Nutrition as Prevention for Improved Cancer Health Outcomes

Project Summary Title and Description

Nutrition as Prevention for Improved Cancer Health Outcomes
Objective. To understand the evidence base for nutrition interventions delivered prior to or during cancer treatment for preventing and treating negative cancer and cancer treatment-related outcomes among individuals with or at risk for malnutrition. The primary purpose was to inform the NIH Pathways to Prevention workshop, Nutrition as Prevention for Improved Cancer Health Outcomes, held July 26 – 28, 2022. Data Sources. We searched Ovid Medline, Ovid Embase, and Cochrane Central Register of Controlled Trials to identify studies from 2000 through July, 2022. We conducted grey literature searches to identify additional resources relevant to the associated costs or value (e.g., cost-effectiveness, cost-benefit) of nutrition interventions Review Methods. We searched for studies that evaluated a broad range of nutrition interventions (e.g., dietary supplements, nutrition support, nutrition counseling) for preventing and treating negative outcomes of cancer and cancer-related treatment. Eligible studies included randomized controlled trials (RCT) with enrollment ≥50 participants. We extracted basic study information from all eligible studies, then grouped studies by broad intervention and cancer types. We provide a detailed evidence map for all included studies, but conducted risk of bias and additional qualitative descriptions of outcomes for only those intervention and cancer types with a larger volume of literature. Results. We identified 9,798 unique references, with 206 studies from 219 publications reporting RCTs of nutrition interventions to potentially improve negative outcomes of cancer and cancer–related treatment. Two decades of randomized trial evidence on nutrition interventions for adults prior to and/or during cancer treatment primarily focused on dietary supplements, nutrition support (including oral nutrition supplements), and the route or timing of nutrition interventions within gastrointestinal and head and neck cancers in the inpatient setting. Most studies evaluated changes in weight/body composition, adverse events, length of hospital stay and quality of life. Among intervention and cancer types with a high volume of literature (n=114), which predominately included studies in dietary supplements and nutrition support in gastrointestinal and head and neck cancers, 11 percent (n=12) were rated as low risk of bias (higher quality), 40percent (n=46) medium risk of bias, and 49 percent (n=56) high risk of bias (lower quality). Low- and medium-risk-of-bias studies reported mixed results on the effect of nutrition interventions across cancer and treatment-related outcomes. Although the evidence map shows a large volume of studies evaluating nutrition interventions and outcomes, studies showed high heterogeneity across study populations, interventions, and outcomes (measure definitions, timing of measurements), even within nutrition intervention categories, therefore we could not aggregate results. While studies enrolled individuals from multiple cancer types, treatments, and stages, across the lifespan, with varying degrees of muscle wasting, and in those with a range of comorbid conditions, no eligible studies specifically evaluated whether the effects of nutrition interventions on preventing negative outcomes varied across these characteristics. Among studies included in our Key Questions, we found that few (4 percent, n=8) published cost or value (e.g., cost-effectiveness, cost-benefit) information related to the intervention. In our grey literature search of additional studies examining cost or value of nutrition interventions, we found few studies that conducted cost-effectiveness or cost-benefit analyses, and, among those, found mixed results on the value of nutrition interventions in non-U.S. health systems. Conclusions. Although overall RCT evidence focused on a wide range of nutrition interventions, studies were concentrated in use of dietary supplements, nutrition support, and the route or timing of nutrition interventions within gastrointestinal and head and neck cancers in inpatient settings. Among interventions with the highest volume of literature, the majority of studies were rated as of high risk of bias. Our findings point to the need for rigorous new research to bolster the evidence base. Specifically, the field needs a more detailed future evaluation of a subset of nutrition interventions contained in this evidence map that focus on priorities most relevant to specific stakeholders (e.g., oncologists, patients, dietitians, researchers, policymakers). Further, studies should be specifically designed to evaluate the main outcomes of interest for clinical practice. Future research would also benefit from creation of standardized taxonomies for interventions and outcomes as well as more rigorous design and reporting of nutrition interventions. As mentioned, heterogeneity of populations, interventions, comparators and outcomes precluded aggregation. Currently, the quality and heterogeneity of the studies limit the ability to translate findings into clinical practice or guidelines. In order to inform development of these guidelines, coordinated efforts are required to develop detailed conceptual frameworks for mechanisms of nutrition interventions most relevant to clinical care providers and patients. Such frameworks would help inform priorities for future research as well as guide practice and policy.
