Interventions for Substance Use Disorders in Adolescents: A Systematic Review

Project Summary Title and Description

Interventions for Substance Use Disorders in Adolescents: A Systematic Review
The review aims to inform health care providers, policymakers, and a clinical practice guideline update from the American Academy of Child and Adolescent Psychiatry (AACAP) about the currently available evidence on interventions for adolescents to reduce or cease substance use. The review addresses both behavioral and pharmacological interventions used for adolescents or young adults with problematic substance use or a diagnosis of a substance use disorder (SUD), excluding tobacco.
Authors of Report
Methodology description
We conducted literature searches in MEDLINE, the Cochrane CENTRAL Trials Registry, Embase, CINAHL, and PsycINFO databases (all from inception) to identify primary studies meeting our criteria through April 11, 2019. As a part of an independent methods project, an interim search of MEDLINE was undertaken using text mining tools on October 30, 2018. A separate search for SRs of interventions for alcohol disorders/problematic alcohol use in the college setting was conducted in MEDLINE, Cochrane Database of Systematic Reviews, and Epistemonikos also through April 11, 2019; after discussion with the Technical Expert Panel (TEP), it was decided to restrict the review of this topic to existing SRs because the literature is vast and has been extensively reviewed. The literature search yielded 33,272 citations. We found 118 randomized controlled trials that evaluated treatment of adolescents or young adults with problematic substance use or substance use disorders.
Included in the downloadable content for this project, is the Excel file, "baselines_and_interventions.xlsx", which contains two sheets of detailed extractions: "baselines" and "interventions". All other extracted data was entered prospectively into SRDR.
Funding Source
HHSA 290-2015-00002-I

Key Questions

1. Evidence map

Associated Extraction Forms

Associated Studies (each link opens a new tab)

