Acute Pain Updates

Project Summary Title and Description

Acute Pain Updates
Data for three surveillance reports for the 2020 report Treatments for Acute Pain: A Systematic Review ( The 2020 report addressed benefits and harms of opioid, nonopioid pharmacologic, and nonpharmacologic treatments for specific types of acute pain (low back pain, neck pain, other musculoskeletal pain, neuropathic pain, postoperative pain [excluding inpatient management of pain after major surgical procedures], dental pain, pain due to kidney stones, and pain due to sickle cell disease). Given the clinical and public health importance of this topic, it is important to identify new evidence that could impact practice or policy. The purpose of this update was to identify new evidence published since the original 2020 report, and to determine how the new evidence impacts the findings of the original 2020 report.
Authors of Report
Roger Chou, M.D., FACP Jessica C. Griffin, M.S. Ian Blazina, M.P.H. Eli Schwarz, D.D.S., Ph.D., M.P.H. Chandler Atchison, M.P.H. Kim Mauer, M.D.
Methodology description
Systematic Review
The data was entered prospectively using SRDR+'s data abstraction function and templates. Final reports can be found here:
Funding Source
Agency for Healthcare Research and Quality

Key Questions

1. KQ1: Acute back pain (including back pain with radiculopathy)
2. KQ2: Acute neck pain (including neck pain with radiculopathy)
3. KQ3: Musculoskeletal pain not otherwise included in KQ1 or KQ2 (including fractures)
4. KQ4: Peripheral neuropathic pain (related to herpes zoster and trigeminal neuralgia)
5. KQ5: Postoperative pain (excluding inpatient management of pain following major surgical procedures)
6. KQ6: Dental pain (surgical and nonsurgical)
7. KQ7: Kidney stones (including inpatient management)
8. KQ8: Sickle cell crisis (episodic pain)

Associated Extraction Forms


Associated Studies (each link opens a new tab)