University of Minnesota
Authors of Report
Helen M. Parsons, Ph.D., M.P.H. Mary Forte, Ph.D., D.C. Hamdi I. Abdi, M.P.H. Sallee Brandt, M.P.H. Amy Claussen, M.L.I.S. Timothy J. Wilt, M.D., M.P.H. Mark Klein, M.D. Elizabeth Ester, M.D. Adrienne Landsteiner, Ph.D., M.P.H. Aasma Shaukat, M.D., M.P.H. Shalamar Sibley, M.D., M.P.H. Joanne Slavin, Ph.D., R.D. Catherine Sowerby, B.A. Weiwen Ng, M.P.H Mary Butler, Ph.D., M.B.A.
Methodology description
Systematic Review
Link to protocol: Data was entered retrospectively using SRDR+'s built-in data abstraction function by copying data from Excel.
Funding Source
National Institutes of Health (NIH), Agency for Healthcare Research and Quality (AHRQ)

Key Questions

1. KQ1: In adults diagnosed with cancer who have or are at risk for cancer-associated malnutrition, what is the effect of nutrition interventions prior to cancer treatment in preventing negative treatment outcomes such as effects on dose tolerance, hospital utilizations, adverse events and survival?
2. KQ2: In adults diagnosed with cancer who have or are at risk for cancer-associated malnutrition, what is the effect of nutrition interventions during cancer treatment in preventing negative treatment outcomes such as effects on dose tolerance, hospital utilizations, adverse events and survival?
3. KQ3: In adults diagnosed with cancer who have or are at risk for cancer-associated malnutrition, what is the effect of nutrition interventions prior to or during cancer treatment on associated symptoms such as fatigue, nausea and vomiting, appetite, physical and functional status (e.g., frailty), and quality of life?
4. KQ4: In adults with cancer who are overweight or obese, what is the effect of nutrition interventions intended for weight loss prior to or during cancer treatment in preventing negative treatment outcomes such as effects on dose, hospital utilizations, adverse events and survival?

Associated Extraction Forms


Associated Studies (each link opens a new tab)

Title Authors Year
The Effect of Dietary Intervention Along with Nutritional Education on Reducing the Gastrointestinal Side Effects Caused by Chemotherapy Among Women with Breast Cancer Abdollahi, R.;Najafi, S.;Razmpoosh, E.;Shoormasti, R. S.;Haghighat, S.;Raji Lahiji, M.;Chamari, M.;Asgari, M.;Cheshmazar, E.;Zarrati, M. 2019
The utility of nutritional supportive care with an eicosapentaenoic acid (EPA)-enriched nutrition agent during pre-operative chemoradiotherapy for pancreatic cancer: Prospective randomized control study Akita, H.;Takahashi, H.;Asukai, K.;Tomokuni, A.;Wada, H.;Marukawa, S.;Yamasaki, T.;Yanagimoto, Y.;Takahashi, Y.;Sugimura, K.;Yamamoto, K.;Nishimura, J.;Yasui, M.;Omori, T.;Miyata, H.;Ochi, A.;Kagawa, A.;Soh, Y.;Taniguchi, Y.;Ohue, M.;Yano, M.;Sakon, M. 2019
Efficacy of Ginger in Control of Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients Receiving Doxorubicin-Based Chemotherapy Ansari, M.;Porouhan, P.;Mohammadianpanah, M.;Omidvari, S.;Mosalaei, A.;Ahmadloo, N.;Nasrollahi, H.;Hamedi, S. H. 2016
Quality of life after early enteral feeding versus standard care for proven or suspected advanced epithelial ovarian cancer: Results from a randomised trial Baker, J.;Janda, M.;Graves, N.;Bauer, J.;Banks, M.;Garrett, A.;Chetty, N.;Crandon, A. J.;Land, R.;Nascimento, M.;Nicklin, J. L.;Perrin, L. C.;Obermair, A. 2015
