Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD): A Systematic Review Update

Project Summary Title and Description

Title
Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD): A Systematic Review Update
Description
This systematic review is an update of a 2013 report that evaluated psychological and pharmacological treatments of adults with posttraumatic stress disorder (PTSD). The purpose of this review is to update the earlier work, expand the range of treatments examined, address earlier uncertainties, identify ways to improve care for PTSD patients, and reduce variation in existing treatment guidelines.
Attribution
N/A
Authors of Report
N/A
Methodology description
We systematically searched, reviewed, and analyzed the scientific evidence gathered to help answer our KQs. We began with a focused MEDLINE® search for eligible interventions using a combination of medical subject headings (MeSH®) and title and abstract keywords, limiting the search to human-only studies (from inception through September 29, 2017). We also searched the Cochrane Library, the Cochrane Clinical Trials Registry, PsycINFO, the Cumulative Index to Nursing and Allied Health Literature, and the Published International Literature on Traumatic Stress database using analogous search terms. These searches included randomized controlled trials (RCTs), controlled clinical trials, and systematic reviews. All titles and abstracts identified via searches were duly reviewed by trained research team members, and the full texts of those included articles were then retrieved and reviewed, and a final determination about inclusion was made. Data from included articles was abstracted, and information included in the report and appendices (see supplemental data files).
PROSPERO
CRD42017075672
DOI
10.26300/1ejy-9v63
Notes
All of the report's study data was entered retrospectively to SRDR via direct file uploading as Word documents. Three of the supplementary files provide data for all KQ 1-4 included studies, one supplementary file provides data on a subset of KQ 1-4 studies, and one file provides data from KQ 4 studies only. Although all studies underwent Risk of Bias (ROB) review, only studies with low and medium ROB were included in the results assessment. For this reason, ROB review data for those studies rated "high" ROB is not provided in the supplemental data files for this project.
Funding Source
This report is based on research conducted by the RTI-UNC Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), and funded by the Patient-Centered Outcomes Research Institute (PCORI).

Key Questions

1. KQ1: What is the comparative effectiveness of different psychological treatments for adults diagnosed with PTSD? KQ1a: How does comparative effectiveness vary by patient characteristics or type of trauma experienced?
2. KQ 2: What is the comparative effectiveness of different pharmacological treatments for adults diagnosed with PTSD? KQ 2a. How does comparative effectiveness vary by patient characteristics or type of trauma experienced?
3. KQ 3: What is the comparative effectiveness of different psychological treatments and pharmacological treatments for adults diagnosed with PTSD? KQ 3a. How does comparative effectiveness vary by patient characteristics or type of trauma experienced?
4. What adverse events (AEs) are associated with treatments for adults diagnosed with PTSD?

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