Systematic reviews on interventions for corneal disease: What is the reliability of the evidence?

Project Summary Title and Description

Title
Systematic reviews on interventions for corneal disease: What is the reliability of the evidence?
Description
Although a number of systematic reviews on corneal disease have been published, the reliability of these reviews remains unclear. We will characterize and appraise the methodological reliability of systematic reviews on interventions for corneal disease. The purpose of our study is to evaluate the current available evidence on interventions for corneal disease, state the strengths and limitations and formulate recommendations for improving future review conduct.
Attribution
N/A
Authors of Report
N/A
Methodology description
N/A
PROSPERO
N/A
DOI
10.26300/jq66-eb95
Notes
N/A
Funding Source
National Eye Institute

Key Questions

1. What is the reliability of systematic reviews on interventions for corneal disease?

Associated Extraction Forms

Associated Studies (each link opens a new tab)

TitleAuthorsYear
Corneal collagen crosslinking: a systematic review.
Effectiveness of subcutaneous immunotherapy for allergic rhinoconjunctivitis and asthma: a systematic review.
Efficacy and safety of rupatadine for allergic rhino-conjunctivitis: a systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis.
Topical cyclosporine in the treatment of allergic conjunctivitis: a meta-analysis.
Conjunctivitis: a systematic review of diagnosis and treatment.
Corneal collagen crosslinking: a systematic review.2014
Effectiveness of subcutaneous immunotherapy for allergic rhinoconjunctivitis and asthma: a systematic review.2014
Efficacy and safety of rupatadine for allergic rhino-conjunctivitis: a systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis.2013
Topical cyclosporine in the treatment of allergic conjunctivitis: a meta-analysis.2013
Conjunctivitis: a systematic review of diagnosis and treatment.2013
Evidence-based review and assessment of botulinum neurotoxin for the treatment of movement disorders.
Descemet stripping endothelial keratoplasty--rapid recovery of visual acuity.
Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review.
Nursing interventions for adult intensive care patients with risk for corneal injury: a systematic review.
The effect of hinge location on corneal sensation and dry eye after LASIK: a systematic review and meta-analysis.
Evidence-based review and assessment of botulinum neurotoxin for the treatment of movement disorders.2013
Descemet stripping endothelial keratoplasty--rapid recovery of visual acuity.2013
Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review.2013
Nursing interventions for adult intensive care patients with risk for corneal injury: a systematic review.2013
The effect of hinge location on corneal sensation and dry eye after LASIK: a systematic review and meta-analysis.2013
Fluoroquinolones or fortified antibiotics for treating bacterial keratitis: systematic review and meta-analysis of comparative studies.
Comparison of pterygium recurrence rates after limbal conjunctival autograft transplantation and other techniques: meta-analysis.
Corneal collagen cross-linking for nonectatic disorders: a systematic review.
Posology, efficacy, and safety of epidermal growth factor eye drops in 305 patients: logistic regression and group-wise odds of published data.
Alcaftadine for the prevention of itching associated with allergic conjunctivitis.
Fluoroquinolones or fortified antibiotics for treating bacterial keratitis: systematic review and meta-analysis of comparative studies.2012
Comparison of pterygium recurrence rates after limbal conjunctival autograft transplantation and other techniques: meta-analysis.2012
Corneal collagen cross-linking for nonectatic disorders: a systematic review.2012
Posology, efficacy, and safety of epidermal growth factor eye drops in 305 patients: logistic regression and group-wise odds of published data.2012
Alcaftadine for the prevention of itching associated with allergic conjunctivitis.-- Not Found --
Critical appraisal of loteprednol ointment, gel, and suspension in the treatment of postoperative inflammation and pain following ocular and corneal transplant surgery.
Bevacizumab in the treatment of pterygium: a meta-analysis.
Anterior segment uses of bevacizumab.
Interventions for recurrent corneal erosions.
Antibiotics versus placebo for acute bacterial conjunctivitis.