Simple nutritional intervention in patients with advanced cancers of the gastrointestinal tract, non-small cell lung cancers or mesothelioma and weight loss receiving chemotherapy: a randomised controlled trial Baldwin, C.;Spiro, A.;McGough, C.;Norman, A. R.;Gillbanks, A.;Thomas, K.;Cunningham, D.;O'Brien, M.;Andreyev, H. J. 2011
Prospective multicentre randomised controlled trial of early enteral nutrition for patients undergoing major upper gastrointestinal surgical resection Barlow, R.;Price, P.;Reid, T. D.;Hunt, S.;Clark, G. W.;Havard, T. J.;Puntis, M. C.;Lewis, W. G. 2011
Direct Oral Feeding Following Minimally Invasive Esophagectomy (NUTRIENT II trial): An International, Multicenter, Open-label Randomized Controlled Trial Berkelmans, G. H. K.;Fransen, L. F. C.;Dolmans-Zwartjes, A. C. P.;Kouwenhoven, E. A.;van Det, M. J.;Nilsson, M.;Nieuwenhuijzen, G. A. P.;Luyer, M. D. P. 2020
Reduction of postoperative ileus by early enteral nutrition in patients undergoing major rectal surgery: prospective, randomized, controlled trial Boelens, P. G.;Heesakkers, F. F.;Luyer, M. D.;van Barneveld, K. W.;de Hingh, I. H.;Nieuwenhuijzen, G. A.;Roos, A. N.;Rutten, H. J. 2014
Impact on Health-Related Quality of Life of Parenteral Nutrition for Patients with Advanced Cancer Cachexia: Results from a Randomized Controlled Trial Bouleuc, C.;Anota, A.;Cornet, C.;Grodard, G.;Thiery-Vuillemin, A.;Dubroeucq, O.;Cretineau, N.;Frasie, V.;Gamblin, V.;Chvetzoff, G.;Favier, L.;Tournigand, C.;Grach, M. C.;Raynard, B.;Salas, S.;Capodano, G.;Pazart, L.;Aubry, R. 2020
Nutritional advice in older patients at risk of malnutrition during treatment for chemotherapy: a two-year randomized controlled trial Bourdel-Marchasson, I.;Blanc-Bisson, C.;Doussau, A.;Germain, C.;Blanc, J. F.;Dauba, J.;Lahmar, C.;Terrebonne, E.;Lecaille, C.;Ceccaldi, J.;Cany, L.;Lavau-Denes, S.;Houede, N.;Chomy, F.;Durrieu, J.;Soubeyran, P.;Senesse, P.;Chene, G.;Fonck, M. 2014
Nutritional approach in malnourished surgical patients: a prospective randomized study Braga, M.;Gianotti, L.;Nespoli, L.;Radaelli, G.;Di Carlo, V. 2002
Eating As Treatment (EAT): A Stepped-Wedge, Randomized Controlled Trial of a Health Behavior Change Intervention Provided by Dietitians to Improve Nutrition in Patients With Head and Neck Cancer Undergoing Radiation Therapy (TROG 12.03) Britton, B.;Baker, A. L.;Wolfenden, L.;Wratten, C.;Bauer, J.;Beck, A. K.;McCarter, K.;Harrowfield, J.;Isenring, E.;Tang, C.;Oldmeadow, C.;Carter, G. 2019
Impact of early prophylactic feeding on long term tube dependency outcomes in patients with head and neck cancer Brown, T.;Banks, M.;Hughes, B. G. M.;Lin, C.;Kenny, L. M.;Bauer, J. D. 2017
Pre-operative oral nutritional supplementation with dietary advice versus dietary advice alone in weight-losing patients with colorectal cancer: single-blind randomized controlled trial Burden, S. T.;Gibson, D. J.;Lal, S.;Hill, J.;Pilling, M.;Soop, M.;Ramesh, A.;Todd, C. 2017
An unblinded randomised controlled trial of preoperative oral supplements in colorectal cancer patients Burden, S. T.;Hill, J.;Shaffer, J. L.;Campbell, M.;Todd, C. 2011
