Skin Substitutes for Treating Chronic Wounds

Project Summary Title and Description

Title
Skin Substitutes for Treating Chronic Wounds
Description
Systematic review to describe skin substitute products commercially available in the United States used to treat chronic wounds, examine systems used to classify skin substitutes, identify and assess randomized controlled trials (RCTs), and suggest best practices for future studies.
Attribution
N/A
Authors of Report
N/A
Methodology description
Systematic review
PROSPERO
N/A
DOI
N/A
Notes
Link to Skin Substitutes for Chronic Wounds. www.cms.gov/medicare-coverage-database/details/technology-assessments-details.aspx?TAId=109&bc=AAAIAAAAAAAA&. Data were entered prospectively using SRDR's built-in data abstraction function and templates.
Funding Source
Agency for Healthcare Research and Quality

Key Questions

1. What are the study design characteristics and wound healing outcomes in each included investigation of skin substitutes for chronic diabetic foot ulcers, venous leg ulcers and pressure injuries?

Associated Extraction Forms

Associated Studies (each link opens a new tab)

TitleAuthorsYear
Diabetic Foot Ulcers Treated With Porcine Urinary Bladder Extracellular Matrix and Total Contact Cast: Interim Analysis of a Randomized, Controlled Trial.2017
Venous Ulcers Treated With a Hyaluronic Acid Extracellular Matrix and Compression Therapy: Interim Analysis of a Randomized Controlled Trial.2017
A multicenter, randomized, single-blind trial comparing the efficacy of viable cryopreserved placental membrane to human fibroblast-derived dermal substitute for the treatment of chronic diabetic foot ulcers.2018
A multicentre randomised controlled trial evaluating the efficacy of dehydrated human amnion/chorion membrane (EpiFix2018
An extracellular matrix graft (Oasis wound matrix) for treating full-thickness pressure ulcers: a randomized clinical trial.2019
A Randomized Controlled Trial Comparing a Human Acellular Dermal Matrix Versus Conventional Care for the Treatment of Venous Leg Ulcers.2019
A randomized clinical trial of a human acellular dermal matrix demonstrated superior healing rates for chronic diabetic foot ulcers over conventional care and an active acellular dermal matrix comparator.2017
Use of an aseptically processed, dehydrated human amnion and chorion membrane improves likelihood and rate of healing in chronic diabetic foot ulcers: A prospective, randomised, multi-centre clinical trial in 80 patients.2018
A clinical trial of Integra Template for diabetic foot ulcer treatment.-- Not Found --
Evaluation of tissue engineering products for the management of neuropathic diabetic foot ulcers: an interim analysis.2016
A prospective, multicentre, randomised controlled study of human fibroblast-derived dermal substitute (Dermagraft) in patients with venous leg ulcers.2013
The efficacy and safety of Grafix(®) for the treatment of chronic diabetic foot ulcers: results of a multi-centre, controlled, randomised, blinded, clinical trial.2014
A prospective, multicenter, randomized, controlled clinical trial comparing a bioengineered skin substitute to a human skin allograft.2014
A multicenter, randomized, controlled clinical trial evaluating the use of dehydrated human amnion/chorion membrane allografts and multilayer compression therapy vs. multilayer compression therapy alone in the treatment of venous leg ulcers.2014
A prospective multicenter randomized controlled clinical trial of a hypothermically stored amniotic membrane for the management of diabetic foot ulcers [manuscript]. 2019
A Prospective, Randomized, Multicenter, Controlled Evaluation of the Use of Dehydrated Amniotic Membrane Allograft Compared to Standard of Care for the Closure of Chronic Diabetic Foot Ulcer.2016
A confirmatory study on the efficacy of dehydrated human amnion/chorion membrane dHACM allograft in the management of diabetic foot ulcers: A prospective, multicentre, randomised, controlled study of 110 patients from 14 wound clinics.
A multicentre prospective randomised controlled comparative parallel study of dehydrated human umbilical cord (EpiCord) allograft for the treatment of diabetic foot ulcers.2019
Randomized, Prospective, Blinded-Enrollment, Head-To-Head Venous Leg Ulcer Healing Trial Comparing Living, Bioengineered Skin Graft Substitute (Apligraf) with Living, Cryopreserved, Human Skin Allograft (TheraSkin).2018
A prospective randomised comparative parallel study of amniotic membrane wound graft in the management of diabetic foot ulcers.2013
Treatment of chronic diabetic lower extremity ulcers with advanced therapies: a prospective, randomised, controlled, multi-centre comparative study examining clinical efficacy and cost.2016
An aseptically processed, acellular, reticular, allogenic human dermis improves healing in diabetic foot ulcers: A prospective, randomised, controlled, multicentre follow-up trial.2018

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