Critical appraisal of loteprednol ointment, gel, and suspension in the treatment of postoperative inflammation and pain following ocular and corneal transplant surgery.2014
Bevacizumab in the treatment of pterygium: a meta-analysis.2014
Anterior segment uses of bevacizumab.2012
Interventions for recurrent corneal erosions.
Antibiotics versus placebo for acute bacterial conjunctivitis.
Endothelial keratoplasty versus penetrating keratoplasty for Fuchs endothelial dystrophy.
Interventions for chronic blepharitis.
Topical cyclosporine for atopic keratoconjunctivitis.
Interventions for Mooren's ulcer.
Corneal cross linking and infectious keratitis: a systematic review with a meta-analysis of reported cases.
Endothelial keratoplasty versus penetrating keratoplasty for Fuchs endothelial dystrophy.2014
Interventions for chronic blepharitis.
Topical cyclosporine for atopic keratoconjunctivitis.2012
Interventions for Mooren's ulcer.2014
Corneal cross linking and infectious keratitis: a systematic review with a meta-analysis of reported cases.2013
Efficacy of treatment for pterygium by autologous conjunctival transplantation and mitomycin C.
Comparison of conjunctival autograft transplantation and amniotic membrane transplantation for pterygium: a meta-analysis.
Mast cell stabilization and anti-histamine effects of olopatadine ophthalmic solution: a review of pre-clinical and clinical research.
Evidence-based emergency medicine. Update: do ophthalmic nonsteroidal anti-inflammatory drugs reduce the pain associated with simple corneal abrasion without delaying healing?
Topical treatments for seasonal allergic conjunctivitis: systematic review and meta-analysis of efficacy and effectiveness.
Efficacy of treatment for pterygium by autologous conjunctival transplantation and mitomycin C.2012
Comparison of conjunctival autograft transplantation and amniotic membrane transplantation for pterygium: a meta-analysis.2012
Mast cell stabilization and anti-histamine effects of olopatadine ophthalmic solution: a review of pre-clinical and clinical research.
Evidence-based emergency medicine. Update: do ophthalmic nonsteroidal anti-inflammatory drugs reduce the pain associated with simple corneal abrasion without delaying healing?2003
Topical treatments for seasonal allergic conjunctivitis: systematic review and meta-analysis of efficacy and effectiveness.2004
Topical nonsteroidal anti-inflammatory drugs for corneal abrasions: meta-analysis of randomized trials.
Should we patch corneal abrasions? A meta-analysis.
Patching for corneal abrasion.
Optic and otic side effects of molecular targeted therapies.
The role of benzalkonium chloride in the occurrence of punctate keratitis: a meta-analysis of randomized, controlled clinical trials.
Topical nonsteroidal anti-inflammatory drugs for corneal abrasions: meta-analysis of randomized trials.2005
Should we patch corneal abrasions? A meta-analysis.1998
Patching for corneal abrasion.2016
Optic and otic side effects of molecular targeted therapies.2014
The role of benzalkonium chloride in the occurrence of punctate keratitis: a meta-analysis of randomized, controlled clinical trials.2010
Corneal refractive surgery and phakic intraocular lens for treatment of amblyopia caused by high myopia or anisometropia in children.
Characteristics of corneal ectasia after LASIK for myopia.
Medical interventions for fungal keratitis.
Surgical management for postkeratoplasty glaucoma: a meta-analysis.
Systematic review and meta-analysis on transplantation of ex vivo cultivated limbal epithelial stem cell on amniotic membrane in limbal stem cell deficiency.
Corneal refractive surgery and phakic intraocular lens for treatment of amblyopia caused by high myopia or anisometropia in children.2014
Characteristics of corneal ectasia after LASIK for myopia.2004
Medical interventions for fungal keratitis.
Surgical management for postkeratoplasty glaucoma: a meta-analysis.2014
Systematic review and meta-analysis on transplantation of ex vivo cultivated limbal epithelial stem cell on amniotic membrane in limbal stem cell deficiency.2015
Immunosuppressants for the prophylaxis of corneal graft rejection after penetrating keratoplasty.
