acute Coronary Syndrome (ACS) Depression: A Systematic Review

Project Summary Title and Description

Title
Diagnostic Accuracy of Screening Tests and Treatment of Post-Acute Coronary Syndrome (ACS) Depression: A Systematic Review
Description
Objective: To evaluate (1) the diagnostic accuracy of selected depression screening instruments and strategies versus a validated criterion standard in adult patients within 3 months of an acute coronary syndrome (ACS) event, and (2) the comparative safety and effectiveness of a broad range of pharmacologic and nonpharmacologic treatments for depression in adult patients who have received a criterion-based diagnosis of depression or had clinically important depressive symptoms using a validated depression scale, and who are within 3 months of an ACS event. Data Sources: We searched PubMed®, Embase®, PsycINFO®, CINAHL®, and the Cochrane Database of Systematic Reviews for English-language studies published from January 1, 2003, to April 27, 2017, that evaluated the accuracy of tools for diagnosing depression in patients after ACS or that evaluated interventions for treating post-ACS patients identified with depression. Review Methods: Two investigators individually screened each abstract and full-text article for inclusion; abstracted data; and rated quality, applicability, and strength of evidence. Where appropriate, random-effects models were used to compute summary estimates of effects.
Attribution
N/A
Authors of Report
N/A
Methodology description
We searched MEDLINE® (via PubMed), Embase®, PsycINFO®, CINAHL®, and the Cochrane Database of Systematic Reviews (CDSR), limiting the search to articles published from January 1, 2003, to April 27, 2017. Two investigators screened each abstract and full-text article for inclusion, abstracted the data, and performed quality ratings and evidence grading. Random-effects models were used to compute summary estimates of effects. See the review protocol (https://effectivehealthcare.ahrq.gov/topics/acs-depression/research-protocol/) for full details.
PROSPERO
CRD42016047032
DOI
10.26300/75ew-7r85
Notes
This project was entered retrospectively. All Data Abstraction is available in the attached file: Post-ACS Depression_SRDR File_Final.xlsx
Funding Source
Agency for Healthcare Research and Quality (AHRQ)

Key Questions

1. KQ 1: What is the accuracy of depression screening instruments or screening strategies compared to a validated criterion standard in post-ACS patients?
2. KQ 2: What are the comparative safety and effectiveness of pharmacologic and nonpharmacologic depression treatments in post-ACS patients?

Associated Extraction Forms

Downloadable Data Content

Files
  • XLSX Project Data