ESP Troponin ADPs

Project Summary Title and Description

Title
ESP Troponin ADPs
Description
(Comparative) effectiveness of accelerated diagnostic protocols that use high sensitivity cardiac troponin assays in the Emergency Dept
Attribution
This report was prepared by the Evidence Synthesis Program Center located at the Providence VA Health Care System, directed by Eric Jutkowitz, PhD and James L. Rudolph, MD, and funded by the Department of Veterans Affairs, Health Services Research and Development.
Authors of Report
Jonie J Hsiao, MD Manuel A Celedon James L Rudolph Kristin J Konnyu Sebhat A Erqou Muhammad Baig Thomas A Trikalinos Kyari Sumayin Ngamdu Ghid Kanaan Sunny Cui Thien Phuc Tran Taylor Rickard Ethan M Balk Eric Jutkowitz (Lead)
Methodology description
Systematic Review
PROSPERO
CRD42022343247
DOI
N/A
Notes
Report available at: Accelerated Diagnostic Protocols Using High-sensitivity Troponin Assays to “Rule In” or “Rule Out” Myocardial Infarction in the Emergency Department: A Systematic Review. Jutkowitz E, Hsiao J, Celedon M, Erqou S, Konnyu K, Rudolph J, Baig M, Trikalinos T, Ngamdu K, Kanaan G, Tran TP, Rickard T, Cui S, Balk E. Washington (DC): Department of Veterans Affairs (US); 2023 Mar. PMID: 37579034 Data were entered into this project prospectively (using SRDR's built-in data abstraction function and templates). KQ 1: Among adults presenting to the emergency department with suspected acute coronary syndrome, what is the (comparative) effectiveness of accelerated diagnostic protocols that use high sensitivity cardiac troponin assays on: i) clinical outcomes (eg., myocardial infarction, mortality, and major adverse cardiac events) within 6 weeks? ii) health service use (eg., duration of emergency department stay, duration of hospitalization, readmission) within 6 weeks? KQ 1a: Does effectiveness differ as a function of patient characteristics (eg., gender, chest pain duration, clinical risk score)? KQ1b: What is the performance of accelerated diagnostic protocols that use 1-hour delta troponin compared to accelerated diagnostic protocols that use 2-hour delta troponin? KQ 2: What are the clinical and health service use outcomes among adults presenting to the emergency department with suspected acute coronary syndrome who have indeterminant (“grey” or “observational” zone) results of accelerated diagnostic protocols? KQ 2a: Do clinical and health service outcomes differ as a function of patient characteristics (eg, gender, chest pain duration, clinical risk score)?
Funding Source
Department of Veterans Affairs, Health Services Research and Development.

Key Questions

1. ADP effectiveness

Associated Extraction Forms

Type
Standard

Associated Studies (each link opens a new tab)