Artificial corneas versus donor corneas for repeat corneal transplants.
Medical interventions for acanthamoeba keratitis.
Topical corticosteroids as adjunctive therapy for bacterial keratitis.
Topical antibiotics for the management of bacterial keratitis: an evidence-based review of high quality randomised controlled trials.
Immunosuppressants for the prophylaxis of corneal graft rejection after penetrating keratoplasty.2015
Artificial corneas versus donor corneas for repeat corneal transplants.2014
Medical interventions for acanthamoeba keratitis.2015
Topical corticosteroids as adjunctive therapy for bacterial keratitis.2014
Topical antibiotics for the management of bacterial keratitis: an evidence-based review of high quality randomised controlled trials.2014
Corneal collagen cross-linking for treating keratoconus.
A systematic review and meta-analysis to compare the efficacy of acyclovir 3% ophthalmic ointment to idoxuridine in curing herpetic keratitis by Day 7 of treatment.
Infectious endophthalmitis in Boston keratoprosthesis: incidence and prevention.
Conjunctival autograft for pterygium.
Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.
Corneal collagen cross-linking for treating keratoconus.2015
A systematic review and meta-analysis to compare the efficacy of acyclovir 3% ophthalmic ointment to idoxuridine in curing herpetic keratitis by Day 7 of treatment.2015
Infectious endophthalmitis in Boston keratoprosthesis: incidence and prevention.2014
Conjunctival autograft for pterygium.2016
Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.2015
Evaluation of the effectiveness of the common drugs for herpes simplex keratitis by using the evidence-based medicine method
Evaluation of the effectiveness of the common drugs for herpes simplex keratitis by using the evidence-based medicine method2008
Meta-analysis of clinical effectiveness of the treatment of limbal autograft stem cells transplantation with the use of mitomycin-C for pterygium
Meta-analysis of clinical effectiveness of the treatment of limbal autograft stem cells transplantation with the use of mitomycin-C for pterygium2013
Meta analysis of deep lamellar keratoplasty and penetrating keratoplasty for keratoconus
Meta analysis of deep lamellar keratoplasty and penetrating keratoplasty for keratoconus2012
Comparison among different surgical treatments for recurrent pterygium: a systematic review
Comparison among different surgical treatments for recurrent pterygium: a systematic review2012
Corneal neovascularization and treatment
Corneal neovascularization and treatment2010
What type of eye drops should be given to a toddler with conjunctivitis?
Sublingual immunotherapy in asthma and rhinoconjunctivitis; systematic review of paediatric literature.
Bacterial conjunctivitis.
Treatment of viral conjunctivitis with antiviral drugs.
Should intranasal corticosteroids be used for the treatment of ocular symptoms of allergic rhinoconjunctivitis? A review of their efficacy and safety profile.
Acute infective conjunctivitis in primary care: who needs antibiotics? An individual patient data meta-analysis.
Sublingual immunotherapy for treating allergic conjunctivitis.
Immunotherapy in children and adolescents with allergic rhinoconjunctivitis: a systematic review.
Systematic review and meta-analysis of randomised clinical trials on topical treatments for vernal keratoconjunctivitis.
Topical non-steroidal anti-inflammatory drugs in allergic conjunctivitis: meta-analysis of randomized trial data.
Management strategies for acute infective conjunctivitis in primary care: a systematic review.
Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis.
A meta-analysis of sublingual allergen immunotherapy and pharmacotherapy in pollen-induced seasonal allergic rhinoconjunctivitis.
What type of eye drops should be given to a toddler with conjunctivitis?2003
Sublingual immunotherapy in asthma and rhinoconjunctivitis; systematic review of paediatric literature.2004
Bacterial conjunctivitis.2012
Treatment of viral conjunctivitis with antiviral drugs.2011
Should intranasal corticosteroids be used for the treatment of ocular symptoms of allergic rhinoconjunctivitis? A review of their efficacy and safety profile.2012
Acute infective conjunctivitis in primary care: who needs antibiotics? An individual patient data meta-analysis.2011
Sublingual immunotherapy for treating allergic conjunctivitis.
