- Nonopioid Pharmacologic Treatments for Chronic Pain
- To evaluate the effectiveness and comparative effectiveness of nonopioid pharmacologic agents in patients with specific types of chronic pain, considering the effects of on pain, function, quality of life, and adverse events.
- Authors of Report
- Methodology description
- Electronic databases (Ovid® MEDLINE®, Embase®, PsycINFO®, CINAHL®, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews) were searched through September 10, 2019. Reference lists, data request, and previous reviews were also sought for potentially eligible studies. Identified citations were screened at abstract level by 1 reviewer and citation deemed not relevant by 1 reviewer was screened by a second reviewer. Full-text articles for citations deemed potentially eligible were screened independently by 2 reviewers. Randomized controlled trials (RCTs) of nonopioid pharmacological agents in patients with chronic pain were selected using predefined criteria and dual review. This review focused on seven common chronic pain conditions (neuropathic pain, fibromyalgia, osteoarthritis, inflammatory arthritis, low back pain, chronic headache, sickle cell disease) with effects analyzed at short term (1 to <6 months following treatment completion), intermediate term (≥6 to <12 months), and long term (≥12 months). Magnitude of effects were described as small, moderate, or large using previously defined criteria, and strength of evidence was assessed. Meta-analyses were conducted where data allowed, stratified by duration within each intervention type, using random effects models. We evaluated effect modification through subgroup and sensitivity analyses, including specific drug, dose, study quality, and pain type. Risk of bias (study quality) assessment followed Cochrane Back and Neck Group and AHRQ EPC Methods Guide.
- DOI: 10.23970/AHRQEPCCER228
Data for this project was entered retrospectively by uploading data to the project from Microsoft Excel.
Evidence tables uploaded:
Appendix E. Study Characteristics
Appendix F1. Data Abstraction of Efficacy Outcomes
Appendix F2. Data Abstraction of Harms Outcomes
Appendix G. Quality Assessment
- Funding Source
- Agency for Healthcare Research and Quality (Contract No. HHSA-290-2015-00009-I)