Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacological Interventions

Project Summary Title and Description

Title
Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacological Interventions
Description
A systematic review to assess the efficacy and comparative effectiveness of pharmacological interventions for pregnant and postpartum women with psychiatric disorders.
Attribution
N/A
Authors of Report
N/A
Methodology description
Systematic review
PROSPERO
CRD42019124057
DOI
N/A
Notes
The data was entered retrospectively by uploading Excel worksheets. Uploaded data includes risk of bias assessments, study characteristics, and outcome data (benefits and harms).
Funding Source
AHRQ

Key Questions

1. Among pregnant and postpartum women, what is the effectiveness of pharmacologic interventions on maternal outcomes 1a. Among those with a new or preexisting anxiety disorder? 1b. Among those with a new or preexisting depressive disorder? 1c. Among those with a new or preexisting bipolar disorder? 1d. Among those with new or preexisting schizophrenia?
2. Among pregnant and postpartum women, what is the comparative effectiveness of pharmacologic interventions on maternal outcomes 2a. Among those with a new or preexisting anxiety disorder? 2b. Among those with a new or preexisting depressive disorder? 2c. Among those with a new or preexisting bipolar disorder? 2d. Among those with new or preexisting schizophrenia?
3. Among reproductive-aged women with any mental health disorder, what are the maternal and fetal harms associated with pharmacologic interventions for a mental health disorder during preconception, pregnancy, and postpartum?
4. Among reproductive-aged women with any mental health disorder, what are the comparative maternal and fetal harms of pharmacologic interventions for a mental health disorder during preconception, pregnancy, and postpartum?

Associated Extraction Forms

Associated Studies (each link opens a new tab)