Immunotherapy in children and adolescents with allergic rhinoconjunctivitis: a systematic review.2008
Systematic review and meta-analysis of randomised clinical trials on topical treatments for vernal keratoconjunctivitis.2007
Topical non-steroidal anti-inflammatory drugs in allergic conjunctivitis: meta-analysis of randomized trial data.-- Not Found --
Management strategies for acute infective conjunctivitis in primary care: a systematic review.2007
Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis.2015
A meta-analysis of sublingual allergen immunotherapy and pharmacotherapy in pollen-induced seasonal allergic rhinoconjunctivitis.2014
Clinical trials in allergic conjunctivits: a systematic review.
A meta-analysis of the efficacy of ocular prophylactic agents used for the prevention of gonococcal and chlamydial ophthalmia neonatorum.
Practical approach to diagnosis and treatment of ocular allergy: a 1-year systematic review.
Clinical trials in allergic conjunctivits: a systematic review.2011
A meta-analysis of the efficacy of ocular prophylactic agents used for the prevention of gonococcal and chlamydial ophthalmia neonatorum.
Practical approach to diagnosis and treatment of ocular allergy: a 1-year systematic review.2007
Osteo-odonto keratoprosthesis: systematic review of surgical outcomes and complication rates.
Review: keratoconus in Asia.
Intrastromal corneal ring implants for corneal thinning disorders: an evidence-based analysis.
Evidence-based treatment of herpes simplex virus keratitis: a systematic review.
Descemet's stripping endothelial keratoplasty: safety and outcomes: a report by the American Academy of Ophthalmology.
A systematic review of Ferrara's ring in the treatment of keratoconus.
Boston keratoprosthesis - Clinical outcomes with wider geographic use and expanding indications - A systematic review.
A year of cornea in review: 2013.
Deep Anterior Lamellar Keratoplasty Versus Penetrating Keratoplasty: A Meta-Analysis of Randomized Controlled Trials.
Corneal collagen cross-linking in keratoconus: a systematic review and meta-analysis.
Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis.
Deep anterior lamellar keratoplasty versus penetrating keratoplasty for treating keratoconus.
Efficacy and safety of deep anterior lamellar keratoplasty vs. penetrating keratoplasty for keratoconus: a meta-analysis.
Safety and efficacy of epithelium removal and transepithelial corneal collagen crosslinking for keratoconus.
Moisture chamber versus lubrication for corneal protection in critically ill patients: a meta-analysis.
Reshaping procedures for the surgical management of corneal ectasia.
Osteo-odonto keratoprosthesis: systematic review of surgical outcomes and complication rates.2012
Review: keratoconus in Asia.2012
Intrastromal corneal ring implants for corneal thinning disorders: an evidence-based analysis.2009
Evidence-based treatment of herpes simplex virus keratitis: a systematic review.2007
Descemet's stripping endothelial keratoplasty: safety and outcomes: a report by the American Academy of Ophthalmology.2009
A systematic review of Ferrara's ring in the treatment of keratoconus.2008
Boston keratoprosthesis - Clinical outcomes with wider geographic use and expanding indications - A systematic review.-- Not Found --
A year of cornea in review: 2013.-- Not Found --
Deep Anterior Lamellar Keratoplasty Versus Penetrating Keratoplasty: A Meta-Analysis of Randomized Controlled Trials.2016
Corneal collagen cross-linking in keratoconus: a systematic review and meta-analysis.2014
Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis.2014
Deep anterior lamellar keratoplasty versus penetrating keratoplasty for treating keratoconus.2014
Efficacy and safety of deep anterior lamellar keratoplasty vs. penetrating keratoplasty for keratoconus: a meta-analysis.2015
Safety and efficacy of epithelium removal and transepithelial corneal collagen crosslinking for keratoconus.2015
Moisture chamber versus lubrication for corneal protection in critically ill patients: a meta-analysis.2014
Reshaping procedures for the surgical management of corneal ectasia.2015
Olopatadine for the treatment of allergic conjunctivitis: a review of the clinical efficacy, safety, and cost-effectiveness
Olopatadine for the treatment of allergic conjunctivitis: a review of the clinical efficacy, safety, and cost-effectiveness2012
Allergen-specific immunotherapy for the treatment of allergic rhinoconjunctivitis and/or asthma: comparative effectiveness review
Allergen-specific immunotherapy for the treatment of allergic rhinoconjunctivitis and/or asthma: comparative effectiveness review 2013
Efficacy of intranasal corticosteroids for the ocular symptoms of allergic rhinitis: A systematic review.
