Extraction form for project: Interventional Treatments for Acute and Chronic Pain: Systematic Review

Design Details

1. Trial Intervention
Input which intervention is being studied
2. Trial Name
3. Setting
Country
4. Study Design
5. Mean Age (Years)
Input the mean age for the entire sample
6. Percent Female
Input the whole number here for the entire study sample - no need to add %
7. Number Randomized
8. Pain Duration Measure (Mean, Median)
9. Pain Duration (Weeks)
10. Duration of Followup (Months)

Arms

Arm NameArm Description
Intradiscal methylene blue1 mL (1%; 10 mg/mL) methylene blue + 1 ml lidocaine hydrochloride 2%
Sham intradiscal injection1 ml saline + 1 ml lidocaine hydrochloride 2%

Arm Details

N/A

Sample Characteristics

N/A

Outcomes

TypeDomainSpecific measurement (i.e., tool/definition/specific outcome)PopulationsTimepoints
ContinuousPainNRS 0 to 10, mean difference (95% CI)
  • All Participants
  • 6 (months)
  • 1 (year)
  • 2 (years)
ContinuousFunctionODI 0 to 100, mean difference (95% CI)
  • All Participants
  • 6 (months)
  • 1 (year)
  • 2 (years)

Outcome Details

N/A

Risk of Bias Assessment

1. What kind of study is this?
2. Randomization adequate?
3. Allocation concealment adequate?
4. Groups similar at baseline?
5. Outcome assessors masked?
6. Care provider masked?
7. Patient masked?
8. Acceptable levels of overall attrition and between-group differences in attrition?
9. Intention-to-Treat (ITT) analysis?
10. Avoidance of selective outcomes reporting
11. Quality rating

Results

Continuous


Pain (NRS 0 to 10, mean difference (95% CI))

All Participants
Descriptive StatisticsBetween Arm Comparisons
Intradiscal methylene blueSham intradiscal injection
6 (months)
mean difference
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
1 (year)
mean difference
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
2 (years)
mean difference
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
Within Arm ComparisonsNet Comparisons
Intradiscal methylene blueSham intradiscal injection

Function (ODI 0 to 100, mean difference (95% CI))

All Participants
Descriptive StatisticsBetween Arm Comparisons
Intradiscal methylene blueSham intradiscal injection
6 (months)
mean difference
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
1 (year)
mean difference
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
2 (years)
mean difference
Mean Difference (MD)
95% CI low
95% CI low (MD)
95% CI high
95% CI high (MD)
SD (MD)
p value (MD)
Within Arm ComparisonsNet Comparisons
Intradiscal methylene blueSham intradiscal injection