Extraction form for project: Interventional Treatments for Acute and Chronic Pain: Systematic Review

Design Details

1. Trial Intervention
Input which intervention is being studied
2. Trial Name
3. Setting
Country
4. Study Design
5. Mean Age (Years)
Input the mean age for the entire sample
6. Percent Female
Input the whole number here for the entire study sample - no need to add %
7. Number Randomized
8. Pain Duration Measure (Mean, Median)
9. Pain Duration (Weeks)
10. Duration of Followup (Months)

Arms

Arm NameArm Description
Intradiscal allogenic mesenchymal precursor cells6 million cells (1.0 mL of the 30 million/5 mL MPC product) mixed with 1.0 mL of 1% hyaluronic acid
Intradiscal allogenic mesenchymal precursor cells18 million cells (1.0 mL of the 90 million/5 mL MPC product) mixed with 1.0 mL of 1% hyaluronic acid
Intradiscal hyaluronic acid2 ml of 1% hyaluronic acid
Intradiscal saline2 ml sterile saline

Arm Details

N/A

Sample Characteristics

N/A

Outcomes

TypeDomainSpecific measurement (i.e., tool/definition/specific outcome)PopulationsTimepoints
ContinuousPainVAS LSM (95% CI)
  • All Participants
  • 1 (month)
  • 3 (months)
  • 6 (months)
  • 1 (year)
  • 2 (years)
  • 3 (years)
ContinuousFunctionODI LSM (95% CI)
  • All Participants
  • 1 (month)
  • 3 (months)
  • 6 (months)
  • 1 (year)
  • 2 (years)
  • 3 (years)

Outcome Details

N/A

Risk of Bias Assessment

1. What kind of study is this?
2. Randomization adequate?
3. Allocation concealment adequate?
4. Groups similar at baseline?
5. Outcome assessors masked?
6. Care provider masked?
7. Patient masked?
8. Acceptable levels of overall attrition and between-group differences in attrition?
9. Intention-to-Treat (ITT) analysis?
10. Avoidance of selective outcomes reporting
11. Quality rating

Results

Continuous


Pain (VAS LSM (95% CI))

All Participants
Descriptive StatisticsBetween Arm Comparisons
Intradiscal allogenic mesenchymal precursor cellsIntradiscal allogenic mesenchymal precursor cellsIntradiscal hyaluronic acidIntradiscal saline
1 (month)
least square mean
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
3 (months)
least square mean
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
6 (months)
least square mean
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
1 (year)
least square mean
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
2 (years)
least square mean
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
3 (years)
least square mean
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
Within Arm ComparisonsNet Comparisons
Intradiscal allogenic mesenchymal precursor cellsIntradiscal allogenic mesenchymal precursor cellsIntradiscal hyaluronic acidIntradiscal saline

Function (ODI LSM (95% CI))

All Participants
Descriptive StatisticsBetween Arm Comparisons
Intradiscal allogenic mesenchymal precursor cellsIntradiscal allogenic mesenchymal precursor cellsIntradiscal hyaluronic acidIntradiscal saline
1 (month)
least square mean
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
3 (months)
least square mean
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
6 (months)
least square mean
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
1 (year)
least square mean
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
2 (years)
least square mean
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
3 (years)
least square mean
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
Within Arm ComparisonsNet Comparisons
Intradiscal allogenic mesenchymal precursor cellsIntradiscal allogenic mesenchymal precursor cellsIntradiscal hyaluronic acidIntradiscal saline