Title Authors Year
A randomized controlled trial of oxycodone/acetaminophen versus acetaminophen alone for emergency department patients with musculoskeletal pain refractory to ibuprofen. Friedman Benjamin W, Irizarry Eddie, Feliciano Carmen, Izzo Albert J, Borrayes Lester, Restivo Andrew, Costa Vincent, Bijur Polly E 2021
Acupuncture for acute non-specific low back pain: a randomised, controlled, multicentre intervention study in general practice-the Acuback study. Skonnord Trygve, Skjeie Holgeir, Brekke Mette, Klovning Atle, Grotle Margreth, Aas Eline, Mdala Ibrahimu, Fetveit Arne 2020
Efficacy and safety of two fixed-dose combinations of tramadol hydrochloride and diclofenac sodium in postoperative dental pain. Desjardins Paul, Alvarado Fabian, Gil Martha, González Manuel, Guajardo Rogelio 2020
Abdominal ice after laparoscopic hysterectomy: a randomized controlled trial Cope Adela G, Wetzstein Marnie M, Mara Kristin C, Laughlin-Tommaso Shannon K, Warner Nafisseh S, Burnett Tatnai L 2021
Comparison between isolated and associated with codeine acetaminophen in pain control of acute apical abscess: a randomized clinical trial. da Silva Paula Barcellos, Mendes Aline Teixeira, Cardoso Maria Beatriz Ferreira, da Rosa Ricardo Abreu, do Nascimento Angela Longo, Pereira Jefferson Ricardo, Só Marcus Vinícius Reis 2021
Patient-centered decision-making for postoperative narcotic-free endocrine surgery: a randomized clinical trial. Zhu Catherine Y, Schumm Max A, Hu Theodore X, Nguyen Dalena T, Kim Jiyoon, Tseng Chi-Hong, Lin Anne Y, Yeh Michael W, Livhits Masha J, Wu James X 2021
The role of computer-assisted cryotherapy in the postoperative treatment after total knee arthroplasty: positive effects on pain and opioid consumption. Brouwers Hugo F G, de Vries A J, van Zuilen M, van Kouswijk H W, Brouwer R W 2021
Effect of acetaminophen on postoperative percocet use in hip arthroscopy: a randomized controlled trial. Bloom David A, Kirby David J, Thompson Kamali, Baron Samuel L, Chee Crist, Youm Thomas 2021
Effect of applying cold gel pack on reduction of postoperative pain in cesarean section, low midline skin incision: A randomized controlled trial. Suwannalert Pawitra, Chanthasenanont Athita, Pongrojpaw Densak 2021
The effect of preoperative opioid education on opioid consumption after outpatient orthopedic surgery: a prospective randomized trial. Ilyas Asif M, Chapman Talia, Zmistowski Benjamin, Sandrowski Kristin, Graham Jack, Hammoud Sommer 2021 Mar-Apr
Tapentadol vs oxycodone for postoperative pain treatment the first 7 days after total knee arthroplasty: a randomized clinical trial. Rian Torbjørn, Skogvoll Eirik, Hofstad Janne, Høvik Lise, Winther Siri B, Husby Vigdis Schnell, Klaksvik Jomar, Egeberg Tarjei, Sand Kari, Klepstad Pål, Wik Tina Strømdal 2021
Prospective randomized trial comparing opioids versus nonsteroidal anti inflammatory drugs for postoperative analgesia in outpatient rhinoplasty Frants Anna, Garber David, Lafer Marissa P, Gordon Steven A, Markey Jeffrey D, Zhang Yan, Wang Binhuan, Lee Judy W 2021
Prospective randomized study evaluating the effects of preoperative opioid counseling on postoperative opioid use after outpatient lower extremity orthopaedic surgery. Paskey Taylor, Vincent Sage, Critchlow Elizabeth, Mann Erica, Chapman Talia, Aland Christopher, Dodson Christopher, Emper William, Freedman Kevin B, Pedowitz David, Ilyas Asif M 2021
Topical capsaicin versus topical ibuprofen in acute musculoskeletal injuries: a randomized, double-blind trial Akgol Gur, S. T., Dogruyol, S., Kocak, A. O., Sanalp Menekse, T., Akbas, I., Betos Kocak, M., Cakir, Z. 2020
Efficacy of routinely used analgesics in management of pulpal pain postoperatively a clinical study. Thota Lavanya, Bansal Rahul, Thota Gunaranjan, Chikkanna Meena Kumari, Shanab Hanan, Kumari Vinutha V 2021
A randomized controlled trial of music for pain relief after arthroplasty surgery. Laframboise-Otto Joanne M, Horodyski MaryBeth, Parvataneni Hari K, Horgas Ann L 2021
Analgesic efficacy of naproxen sodium versus hydrocodone/acetaminophen in acute postsurgical dental pain: a randomized, double-blind, placebo-controlled trial. Cooper Stephen A, Desjardins Paul J, Bertoch Todd, Paredes-Diaz Alberto, Troullos Emanuel, Tajaddini Azita, Centofanti Robert, An Robert, Morella Donna 2021
A mixed-methods study of the effect of abdominal binders on opioid use and postoperative pain after cesarean birth. Hoskins Corie, Dempsey Amy, Brou Lina 2022
Transcutaneous electric nerve stimulation reduces acute postoperative pain and analgesic use after open inguinal hernia surgery: a randomized, double-blind, placebo-controlled trial. Parseliunas Audrius, Paskauskas Saulius, Kubiliute Egle, Vaitekunas Jovydas, Venskutonis Donatas 2021
Analgesic efficacy of tramadol/dexketoprofen vs ibuprofen after impacted lower third molar extraction: a randomized controlled clinical trial Vallecillo Cristina, Vallecillo-Rivas Marta, Gálvez Rafael, Vallecillo-Capilla Manuel, Olmedo-Gaya María Victoria 2021

Downloadable Data Content

  • XLSX Project Data