Juvenile drug court: enhancing outcomes by integrating evidence-based treatments.2006
Sequenced versus coordinated treatment for adolescents with comorbid depressive and substance use disorders.2014
Randomized controlled trial of motivational enhancement therapy with nontreatment-seeking adolescent cannabis users: a further test of the teen marijuana check-up.2011
Short- to Midterm Effectiveness of a Brief Motivational Intervention to Reduce Alcohol Use and Related Problems for Alcohol Intoxicated Children and Adolescents in Pediatric Emergency Departments: A Randomized Controlled Trial.2017
Screening and brief intervention to reduce marijuana use among youth and young adults in a pediatric emergency department.
A brief motivational interview in a pediatric emergency department, plus 10-day telephone follow-up, increases attempts to quit drinking among youth and young adults who screen positive for problematic drinking.2010
Cultural accommodation of group substance abuse treatment for Latino adolescents: Results of an RCT.2015
Motivational Interviewing to Reduce Substance Use in Adolescents with Psychiatric Comorbidity.2015
Brief Motivational Intervention for Underage Young Adult Drinkers: Results from a Randomized Clinical Trial.2018
Double-blind placebo-controlled trial of fluoxetine in adolescents with comorbid major depression and an alcohol use disorder.2009
Alcohol Interventions Among Underage Drinkers in the ED: A Randomized Controlled Trial.2015
Brief motivational interviewing for teens at risk of substance use consequences: a randomized pilot study in a primary care clinic.2008
A randomized clinical trial of family therapy in juvenile drug court.2015
A randomized controlled trial of a brief motivational enhancement for non-treatment-seeking adolescent cannabis users.
Treatment of co-occurring substance abuse and suicidality among adolescents: a randomized trial.
Memantine improves buprenorphine/naloxone treatment for opioid dependent young adults.2015
A pilot randomized clinical trial testing integrated 12-Step facilitation (iTSF) treatment for adolescent substance use disorder.2017
Comparison of pharmacological treatments for opioid-dependent adolescents: a randomized controlled trial.2005
Seeking safety therapy for adolescent girls with PTSD and substance use disorder: a randomized controlled trial.2006
Comparison of disulfiram and placebo in treatment of alcohol dependence of adolescents.2003
Reduction of alcohol drinking in young adults by naltrexone: a double-blind, placebo-controlled, randomized clinical trial of efficacy and safety.2015
Cognitive behavioral therapy-based brief intervention for volatile substance misusers during adolescence: a follow-up study.2011
The short-term safety and efficacy of fluoxetine in depressed adolescents with alcohol and cannabis use disorders: a pilot randomized placebo-controlled trial.2009
Preliminary outcomes from the assertive continuing care experiment for adolescents discharged from residential treatment.2002
Adolescent outpatient treatment and continuing care: main findings from a randomized clinical trial.2010
A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents.2012
An independent replication of the Adolescent-Community Reinforcement Approach with justice-involved youth.2016
Randomized Trial of Family Therapy Versus Nonfamily Treatment for Adolescent Behavior Problems in Usual Care.2015
Efficacy of outpatient aftercare for adolescents with alcohol use disorders: a randomized controlled study.2008
Brief motivational intervention with homeless adolescents: evaluating effects on substance use and service utilization.2007
Comparing culturally accommodated versus standard group CBT for Latino adolescents with substance use disorders: a pilot study.2012
Integrated family and cognitive-behavioral therapy for adolescent substance abusers: a stage I efficacy study.2003
First Evaluation of a Contingency Management Intervention Addressing Adolescent Substance Use and Sexual Risk Behaviors: Risk Reduction Therapy for Adolescents.2017
Treating adolescent drug abuse: a randomized trial comparing multidimensional family therapy and cognitive behavior therapy.2008
Multidimensional Family Therapy as a community-based alternative to residential treatment for adolescents with substance use and co-occurring mental health disorders.2018
Double-blind fluoxetine trial in comorbid MDD-CUD youth and young adults.2010
A randomized controlled trial of buprenorphine taper duration among opioid-dependent adolescents and young adults.2016
An evaluation of a brief motivational intervention among young ecstasy and cocaine users: no effect on substance and alcohol use outcomes.
The adolescent cannabis check-up: randomized trial of a brief intervention for young cannabis users.
Peer Network Counseling with Urban Adolescents: A Randomized Controlled Trial with Moderate Substance Users.
The efficacy of single-session motivational interviewing in reducing drug consumption and perceptions of drug-related risk and harm among young people: results from a multi-site cluster randomized trial.
Randomized controlled trial of motivational interviewing compared with drug information and advice for early intervention among young cannabis users.
Effects of naltrexone on adolescent alcohol cue reactivity and sensitivity: an initial randomized trial.2014
Topiramate and motivational enhancement therapy for cannabis use among youth: a randomized placebo-controlled pilot study.2017
A randomized controlled trial of an online relapse prevention program for adolescents in substance abuse treatment2017
Multidimensional family therapy for adolescent drug abuse: results of a randomized clinical trial.2001
Brief intervention for harm reduction with alcohol-positive older adolescents in a hospital emergency department.1999
Multidimensional family therapy lowers the rate of cannabis dependence in adolescents: a randomised controlled trial in Western European outpatient settings.2013
Preliminary results for an adaptive family treatment for drug abuse in Hispanic youth.2011
Brief intervention for drug-abusing adolescents in a school setting: outcomes and mediating factors.2012
Ecologically based family therapy outcome with substance abusing runaway adolescents.2005
Treatment outcome for street-living, homeless youth.
Brief strategic family therapy versus treatment as usual: results of a multisite randomized trial for substance using adolescents.2011
A randomized clinical trial of a brief motivational intervention for alcohol-positive adolescents treated in an emergency department.2004
Enhancing the effectiveness of juvenile drug courts by integrating evidence-based practices.2012
Motivational Interviewing With and Without Normative Feedback for Adolescents With Substance Use Problems: A Preliminary Study.2015
The efficacy of two adolescent substance abuse treatments and the impact of comorbid depression: results of a small randomized controlled trial.2015
Brief intervention for students with methamphetamine use disorders: a randomized controlled trial.-- Not Found --