Efficacy of intranasal corticosteroids for the ocular symptoms of allergic rhinitis: A systematic review.-- Not Found --
Interventions for rosacea.
Indecision about corticosteroids for bacterial keratitis: an evidence-based update.
Ocular Manifestations and Therapeutic Options in Patients with Familial Amyloid Polyneuropathy: A Systematic Review.
Impact of mometasone furoate nasal spray on individual ocular symptoms of allergic rhinitis: a meta-analysis.
Leukotriene receptor antagonists in allergic eye disease: a systematic review and meta-analysis.
Topical treatments for blepharokeratoconjunctivitis in children.
Systemic treatment for blepharokeratoconjunctivitis in children.
Are intranasal corticosteroids all equally consistent in managing ocular symptoms of seasonal allergic rhinitis?
Efficacy of fluticasone furoate nasal spray vs. placebo for the treatment of ocular and nasal symptoms of allergic rhinitis: a systematic review.
Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions.
Acupuncture for acute hordeolum.
Non-surgical interventions for acute internal hordeolum.
The role of radiotherapy in the treatment of pterygium: a review of the literature including more than 6000 treated lesions.
Ocular herpes simplex.
Meta-analysis on the recurrence rates after bare sclera resection with and without mitomycin C use and conjunctival autograft placement in surgery for primary pterygium.
Interventions for rosacea.2015
Indecision about corticosteroids for bacterial keratitis: an evidence-based update.2002
Ocular Manifestations and Therapeutic Options in Patients with Familial Amyloid Polyneuropathy: A Systematic Review.2015
Impact of mometasone furoate nasal spray on individual ocular symptoms of allergic rhinitis: a meta-analysis.2011
Leukotriene receptor antagonists in allergic eye disease: a systematic review and meta-analysis.2013
Topical treatments for blepharokeratoconjunctivitis in children.
Systemic treatment for blepharokeratoconjunctivitis in children.2016
Are intranasal corticosteroids all equally consistent in managing ocular symptoms of seasonal allergic rhinitis?2009
Efficacy of fluticasone furoate nasal spray vs. placebo for the treatment of ocular and nasal symptoms of allergic rhinitis: a systematic review.2011
Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions.2017
Acupuncture for acute hordeolum.
Non-surgical interventions for acute internal hordeolum.2017
The role of radiotherapy in the treatment of pterygium: a review of the literature including more than 6000 treated lesions.2011
Ocular herpes simplex.2008
Meta-analysis on the recurrence rates after bare sclera resection with and without mitomycin C use and conjunctival autograft placement in surgery for primary pterygium.1998
Meta-analysis of fibrin glue for attaching conjunctival autografts in pterygium surgery.
Meta-analysis of fibrin glue for attaching conjunctival autografts in pterygium surgery.2011
Intrastromal corneal implants for ectatic corneal disorders.
Intrastromal corneal implants for ectatic corneal disorders.2015
A review on recent advances in dry eye: Pathogenesis and management.
A review on recent advances in dry eye: Pathogenesis and management.2011
A review and meta-analysis of corneal cross-linking for post-laser vision correction ectasia
A review and meta-analysis of corneal cross-linking for post-laser vision correction ectasia2017
Efficacy of Topical Analgesics in Pain Control for Corneal Abrasions: A Systematic Review.