The role of immunonutrition in gynecologic oncologic surgery Celik, J. B.;Gezginc, K.;Ozcelik, K.;Celik, C. 2009
Nutritional counseling with or without systematic use of oral nutritional supplements in head and neck cancer patients undergoing radiotherapy Cereda, E.;Cappello, S.;Colombo, S.;Klersy, C.;Imarisio, I.;Turri, A.;Caraccia, M.;Borioli, V.;Monaco, T.;Benazzo, M.;Pedrazzoli, P.;Corbella, F.;Caccialanza, R. 2018
Whey protein isolate supplementation improves body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy Cereda, E.;Turri, A.;Klersy, C.;Cappello, S.;Ferrari, A.;Filippi, A. R.;Brugnatelli, S.;Caraccia, M.;Chiellino, S.;Borioli, V.;Monaco, T.;Stella, G. M.;Arcaini, L.;Benazzo, M.;Grugnetti, G.;Pedrazzoli, P.;Caccialanza, R. 2019
The effects of multi-oil fat emulsion on older patients with gastric cancer Chen, H.;Pan, D.;Li, L. 2017
Effect of family enteral nutrition on nutritional status in elderly patients with esophageal carcinoma after minimally invasive radical surgery: a randomized trial Chen, T.;Jiang, W.;He, G. 2021
Home enteral nutrition for postoperative elderly patients with esophageal cancer Chen, X.;Zhao, G.;Zhu, L. 2021
Omega-3 Fatty Acids Supplementation Improve Nutritional Status and Inflammatory Response in Patients With Lung Cancer: A Randomized Clinical Trial Cheng, M.;Zhang, S.;Ning, C.;Huo, Q. 2021
Arginine, glutamine, and fish oil supplementation in cancer patients treated with concurrent chemoradiotherapy: A randomized control study Chitapanarux, I.;Traisathit, P.;Chitapanarux, T.;Jiratrachu, R.;Chottaweesak, P.;Chakrabandhu, S.;Rasio, W.;Pisprasert, V.;Sripan, P. 2020
Effects of Single Nucleotide Polymorphisms and Mediterranean Diet in Overweight or Obese Postmenopausal Women With Breast Cancer Receiving Adjuvant Hormone Therapy: A Pilot Randomized Controlled Trial Cho, A. R.;Hong, K. W.;Kwon, Y. J.;Choi, J. E.;Lee, H. S.;Kim, H. M.;Bae, S. J.;Ahn, S. G.;Jeong, J.;Lee, J. W. 2022
Evaluation of effects of nutritional risk assessment and enteral and parenteral nutritional interventions after esophageal cancer surgery Chu, L.;Ren, Y.;Zhang, L.;Yu, X. 2018
Efficacy of glutamine-supplemented parenteral nutrition on short-term survival following allo-SCT: a randomized study da Gama Torres, H. O.;Vilela, E. G.;da Cunha, A. S.;Goulart, E. M.;Souza, M. H.;Aguirre, A. C.;Azevedo, W. M.;Lodi, F. M.;Silva, A. A.;Bittencourt, H. N. 2008
A randomized controlled trial evaluating early versus traditional oral feeding after colorectal surgery Dag, A.;Colak, T.;Turkmenoglu, O.;Gundogdu, R.;Aydin, S. 2011
Randomized clinical trial with an enteral arginine-enhanced formula in early postsurgical head and neck cancer patients de Luis, D. A.;Izaola, O.;Cuellar, L.;Terroba, M. C.;Aller, R. 2004
A randomized clinical trial with oral Immunonutrition (omega3-enhanced formula vs. arginine-enhanced formula) in ambulatory head and neck cancer patients de Luis, D. A.;Izaola, O.;Aller, R.;Cuellar, L.;Terroba, M. C. 2005
Clinical and biochemical outcomes after a randomized trial with a high dose of enteral arginine formula in postsurgical head and neck cancer patients de Luis, D. A.;Izaola, O.;Cuellar, L.;Terroba, M. C.;Martin, T.;Aller, R. 2007
