Interventions for Breathlessness in Patients with Advanced Cancer

Project Summary Title and Description

Title
Interventions for Breathlessness in Patients with Advanced Cancer
Description
To assess benefits and harms of non-pharmacological and pharmacological interventions for breathlessness in adults with advanced cancer.
Attribution
N/A
Authors of Report
N/A
Methodology description
We included randomized controlled trials (RCTs) and observational studies with a comparison group evaluating benefits and/or harms and cohort studies reporting harms. Two reviewers independently screened search results, serially abstracted data, assessed risk of bias and graded strength of evidence (SOE) for key outcomes: breathlessness, anxiety, health-related quality of life (HRQOL) and exercise capacity. We performed meta-analyses when possible and calculated standardized mean differences (SMDs).
PROSPERO
N/A
DOI
N/A
Notes
The published report may be found at: https://effectivehealthcare.ahrq.gov/sites/default/files/pdf/dyspnea-advanced-cancer-report.pdf Data was uploaded retrospectively to SRDR. Each Key Question's data file contains information on study and patient characteristics, intervention information, and detailed outcomes data for both categorical and continuous outcomes. Data files used to synthesis the report are found at: https://srdr.s3.amazonaws.com/uploads/10-29-2021/Breathlessness_compiled+data_KQ1_KQ4.xlsx https://srdr.s3.amazonaws.com/uploads/10-29-2021/Breathlessness_compiled+data_KQ2_KQ4.xlsx https://srdr.s3.amazonaws.com/uploads/10-29-2021/Breathlessness_compiled+data_KQ3_KQ4.xlsx
Funding Source
N/A

Key Questions

1. Key Question 1. What are the comparative benefits of non-pharmacological interventions (either alone or in combination) for improving breathlessness in patients with advanced cancer?
2. Key Question 2. What are the comparative benefits of pharmacological interventions (either alone or in combination) for improving breathlessness in patients with advanced cancer?
3. Key Question 3. What are the comparative benefits of non-pharmacological, pharmacological, and multimodal interventions for improving breathlessness in patients with advanced cancer?
4. Key Question 4. What are the harms of non-pharmacological and pharmacological interventions for improving breathlessness in patients with advanced cancer?

Associated Extraction Forms

Associated Studies (each link opens a new tab)