Title Authors Year
A Rule-Out Strategy Based on High-Sensitivity Troponin and HEART Score Reduces Hospital Admissions. Ljung Lina, Lindahl Bertil, Eggers Kai M, Frick Mats, Linder Rikard, Löfmark Henrik B, Martinsson Arne, Melki Dina, Sarkar Nondita, Svensson Per, Jernberg Tomas 2019
High-Sensitivity Cardiac Troponin on Presentation to Rule Out Myocardial Infarction: A Stepped-Wedge Cluster Randomized Controlled Trial. Anand Atul, Lee Kuan Ken, Chapman Andrew R, Ferry Amy V, Adamson Phil D, Strachan Fiona E, Berry Colin, Findlay Iain, Cruikshank Anne, Reid Alan, Collinson Paul O, Apple Fred S, McAllister David A, Maguire Donogh, Fox Keith A A, Newby David E, Tuck Chris, Harkess Ronald, Keerie Catriona, Weir Christopher J, Parker Richard A, Gray Alasdair, Shah Anoop S V, Mills Nicholas L, HiSTORIC Investigators† 2021
Single high-sensitivity troponin levels to assess patients with potential acute coronary syndromes. Barnes Cara, Fatovich Daniel M, Macdonald Stephen P J, Alcock Richard F, Spiro Jon R, Briffa Tom G, Schultz Carl J, Hillis Graham S 2021
Reducing avoidable chest pain admissions and implementing high-sensitivity troponin testing. zzz_Bhatti Yousaf, Stevenson Alexander, Weerasuriya Scott, Khan Sadia 2019
Limit of detection of troponin discharge strategy versus usual care: randomised controlled trial. zzz_Carlton Edward Watts, Ingram Jenny, Taylor Hazel, Glynn Joel, Kandiyali Rebecca, Campbell Sarah, Beasant Lucy, Aziz Shahid, Beresford Peter, Kendall Jason, Reuben Adam, Smith Jason E, Chapman Rebecca, Creanor Siobhan, Benger Jonathan Richard 2020
Impact of high-sensitivity Troponin T on hospital admission, resources utilization, and outcomes. zzz_Corsini Anna, Vagnarelli Fabio, Bugani Giulia, Bacchi Reggiani Maria Letizia, Semprini Franco, Nanni Samuele, Cinti Laura, Norscini Giulia, Vannini Antonio, Beltrandi Elisabetta, Cavazza Mario, Branzi Angelo, Rapezzi Claudio, Melandri Giovanni 2015
The impact of high-sensitivity troponin implementation on hospital operations and patient outcomes in 3 tertiary care centers. Crowder Kathryn R, Jones Tristan D, Lang Eddy S, Wang Dongmei M, Clark Steven M, Innes Grant D, McMeekin James D, Graham Michelle M, McRae Andrew D 2015
Impact of high-sensitivity cardiac troponin implementation on emergency department length of stay, testing, admissions, and diagnoses. Ford James S, Chaco Ernestine, Tancredi Daniel J, Mumma Bryn E 2021
Impact of the HEART Pathway on Admission Rates for Emergency Department Patients with Chest Pain: An External Clinical Validation Study. Hyams Jessica M, Streitz Matthew J, Oliver Joshua J, Wood Richard M, Maksimenko Yevgeniy M, Long Brit, Barnwell Robert M, April Michael D 2018
Late Outcomes of the RAPID-TnT Randomized Controlled Trial: 0/1-Hour High-Sensitivity Troponin T Protocol in Suspected ACS. Lambrakis Kristina, Papendick Cynthia, French John K, Quinn Stephen, Blyth Andrew, Seshadri Anil, Edmonds Michael J R, Chuang Anthony, Khan Ehsan, Nelson Adam J, Wright Deborah, Horsfall Matthew, Morton Erin, Karnon Jonathan, Briffa Tom, Cullen Louise A, Chew Derek P 2021
A single centre prospective cohort study addressing the effect of a rule-in/rule-out troponin algorithm on routine clinical practice. zzz_Marjot Jack, Kaier Thomas E, Henderson Katherine, Hunter Laura, Marber Michael S, Perera Divaka 2019
Effect of Using the HEART Score in Patients With Chest Pain in the Emergency Department: A Stepped-Wedge, Cluster Randomized Trial. zzz_Poldervaart Judith M, Reitsma Johannes B, Backus Barbra E, Koffijberg Hendrik, Veldkamp Rolf F, Ten Haaf Monique E, Appelman Yolande, Mannaerts Herman F J, van Dantzig Jan-Melle, van den Heuvel Madelon, El Farissi Mohamed, Rensing Bernard J W M, Ernst Nicolette M S K J, Dekker Ineke M C, den Hartog Frank R, Oosterhof Thomas, Lagerweij Ghizelda R, Buijs Eugene M, van Hessen Maarten W J, Landman Marcel A J, van Kimmenade Roland R J, Cozijnsen Luc, Bucx Jeroen J J, van Ofwegen-Hanekamp Clara E E, Cramer Maarten-Jan, Six A Jacob, Doevendans Pieter A, Hoes Arno W 2017
Implementation of an early rule-out pathway for myocardial infarction using a high-sensitivity cardiac troponin T assay. Sandeman Dennis, Syed Maaz B J, Kimenai Dorien M, Lee Kuan Ken, Anand Atul, Joshi Shruti S, Dinnel Lorraine, Wenham Philip R, Campbell Ken, Jarvie Mary, Galloway Donna, Anderson Mhairi, Roy Bappa, Andrews Jack P M, Strachan Fiona E, Ferry Amy V, Chapman Andrew R, Elsby Sarah, Francis Mark, Cargill Robert, Shah Anoop S V, Mills Nicholas L 2021