TitleAuthorsYear
A placebo controlled treatment trial of sertraline and interpersonal psychotherapy for postpartum depression.2019
The Relationship Between Pregnancy Exposure to Antidepressant and Atypical Antipsychotic Medications and Placental Weight and Birth Weight Ratio: A Retrospective Cohort Study.2018
Neonatal outcomes in pregnant women with untreated and treated panic disorder.2018
Alterations in Resting-State Networks Following In Utero Selective Serotonin Reuptake Inhibitor Exposure in the Neonatal Brain.2019
Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials.
The use of antidepressant drugs in pregnant women with epilepsy: A study from the Australian Pregnancy Register.2018
Risk of Major Malformations in Infants Following First-Trimester Exposure to Quetiapine.2018
Reproductive Safety of Second-Generation Antipsychotics: Current Data From the Massachusetts General Hospital National Pregnancy Registry for Atypical Antipsychotics.
Major depressive disorder during pregnancy: Psychiatric medications have minimal effects on the fetus and infant yet development is compromised.2018
Comparison of two different treatments in depressed pregnant women: fetal growth characteristics and neonatal outcomes.2018
Obstetrical and neonatal outcomes after benzodiazepine exposure during pregnancy: Results from a prospective registry of women with psychiatric disorders.-- Not Found --
Aripiprazole and pregnancy: A retrospective, multicentre study.2018
Antidepressants and recurrence of depression in the postpartum period.2018
Self-reported perinatal depressive symptoms and postnatal symptom severity after treatment with antidepressants in pregnancy: a cross-sectional study across 12 European countries using the Edinburgh Postnatal Depression Scale.2018
Effect of Time-Dependent Selective Serotonin Reuptake Inhibitor Antidepressants During Pregnancy on Behavioral, Emotional, and Social Development in Preschool-Aged Children.2018
Maternal mood disorders and lithium exposure in utero were not associated with poor cognitive development during childhood.2018
Gestational Weight Gain and Pre-pregnancy Body Mass Index Associated With Second-Generation Antipsychotic Drug Use During Pregnancy.-- Not Found --
Antidepressant Use in Late Gestation and Breastfeeding Rates at Discharge from Hospital.2017
Antidepressant use during pregnancy and psychiatric disorders in offspring: Danish nationwide register based cohort study.
Risk of preeclampsia after gestational exposure to selective serotonin reuptake inhibitors and other antidepressants: A study from The Norwegian Mother and Child Cohort Study.2017
Use of atypical antipsychotics in pregnancy and maternal gestational diabetes.2017
Antidepressants during pregnancy and autism in offspring: population based cohort study.2017
Association of Antidepressant Medication Use During Pregnancy With Intellectual Disability in Offspring.
Mood symptoms in pregnant and postpartum women with bipolar disorder: a naturalistic study.2017
Antidepressant Use in Pregnancy and the Risk of Attention Deficit with or without Hyperactivity Disorder in Children.2017
Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial.2017
Use of antidepressant medication in pregnancy and adverse neonatal outcomes: A population-based investigation.2017
Lithium Use in Pregnancy and the Risk of Cardiac Malformations.2017
Neonatal Discontinuation Syndrome in Serotonergic Antidepressant-Exposed Neonates.2017
Prenatal antidepressant use and risk of attention-deficit/hyperactivity disorder in offspring: population based cohort study.2017
Autism risk following antidepressant medication during pregnancy.2017
Risk of postpartum episodes in women with bipolar disorder after lamotrigine or lithium use during pregnancy: A population-based cohort study.2017
Pregnancy and postpartum antidepressant use moderates the effects of sleep on depression.2017
The effects of gestational use of antidepressants and antipsychotics on neonatal outcomes for women with severe mental illness.2017
Antidepressant use during pregnancy and the risk of major congenital malformations in a cohort of depressed pregnant women: an updated analysis of the Quebec Pregnancy Cohort.2017
Is the Risk of Preterm Birth and Low Birth Weight Affected by the Use of Antidepressant Agents during Pregnancy? A Population-Based Investigation.2016
Association of Selective Serotonin Reuptake Inhibitor Exposure During Pregnancy With Speech, Scholastic, and Motor Disorders in Offspring.2016
Prenatal exposure to antidepressants and risk of epilepsy in childhood.2016
Prenatal antidepressant exposure and child behavioural outcomes at 7 years of age: a study within the Danish National Birth Cohort.2016
Prenatal exposure to selective serotonin reuptake inhibitors and childhood overweight at 7 years of age.2013
Prenatal exposure to selective serotonin reuptake inhibitors and non-verbal cognitive functioning in childhood.2017
Selective serotonin reuptake inhibitors and autism: additional data on the Quebec Pregnancy/Birth Cohort.2016
Risk of gestational hypertension and preeclampsia in women who discontinued or continued antidepressant medication use during pregnancy.2016
Gestational Exposure to Selective Serotonin Reuptake Inhibitors and Offspring Psychiatric Disorders: A National Register-Based Study.2016
Risk of Miscarriage in Women Receiving Antidepressants in Early Pregnancy, Correcting for Induced Abortions.2016
Preschool outcomes following prenatal serotonin reuptake inhibitor exposure: differences in language and behavior, but not cognitive function.2016
Behavior and inhibitory control in children with prenatal exposure to antidepressants and medically untreated depression.2016
Depression, anxiety, and antidepressant treatment in women: association with in vitro fertilization outcome.2016
The effect of antidepressants on fertility.2016
Antidepressant Use During Pregnancy and the Risk of Autism Spectrum Disorder in Children.2016
The Roles of Maternal Depression, Serotonin Reuptake Inhibitor Treatment, and Concomitant Benzodiazepine Use on Infant Neurobehavioral Functioning Over the First Postnatal Month.2016