TitleAuthorsYear
High-flow oxygen and bilevel positive airway pressure for persistent dyspnea in patients with advanced cancer: a phase II randomized trial.2013
Palliative use of non-invasive ventilation in end-of-life patients with solid tumours: a randomised feasibility trial.2013
Management of the respiratory distress symptom cluster in lung cancer: a randomised controlled feasibility trial.2015
The Effect of Using an Electric Fan on Dyspnea in Chinese Patients With Terminal Cancer.2017
A comparison of the effects of medical Qigong and standard exercise therapy on symptoms and quality of life in patients with advanced cancer.2017
The effect of resistance inspiratory muscle training in the management of breathlessness in patients with thoracic malignancies: a feasibility randomised trial.2015
A randomized controlled trial of supplemental oxygen versus air in cancer patients with dyspnea.2003
Does oxygen help dyspnea in patients with cancer?1996
A randomized, double-blind, crossover trial of the effect of oxygen on dyspnea in patients with advanced cancer.2006
Non-pharmacological intervention for breathlessness in lung cancer.1996
Effects of oxygen on dyspnoea in hypoxaemic terminal-cancer patients.1993
Managing symptoms in patients with advanced lung cancer during radiotherapy: results of a psychoeducational randomized controlled trial.2011
Effects of exercise training on exercise capacity in patients with non-small cell lung cancer receiving targeted therapy.2012
Is a specialist breathlessness service more effective and cost-effective for patients with advanced cancer and their carers than standard care? Findings of a mixed-method randomised controlled trial.2014
Health-related quality-of-life outcomes: a reflexology trial with patients with advanced-stage breast cancer.2012
Strength and endurance training in the treatment of lung cancer patients in stages IIIA/IIIB/IV.2014
The Effects of Acupressure on Quality of Life and Dyspnea in Lung Cancer: A Randomized, Controlled Trial.2020
Fan Therapy Is Effective in Relieving Dyspnea in Patients With Terminally Ill Cancer: A Parallel-Arm, Randomized Controlled Trial.2018
EEG-Based Analysis of the Emotional Effect of Music Therapy on Palliative Care Cancer Patients.2018
Quality of life in a randomized trial of group psychosocial support in metastatic breast cancer: overall effects of the intervention and an exploration of missing data.2003
Using the COPE intervention for family caregivers to improve symptoms of hospice homecare patients: a clinical trial.2007
Nurse led follow up and conventional medical follow up in management of patients with lung cancer: randomised trial.2002
Acupuncture for dyspnea in advanced cancer: a randomized, placebo-controlled pilot trial ISRCTN89462491.2005
Acceptance and Commitment Therapy for Symptom Interference in Advanced Lung Cancer and Caregiver Distress: A Pilot Randomized Trial.
Effects of transcutaneous electrical nerve stimulation on physical symptoms in advanced cancer patients receiving palliative care.2020
Exercise Training in Patients With Non-Small Cell Lung Cancer During In-Hospital Chemotherapy Treatment: A RANDOMIZED CONTROLLED TRIAL.2019
Randomized trial of a physical activity intervention in women with metastatic breast cancer.2016
Impact of physical activity on fatigue and quality of life in people with advanced lung cancer: a randomized controlled trial.2017
The FAFA Trial: A Phase 2 Randomized Clinical Trial on the Effect of a Fan Blowing Air on the Face to Relieve Dyspnea in Filipino Patients with Terminal Cancer2020
Effect of Prophylactic Fentanyl Buccal Tablet on Episodic Exertional Dyspnea: A Pilot Double-Blind Randomized Controlled Trial.2017
Buspirone for management of dyspnea in cancer patients receiving chemotherapy: a randomized placebo-controlled URCC CCOP study.2016
Impact of Prophylactic Fentanyl Pectin Nasal Spray on Exercise-Induced Episodic Dyspnea in Cancer Patients: A Double-Blind, Randomized Controlled Trial.2016
Dexamethasone for Dyspnea in Cancer Patients: A Pilot Double-Blind, Randomized, Controlled Trial.2016
EffenDys-Fentanyl Buccal Tablet for the Relief of Episodic Breathlessness in Patients With Advanced Cancer: A Multicenter, Open-Label, Randomized, Morphine-Controlled, Crossover, Phase II Trial.2016
Effects of prophylactic subcutaneous fentanyl on exercise-induced breakthrough dyspnea in cancer patients: a preliminary double-blind, randomized, controlled trial.
A randomized crossover clinical trial to evaluate the efficacy of oral transmucosal fentanyl citrate in the treatment of dyspnea on exertion in patients with advanced cancer.2015
Continuous subcutaneous infusion of compound oxycodone for the relief of dyspnea in patients with terminally ill cancer: a retrospective study.2013
Effect of intraoral and subcutaneous morphine on dyspnea at rest in terminal patients with primary lung cancer or lung metastases.-- Not Found --
Morphine versus midazolam as upfront therapy to control dyspnea perception in cancer patients while its underlying cause is sought or treated.2010
Midazolam as adjunct therapy to morphine in the alleviation of severe dyspnea perception in patients with advanced cancer.2006
Nebulized versus subcutaneous morphine for patients with cancer dyspnea: a preliminary study.2005
Relief of incident dyspnea in palliative cancer patients: a pilot, randomized, controlled trial comparing nebulized hydromorphone, systemic hydromorphone, and nebulized saline.2008
How effective are supplementary doses of opioids for dyspnea in terminally ill cancer patients? A randomized continuous sequential clinical trial.1999
Subcutaneous morphine for dyspnea in cancer patients.1993
Morphine versus methylprednisolone or aminophylline for relieving dyspnea in patients with advanced cancer in China: a retrospective study.2016
Prophylactic Fentanyl Sublingual Spray for Episodic Exertional Dyspnea in Cancer Patients: A Pilot Double-Blind Randomized Controlled Trial.2019
A randomised, double-blind controlled trial of intranasal midazolam for the palliation of dyspnoea in patients with life-limiting disease.2016
Oral morphine drops for prompt relief of breathlessness in patients with advanced cancer-a randomized, double blinded, crossover trial of morphine sulfate oral drops vs. morphine hydrochloride drops with ethanol (red morphine drops).2020
A randomised study comparing the effectiveness of acupuncture or morphine versus the combination for the relief of dyspnoea in patients with advanced non-small cell lung cancer and mesothelioma.2016
Effects of prophylactic subcutaneous fentanyl on exercise-induced breakthrough dyspnea in cancer patients: a preliminary double-blind, randomized, controlled trial.2014

Downloadable Data Content

Files
  • XLSX Project Data