RAPID-CPU: a prospective study on implementation of the ESC 0/1-hour algorithm and safety of discharge after rule-out of myocardial infarction. Stoyanov Kiril M, Hund Hauke, Biener Moritz, Gandowitz Jochen, Riedle Christoph, Löhr Julia, Mueller-Hennessen Matthias, Vafaie Mehrshad, Katus Hugo A, Giannitsis Evangelos 2020
Impact of a rapid high-sensitivity troponin pathway on patient flow in an urban emergency department. Suh Edward Hyun, Tichter Aleksandr M, Ranard Lauren S, Amaranto Andrew, Chang Betty C, Huynh Phong Anh, Kratz Alexander, Lee Rebekah Jihae, Rabbani LeRoy E, Sacco Dana, Einstein Andrew J 2022
The impact of an acute chest pain pathway on the investigation and management of cardiac chest pain. Sweeney Mark, Bleeze Gillian, Storey Sarah, Cairns Alexander, Taylor Alexander, Holmes Catherine, Hart Steve, Lawrance Nick, Oldfield William G, Baker Christopher S 2020
Effectiveness of EDACS Versus ADAPT Accelerated Diagnostic Pathways for Chest Pain: A Pragmatic Randomized Controlled Trial Embedded Within Practice. Than Martin P, Pickering John W, Aldous Sally J, Cullen Louise, Frampton Christopher M A, Peacock W Frank, Jaffe Allan S, Goodacre Steve W, Richards A Mark, Ardagh Michael W, Deely Joanne M, Florkowski Chris M, George Peter, Hamilton Gregory J, Jardine David L, Troughton Richard W, van Wyk Pieter, Young Joanna M, Bannister Laura, Lord Sally J 2016
Reducing Patient Risk and Enhancing Care Through the Development and Implementation of a New Chest Pain Pathway, Expedited by and for the COVID-19 Era. Than Martin P, Pickering John W, Adamson Philip, Clendon Thomas, Florkowski Christopher M, Lainchbury John, Loubser Jacques, Nankivel Alison, Aldous Sally J 2021
Association of a Novel Protocol for Rapid Exclusion of Myocardial Infarction With Resource Use in a US Safety Net Hospital. Vigen Rebecca, Diercks Deborah B, Hashim Ibrahim A, Pandey Ambarish, Zhong Lin, Kutscher Patricia, Fernandez Fernabelle, Yu Amy, Bertulfo Bryan, Molberg Kyle, Metzger Jeffery C, Soto Jose, Alzubaidy Dergham, Thibodeaux Lorie, Joglar Jose A, Das Sandeep R, de Lemos James A 2020
Evaluation of a new diagnostic algorithm for acute coronary syndrome using high-sensitivity troponin T assay Costabel-2014 2014
Results of the first patients with suspected acute coronary syndrome evaluated with the 1-hour algorithm proposed by the European Society of Cardiology zzz_Costabel-2019 2019
A study on modified accelerated diagnostic protocol to safely discharge low-risk chest pain patients in emergency department zzz_Yean-2020 2020
A Randomized Trial of a 1-Hour Troponin T Protocol in Suspected Acute Coronary Syndromes: The Rapid Assessment of Possible Acute Coronary Syndrome in the Emergency Department With High-Sensitivity Troponin T Study (RAPID-TnT). Chew Derek P, Lambrakis Kristina, Blyth Andrew, Seshadri Anil, Edmonds Michael J R, Briffa Tom, Cullen Louise A, Quinn Stephen, Karnon Jonathan, Chuang Anthony, Nelson Adam J, Wright Deborah, Horsfall Matthew, Morton Erin, French John K, Papendick Cynthia 2019
Algorithm for probable acute coronary syndrome using high-sensitivity troponin T assay vs fourth-generation troponin T assay. Conde Diego, Costabel Juan Pablo, Lambardi Florencia 2013
Outcome of Applying the ESC 0/1-hour Algorithm in Patients With Suspected Myocardial Infarction. Twerenbold Raphael, Costabel Juan Pablo, Nestelberger Thomas, Campos Roberto, Wussler Desiree, Arbucci Rosina, Cortes Marcia, Boeddinghaus Jasper, Baumgartner Benjamin, Nickel Christian H, Bingisser Roland, Badertscher Patrick, Puelacher Christian, du Fay de Lavallaz Jeanne, Wildi Karin, Rubini Giménez Maria, Walter Joan, Meier Mario, Hafner Benjamin, Lopez Ayala Pedro, Lohrmann Jens, Troester Valentina, Koechlin Luca, Zimmermann Tobias, Gualandro Danielle M, Reichlin Tobias, Lambardi Florencia, Resi Silvana, Alves de Lima Alberto, Trivi Marcelo, Mueller Christian 2019
Beyond triage: the diagnostic accuracy of emergency department nursing staff risk assessment in patients with suspected acute coronary syndromes. Carlton Edward Watts, Khattab Ahmed, Greaves Kim 2016

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