Efficacy of Topical Analgesics in Pain Control for Corneal Abrasions: A Systematic Review.2017
Efficacy of Carboxymethylcellulose and Hyaluronate in Dry Eye Disease: A Systematic Review and Meta-Analysis.
Efficacy of Carboxymethylcellulose and Hyaluronate in Dry Eye Disease: A Systematic Review and Meta-Analysis.2017
Efficacy of nutritional supplementation with omega-3 and omega-6 fatty acids in dry eye syndrome: a systematic review of randomized clinical trials.
Cross-linking in children with keratoconus: a systematic review and meta-analysis.
Outcome of Keratoconus Management: Review of the Past 20 Years' Contemporary Treatment Modalities.
The safety and efficacy of Diphoterine for ocular and cutaneous burns in humans.2017
Corneal Collagen Cross-Linking for Keratoconus: Systematic Review.
Systematic review comparing penetrating keratoplasty and deep anterior lamellar keratoplasty for management of keratoconus.
Adjunctive Therapies for Bacterial Keratitis.
Corneal Collagen Cross-Linking for Infectious Keratitis: A Systematic Review and Meta-Analysis.
Efficacy of Corneal Collagen Cross-Linking for the Treatment of Keratoconus: A Systematic Review and Meta-Analysis.
Topical Olopatadine in the Treatment of Allergic Conjunctivitis: A Systematic Review and Meta-analysis.
Corneal Cross-Linking for Pediatric Keratoconus: Long-Term Results.
Systemic Immunosuppression in High-Risk Penetrating Keratoplasty: A Systematic Review.
Incision and Curettage Versus Steroid Injection for the Treatment of Chalazia: A Meta-Analysis.
Boston Type 1 Keratoprosthesis versus Repeat Donor Keratoplasty for Corneal Graft Failure: A Systematic Review and Meta-analysis.
Infectious Keratitis Following Corneal Crosslinking: A Systematic Review of Reported Cases: Management, Visual Outcome, and Treatment Proposed.
Current and Future Applications of Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL): An Overview of the Different Treatments Proposed.
Efficacy of nutritional supplementation with omega-3 and omega-6 fatty acids in dry eye syndrome: a systematic review of randomized clinical trials.2017
Cross-linking in children with keratoconus: a systematic review and meta-analysis.2017
Outcome of Keratoconus Management: Review of the Past 20 Years' Contemporary Treatment Modalities.2017
The safety and efficacy of Diphoterine for ocular and cutaneous burns in humans.2017
Corneal Collagen Cross-Linking for Keratoconus: Systematic Review.2017
Systematic review comparing penetrating keratoplasty and deep anterior lamellar keratoplasty for management of keratoconus.2017
Adjunctive Therapies for Bacterial Keratitis.-- Not Found --
Corneal Collagen Cross-Linking for Infectious Keratitis: A Systematic Review and Meta-Analysis.2016
Efficacy of Corneal Collagen Cross-Linking for the Treatment of Keratoconus: A Systematic Review and Meta-Analysis.2016
Topical Olopatadine in the Treatment of Allergic Conjunctivitis: A Systematic Review and Meta-analysis.2017
Corneal Cross-Linking for Pediatric Keratoconus: Long-Term Results.2016
Systemic Immunosuppression in High-Risk Penetrating Keratoplasty: A Systematic Review.2016
Incision and Curettage Versus Steroid Injection for the Treatment of Chalazia: A Meta-Analysis.-- Not Found --
Boston Type 1 Keratoprosthesis versus Repeat Donor Keratoplasty for Corneal Graft Failure: A Systematic Review and Meta-analysis.2016
Infectious Keratitis Following Corneal Crosslinking: A Systematic Review of Reported Cases: Management, Visual Outcome, and Treatment Proposed.2016
Current and Future Applications of Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL): An Overview of the Different Treatments Proposed.2016

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