Abstinence based incentives plus parent training for adolescent alcohol and other substance misuse.2017
Comparative efficacy of family and group treatment for adolescent substance abuse.2006
Motivational enhancement therapy for adolescent marijuana users: a preliminary randomized controlled trial.2006
Intervention with substance-abusing runaway adolescents and their families: results of a randomized clinical trial.
Effectiveness of a brief-intervention and continuity of care in enhancing attendance for treatment by adolescent substance users.2004
Comparison of family therapy outcome with alcohol-abusing, runaway adolescents.2009
Clinic- and home-based contingency management plus parent training for adolescent cannabis use disorders.2015
A randomized controlled trial of guided self-change with minority adolescents.2014
A randomized trial of contingency management for adolescent marijuana abuse and dependence.
A randomized clinical trial of a targeted intervention to moderate alcohol use and alcohol-related problems in at-risk adolescents.2007
A randomized controlled trial of fluoxetine and cognitive behavioral therapy in adolescents with major depression, behavior problems, and substance use disorders.2007
Augmenting brief interventions for adolescent marijuana users: The impact of motivational check-ins.2016
Motivational interviewing to reduce substance-related consequences: effects for incarcerated adolescents with depressed mood.2011
Short-term effects of a brief motivational intervention to reduce alcohol and drug risk among homeless adolescents.2006
Psychotherapies for adolescent substance abusers: a pilot study.1998
The efficacy of structural ecosystems therapy with drug-abusing/dependent African American and Hispanic American adolescents.2008
Treatment outcomes for adolescent substance abuse at 4- and 7-month assessments.2001
Double-blind and placebo-controlled study of lithium for adolescent bipolar disorders with secondary substance dependency.1998
Cognitive-behavioral coping skills and psychoeducation therapies for adolescent substance abuse.2002
RCT of a promising vocational/employment program for high-risk juvenile offenders.2014
Community partnership to affect substance abuse among Native American adolescents.2012
Family-Based HIV and Sexually Transmitted Infection Risk Reduction for Drug-Involved Young Offenders: 42-Month Outcomes.2016
Eliminating (almost) treatment dropout of substance abusing or dependent delinquents through home-based multisystemic therapy.1996
Assessment of change in scores on personal control orientation and use of drugs and alcohol of adolescents who participate in a cognitively oriented pretreatment intervention.1994
Brief intervention for drug-abusing adolescents in a school setting.2007
Comparison of cyanamide and placebo in the treatment of alcohol dependence of adolescents.-- Not Found --
Effectiveness of a web-based brief alcohol intervention and added value of normative feedback in reducing underage drinking: a randomized controlled trial.2010
A comparison of three interventions for homeless youth evidencing substance use disorders: results of a randomized clinical trial.2015
A controlled evaluation and description of individual-cognitive problem solving and family-behavior therapies in dually-diagnosed conduct-disordered and substance-dependent youth2001
Consejo breve para adolescentes escolares que abusan del alcohol. = School-based brief counseling for teenage drinkers2008
Randomized, controlled trial of atomoxetine for attention-deficit/hyperactivity disorder in adolescents with substance use disorder.2010
Individual and family motivational interventions for alcohol-positive adolescents treated in an emergency department: results of a randomized clinical trial.2011
A randomized controlled trial of pemoline for attention-deficit/hyperactivity disorder in substance-abusing adolescents.2004
Parent and Adolescent Motivational Enhancement Intervention for Substance-Using, Truant Adolescents: A Pilot Randomized Trial.2017
An open randomized trial comparing disulfiram and naltrexone in adolescents with alcohol dependence2008
Extended vs short-term buprenorphine-naloxone for treatment of opioid-addicted youth: a randomized trial.2008
Early intervention for adolescent substance abuse: pretreatment to posttreatment outcomes of a randomized clinical trial comparing multidimensional family therapy and peer group treatment.2004
Randomized controlled trial of osmotic-release methylphenidate with cognitive-behavioral therapy in adolescents with attention-deficit/hyperactivity disorder and substance use disorders.2011
Contingency management in community programs treating adolescent substance abuse: a feasibility study.2012
Comparison of naltrexone and placebo in treatment of alcohol dependence of adolescents2003
Youth drug abuse treatment: a controlled outcome study1994
A comparative study using Disulfiram and Naltrexone in alcohol-dependent adolescents
Treating adolescent drug abuse: a comparison of family systems therapy, group therapy, and family drug education
Efficacy and Tolerability of Topiramate in Treatment of Bipolar Mania and Alcohol Use in Adolescents and Young Adults2017
Efficacy Study of Quetiapine Plus Topiramate for Reducing Cannabis Consumption and Bipolar Mania
A Controlled Study of Inpatient vs. Outpatient Treatment of Delinquent Drug Abusing Adolescents: One Year Results1982
Family therapy vs parent groups: effects on adolescent drug abusers1989
Moderators of outcome in a web-based substance use intervention for adolescents2015
Screening and brief intervention with adolescents with risky alcohol use in school-based health centers: A randomized clinical trial of the Check Yourself tool.2019
Brief motivational interviewing intervention to reduce alcohol and marijuana use for at-risk adolescents in primary care.
Substance use and social stability of homeless youth: A comparison of three interventions.2018
A pilot randomized controlled trial of a technology-based substance use intervention for youth exiting foster care2018
A randomized controlled trial of a group motivational interviewing intervention for adolescents with a first time alcohol or drug offense.-- Not Found --
A randomized trial of Volunteer Recovery Support for Adolescents (VRSA) following residential treatment discharge.2019
Brief alcohol intervention for risky drinking in young people aged 14–15 years in secondary schools: the SIPS JR-HIGH RCT2019
Impact of Brief Intervention Services on Drug Using Truant Youth Arrest Charges over Time.2014
Outcomes of a family-based HIV prevention intervention for substance using juvenile offenders.2017
The Cannabis Youth Treatment (CYT) Study: main findings from two randomized trials.
The Cannabis Youth Treatment (CYT) Study: main findings from two randomized trials.2004
The effectiveness of a web-based brief alcohol intervention in reducing heavy drinking among adolescents aged 15-20 years with a low educational background: a two-arm parallel group cluster randomized controlled trial.

Downloadable Data Content

  • XLSX Project Data