Extraction form for project: Management of Infantile Epilepsies

Design Details

1. Study Design
2. Country
3. Total sample size
4. Intervention Type
5. Funding source

Arms

Arm NameArm Description
Temporal lobe resection
Frontal lobe resection
Hemispherotomy

Arm Details

1. Sample size for arm
Temporal lobe resection
Frontal lobe resection
Hemispherotomy
2. Inclusion Criteria
Temporal lobe resection
Frontal lobe resection
Hemispherotomy
3. Exclusion Criteria
Temporal lobe resection
Frontal lobe resection
Hemispherotomy
4. Treatment details
Temporal lobe resection
Frontal lobe resection
Hemispherotomy

Sample Characteristics

1. Gender, number of male
Temporal lobe resection
Frontal lobe resection
Hemispherotomy
Total
2. Gender, percentage of male
Temporal lobe resection
Frontal lobe resection
Hemispherotomy
Total
3. Age at intervention (mean)
Temporal lobe resection
Frontal lobe resection
Hemispherotomy
Total
4. Age at intervention (SD)
Temporal lobe resection
Frontal lobe resection
Hemispherotomy
Total
5. Age at intervention (range)
Temporal lobe resection
Frontal lobe resection
Hemispherotomy
Total
6. Age at intervention (median)
Temporal lobe resection
Frontal lobe resection
Hemispherotomy
Total
7. Seizure types and/or etiology
Temporal lobe resection
Frontal lobe resection
Hemispherotomy
Total
8. Prior treatment
Temporal lobe resection
Frontal lobe resection
Hemispherotomy
Total
9. Comments
Temporal lobe resection
Frontal lobe resection
Hemispherotomy
Total

Outcomes

TypeDomainSpecific measurement (i.e., tool/definition/specific outcome)PopulationsTimepoints
CategoricalSeizure freedom
  • All Participants
  • 2 years after surgery
CategoricalSeizure reduction (>75% reduction)
  • All Participants
  • 2 years after surgery
CategoricalSeizure reduction (50-74% reduction)
  • All Participants
  • 2 years after surgery
CategoricalSeizure reduction (0-49% reduction)
  • All Participants
  • 2 years after surgery
CategoricalIncrease frequency
  • All Participants
  • 2 years after surgery
CategoricalAdverse EventVP shunt
  • Hemispherectomy
  • Within 2 years
CategoricalSeizure freedom hemispherectomy/hemispherotomy
  • All Participants
  • 2 years after surgery
CategoricalSeizure frequency hemispherectomy/hemispherotomy
  • All Participants
  • 2 years after surgery
CategoricalSeizure freedom temporal/frontal Lobe resection
  • All Participants
  • 2 years after surgery
CategoricalSeizure frequency temporal/frontal Lobe resection
  • All Participants
  • 2 years after surgery

Outcome Details

1. For RCTs: Generation of randomization sequence
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
2. For RCTs: Allocation concealment
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
3. For RCTs: Baseline imbalance
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
4. For RCTs: Patient blinded
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
5. For RCTs: Staff blinded
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
6. For RCTs: Differential ancillary treatments
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
7. For RCTs: Adherence
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
8. For RCTs: Analytic approach to address departures from intended intervention
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
9. For RCTs: Data on at least 80% of those enrolled
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
10. For RCTs: Differential dropout <=15%
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
11. For RCTs: Standard way to measure the outcome
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
12. For RCTs: Blinded outcome assessor
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
13. For RCTs: Bias in selection of reported results
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
14. For nonrandomized comparative studies: Confounding
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
15. For nonrandomized comparative studies: Selection into study
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
16. For nonrandomized comparative studies: Classification of interventions
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
17. For nonrandomized comparative studies: Differential ancillary treatments
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
18. For nonrandomized comparative studies: Adherence
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
19. For nonrandomized comparative studies: Data on at least 80% of those enrolled
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
20. For nonrandomized comparative studies: Differential dropout <=15%
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
21. For nonrandomized comparative studies: Standard way to measure the outcome
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
22. For nonrandomized comparative studies: Blinded outcome assessor
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
23. For nonrandomized comparative studies: Bias in selection of reported result
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
24. For single arm studies: Does the design or analysis control account for important confounding and modifying variables through matching, stratification, multivariable analysis, or other approaches?
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
25. For single arm studies: Did researchers rule out any impact from a concurrent intervention or an unintended exposure that might bias results?
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
26. For single arm studies: Did the study maintain fidelity to the intervention protocol?
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
27. For single arm studies: If attrition (overall or differential nonresponse, dropout, loss to follow-up, or exclusion of participants) was a concern, were missing data handled appropriately (e.g., intention-to-treat analysis and imputation)?
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
28. For single arm studies: Were the outcome assessors blinded to the intervention or exposure status of participants?
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
29. For single arm studies: Were interventions/exposures assessed/defined using valid and reliable measures, implemented consistently across all study participants?
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
30. For single arm studies: Were outcomes assessed/defined using valid and reliable measures, implemented consistently across all study participants?
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
31. For single arm studies: Were confounding variables assessed using valid and reliable measures, implemented consistently across all study participants?
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection
32. For single arm studies: Were the potential outcomes prespecified by the researchers? Are all prespecified outcomes reported?
Seizure freedom
Seizure reduction (>75% reduction)
Seizure reduction (50-74% reduction)
Seizure reduction (0-49% reduction)
Increase frequency
Adverse Event
Seizure freedom hemispherectomy/hemispherotomy
Seizure frequency hemispherectomy/hemispherotomy
Seizure freedom temporal/frontal Lobe resection
Seizure frequency temporal/frontal Lobe resection

Risk of Bias Assessment

1. For Risk of Bias Assessment results, see Outcome Details section.

Results

Categorical


Seizure freedom

All Participants
Descriptive StatisticsBetween Arm Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy
2 years after surgery
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy

Seizure reduction (>75% reduction)

All Participants
Descriptive StatisticsBetween Arm Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy
2 years after surgery
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy

Seizure reduction (50-74% reduction)

All Participants
Descriptive StatisticsBetween Arm Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy
2 years after surgery
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy

Seizure reduction (0-49% reduction)

All Participants
Descriptive StatisticsBetween Arm Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy
2 years after surgery
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy

Increase frequency

All Participants
Descriptive StatisticsBetween Arm Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy
2 years after surgery
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy

Adverse Event (VP shunt)

Hemispherectomy
Descriptive StatisticsBetween Arm Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy
Within 2 years
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy

Seizure freedom hemispherectomy/hemispherotomy

All Participants
Descriptive StatisticsBetween Arm Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy
2 years after surgery
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy

Seizure frequency hemispherectomy/hemispherotomy

All Participants
Descriptive StatisticsBetween Arm Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy
2 years after surgery
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy

Seizure freedom temporal/frontal Lobe resection

All Participants
Descriptive StatisticsBetween Arm Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy
2 years after surgery
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy

Seizure frequency temporal/frontal Lobe resection

All Participants
Descriptive StatisticsBetween Arm Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy
2 years after surgery
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
Temporal lobe resectionFrontal lobe resectionHemispherotomy