Pregnancy Complications Following Prenatal Exposure to SSRIs or Maternal Psychiatric Disorders: Results From Population-Based National Register Data.2015
Methodological considerations in assessing the effectiveness of antidepressant medication continuation during pregnancy using administrative data.2015
Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn.2015
Pregnancy outcome following maternal exposure to mirtazapine: a multicenter, prospective study.2015
Antidepressant medication use, depression, and the risk of preeclampsia.2015
Antidepressant use during pregnancy and asthma in the offspring.2015
No association between prenatal exposure to psychotropics and intelligence at age five.2015
Sertraline use during pregnancy and the risk of major malformations.2015
Treatment of postnatal depression with cognitive behavioural therapy, sertraline and combination therapy: a randomised controlled trial.2015
Maternal use of selective serotonin reuptake inhibitors and risk of miscarriage - assessing potential biases.2015
Impact of prenatal exposure to serotonin reuptake inhibitors or maternal major depressive disorder on infant developmental outcomes.2014
First trimester exposure to anxiolytic and hypnotic drugs and the risks of major congenital anomalies: a United Kingdom population-based cohort study.2014
Antidepressant use in pregnancy and the risk of cardiac defects.2014
Pregnancy outcome following in utero exposure to lithium: a prospective, comparative, observational study.2014
Maternal depression, antidepressant prescriptions, and congenital anomaly risk in offspring: a population-based cohort study.2014
Birth weight and preterm birth in babies of pregnant women with major depression in relation to treatment with antidepressants.2014
Effects of maternal psychotropic drug dosage on birth outcomes.2014
Perinatal outcomes of pregnancies complicated by maternal depression with or without selective serotonin reuptake inhibitor therapy.2014
Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism.2013
Antidepressant exposure in pregnancy and risk of autism spectrum disorders.2013
A randomized, placebo-controlled, double-blind trial of sertraline for postpartum depression.2014
Risk of vaginal bleeding and postpartum hemorrhage after use of antidepressants in pregnancy: a study from the Norwegian Mother and Child Cohort Study.2014
Use of antidepressants near delivery and risk of postpartum hemorrhage: cohort study of low income women in the United States.2013
Antidepressant use and risk for preeclampsia.2013
Does fetal exposure to SSRIs or maternal depression impact infant growth?2013
Neurodevelopment of children following prenatal exposure to venlafaxine, selective serotonin reuptake inhibitors, or untreated maternal depression.2012
Prenatal antidepressant exposure and behavioral problems in early childhood--a cohort study.2013
Prenatal exposure to antidepressants and depressed maternal mood alter trajectory of infant speech perception.2012
Live and non-live pregnancy outcomes among women with depression and anxiety: a population-based study.2012
Neonatal outcomes after late-gestation exposure to selective serotonin reuptake inhibitors.2012
Maternal antidepressant use and adverse outcomes: a cohort study of 228,876 pregnancies.2012
Prenatal antipsychotic exposure and neuromotor performance during infancy.2012
Elevated risk of preeclampsia in pregnant women with depression: depression or antidepressants?2012
Affect Expression and Self-Regulation Capacities of Infants Exposed in utero to Psychotropics.2012
The effect of sertraline add-on to brief dynamic psychotherapy for the treatment of postpartum depression: a randomized, double-blind, placebo-controlled study.2012
Pregnancy outcomes following use of escitalopram: a prospective comparative cohort study.2012
Newborn neurobehavioral patterns are differentially related to prenatal maternal major depressive disorder and serotonin reuptake inhibitor treatment.2011
A prospective, naturalistic, blinded study of early neurobehavioral outcomes for infants following prenatal antidepressant exposure.2011
Association between antidepressant use during pregnancy and infants born small for gestational age.2010
Use of antidepressants during pregnancy and the risk of spontaneous abortion.2010
Antidepressant use during pregnancy and the risk of preterm delivery and fetal growth restriction.2009
Maternal schizophrenia and pregnancy outcome: does the use of antipsychotics make a difference?2010
Selective serotonin reuptake inhibitors in pregnancy and congenital malformations: population based cohort study.
Placental transfer of SSRI and SNRI antidepressants and effects on the neonate.2009
Major depression and antidepressant treatment: impact on pregnancy and neonatal outcomes.2009
Sexual function in postpartum women treated for depression: results from a randomized trial of nortriptyline versus sertraline.2009
Postpartum depression: a randomized trial of sertraline versus nortriptyline.2006
Serotonin reuptake inhibitor use in pregnancy and the neonatal behavioral syndrome.2008
Birth weight of infants after maternal exposure to typical and atypical antipsychotics: prospective comparison study.
Lamotrigine in bipolar disorder: efficacy during pregnancy.2008
Pharmacologic treatment of postpartum women with new-onset major depressive disorder: a randomized controlled trial with paroxetine.2008
Risk of recurrence in women with bipolar disorder during pregnancy: prospective study of mood stabilizer discontinuation.2007
Birth outcomes following prenatal exposure to antidepressants.2007
Risks of congenital malformations and perinatal events among infants exposed to antidepressant medications during pregnancy.2007
Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes.
Effects of antenatal depression and antidepressant treatment on gestational age at birth and risk of preterm birth.2007
First trimester exposure to paroxetine and risk of cardiac malformations in infants: the importance of dosage.2007
Exposure to mirtazapine during pregnancy: a prospective, comparative study of birth outcomes.2006
Patient choice of treatment for postpartum depression: a pilot study.2006
Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health data.2006
Olanzapine in the prevention of postpartum psychosis and mood episodes in bipolar disorder.2006
Internalizing behaviors in 4-year-old children exposed in utero to psychotropic medications.2006
Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatment.2006
Citalopram use in pregnancy: prospective comparative evaluation of pregnancy and fetal outcome.2005
Pregnancy outcome of women exposed to bupropion during pregnancy: a prospective comparative study.2005
Prevention of postpartum episodes in women with bipolar disorder.2004
The impact of depression and fluoxetine treatment on obstetrical outcome.2004
Neonate characteristics after maternal use of antidepressants in late pregnancy.2004
Pharmacologic factors associated with transient neonatal symptoms following prenatal psychotropic medication exposure.2004
Frequency of infant adverse events that are associated with citalopram use during breast-feeding.2004
Follow-up of children of depressed mothers exposed or not exposed to antidepressant drugs during pregnancy.2003
Outcomes of prenatal antidepressant exposure.2002
Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: a prospective, controlled study.2002
Pregnancy outcome following gestational exposure to venlafaxine: a multicenter prospective controlled study.2001
Outcome of children exposed in utero to fluoxetine: a critical review.1998
Pregnancy outcome following first-trimester exposure to fluoxetine (Prozac)1993
A controlled study of fluoxetine and cognitive-behavioural counselling in the treatment of postnatal depression.1997
Neurodevelopment of children exposed in utero to antidepressant drugs.1997
Association of maternal lithium exposure and premature delivery.-- Not Found --
Lithium and pregnancy. A cohort study on manic-depressive women.1983
Hydroxyzine for controlling postpartum anxiety: a double-blind study.1967
One-Year Developmental Outcomes for Infants of Mothers With Bipolar Disorder.-- Not Found --
Continuation of Atypical Antipsychotic Medication During Early Pregnancy and the Risk of Gestational Diabetes.2018
Pregnancy outcomes following maternal exposure to second-generation antipsychotics given with other psychotropic drugs: a cohort study.2013
Exposure to selective serotonin reuptake inhibitors and the risk of congenital malformations: a nationwide cohort study.
Birth weight and use of olanzapine in pregnancy: a prospective comparative study.2010
Risks associated with antipsychotic treatment in pregnancy: Comparative cohort studies based on electronic health records.2016
Zolpidem (Ambien) in pregnancy: placental passage and outcome.2009
Duration of antidepressant use during pregnancy and risk of major congenital malformations.2008
Bipolar disorder and psychotropic medication: Impact on pregnancy and neonatal outcomes.2019
Antipsychotic Use in Pregnancy and the Risk for Congenital Malformations.2016
Risk of adverse perinatal outcomes among women with pharmacologically treated and untreated depression during pregnancy: A retrospective cohort study.2019
Risk of Congenital Heart Disease in Newborns with Prenatal Exposure to Anti-depressant Medications.2019
The association between gestational diabetes mellitus, antipsychotics and severe mental illness in pregnancy: A multicentre study.2020
Association of Maternal Use of Benzodiazepines and Z-Hypnotics During Pregnancy With Motor and Communication Skills and Attention-Deficit/Hyperactivity Disorder Symptoms in Preschoolers.2019
Patterns of prenatal antidepressant exposure and risk of preeclampsia and postpartum haemorrhage.2020
Pregnancy outcomes following maternal venlafaxine use: A prospective observational comparative cohort study.2019
In Utero Antidepressants and Neurodevelopmental Outcomes in Kindergarteners.2020
Obstetric complications in bipolar disorder: Psychiatric factors and the risk of caesarean section.2020
Pregnancy hypertension and its associations with pre-pregnancy depression, anxiety, antidepressants, and anxiolytics.2019
Antidepressant Use around Conception, Prepregnancy Depression, and Risk of Ectopic Pregnancy.2020
Benzodiazepine use before conception and risk of ectopic pregnancy.2020
Antidepressant continuation in pregnancy and risk of gestational diabetes.2019
Association between antidepressant use during pregnancy and autism spectrum disorder in children: a retrospective cohort study based on Japanese claims data.2019
The mother, the infant and the mother-infant relationship: What is the impact of antidepressant medication in pregnancy.2020
Impact of antidepressant use, discontinuation, and dosage modification on maternal depression during pregnancy.2019
Anticonvulsant Mood Stabilizer and Lithium Use and Risk of Adverse Pregnancy Outcomes.2019
The effect of antenatal depression and antidepressant treatment on placental tissue: a protein-validated gene expression study.2019
Maternal and fetal outcomes following exposure to duloxetine in pregnancy: cohort study.2020
Analysis of Perinatal Women Attending a Mother and Baby Unit Taking Sodium Valproate or Lithium with a Diagnosis of Bipolar Affective Disorder.2020
The effect of maternal antidepressants on third trimester uteroplacental hemodynamics and the neonatal abstinence syndrome: a retrospective cohort study.2019
Postpartum Bleeding in Pregnant Women Receiving SSRIs/SNRIs: New Insights From a Descriptive Observational Study and an Analysis of Data from the FAERS Database.2019
Trajectories of antipsychotic use before and during pregnancy and associated maternal and birth characteristics.2019
Association Between Incident Exposure to Benzodiazepines in Early Pregnancy and Risk of Spontaneous Abortion.2019
Maternal Use of Specific Antidepressant Medications During Early Pregnancy and the Risk of Selected Birth Defects.2020
Bupropion in pregnancy and the prevalence of congenital malformations.2007
Comparison of the groups treated with mirtazapine and selective serotonine reuptake inhibitors with respect to birth outcomes and severity of psychiatric disorder2019

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