A randomized clinical trial with two omega 3 fatty acid enhanced oral supplements in head and neck cancer ambulatory patients de Luis, D. A.;Izaola, O.;Aller, R.;Cuellar, L.;Terroba, M. C.;Martin, T. 2008
High dose of arginine enhanced enteral nutrition in postsurgical head and neck cancer patients. A randomized clinical trial De Luis, D. A.;Izaola, O.;Cuellar, L.;Terroba, M. C.;Martin, T.;Aller, R. 2009
A randomized double-blind clinical trial with two different doses of arginine enhanced enteral nutrition in postsurgical cancer patients De Luis, D. A.;Izaola, O.;Cuellar, L.;Terroba, M. C.;Martin, T.;Ventosa, M. 2010
Effect of three different doses of arginine enhanced enteral nutrition on nutritional status and outcomes in well nourished postsurgical cancer patients: a randomized single blinded prospective trial De Luis, D. A.;Izaola, O.;Terroba, M. C.;Cuellar, L.;Ventosa, M.;Martin, T. 2015
Parenteral fish oil as a pharmacological agent to modulate post-operative immune response: a randomized, double-blind, and controlled clinical trial in patients with gastrointestinal cancer de Miranda Torrinhas, R. S.;Santana, R.;Garcia, T.;Cury-Boaventura, M. F.;Sales, M. M.;Curi, R.;Waitzberg, D. L. 2013
Benefits of immunonutrition in patients with head and neck cancer receiving chemoradiation: A phase II randomized, double-blind study Dechaphunkul, T.;Arundon, T.;Raungkhajon, P.;Jiratrachu, R.;Geater, S. L.;Dechaphunkul, A. 2022
Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy Demark-Wahnefried, W.;Case, L. D.;Blackwell, K.;Marcom, P. K.;Kraus, W.;Aziz, N.;Snyder, D. C.;Giguere, J. K.;Shaw, E. 2008
Effects of preoperative and postoperative enteral nutrition on postoperative nutritional status and immune function of gastric cancer patients Ding, D.;Feng, Y.;Song, B.;Gao, S.;Zhao, J. 2015
Oral Nutritional Supplementation in Cancer Patients Who Were Receiving Chemo/Chemoradiation Therapy: A Multicenter, Randomized Phase II Study Faccio, A. A.;Mattos, Chps;Santos, Easd;Neto, N. R. M.;Moreira, R. P.;Luciara Tonelo, Batella;Santos, H. D.;Celes, A. P. M. 2021
Reduced infections with perioperative immunonutrition in head and neck cancer: exploratory results of a multicenter, prospective, randomized, double-blind study Falewee, M. N.;Schilf, A.;Boufflers, E.;Cartier, C.;Bachmann, P.;Pressoir, M.;Banal, A.;Michel, C.;Ettaiche, M. 2014
Effect of early postoperative enteral immunonutrition on wound healing in patients undergoing surgery for gastric cancer Farreras, N.;Artigas, V.;Cardona, D.;Rius, X.;Trias, M.;Gonzalez, J. A. 2005
Effects of omega-3 supplementation on the nutritional status, immune, and inflammatory profiles of gastric cancer patients: A randomized controlled trial Feijo, P. M.;Rodrigues, V. D.;Viana, M. S.;Dos Santos, M. P.;Abdelhay, E.;Viola, J. P.;de Pinho, N. B.;Martucci, R. B. 2019
Effects of preoperative oral carbohydrate administration combined with postoperative early oral intake in elderly patients undergoing hepatectomy with acute-phase inflammation and subjective symptom burden: A prospective randomized controlled study Feng, J.;Xu, R.;Li, K.;Li, F.;Gao, M.;Han, Q.;Feng, H.;Ye, H. 2022
Early oral feeding after colorectal resection: a randomized controlled study Feo, C. V.;Romanini, B.;Sortini, D.;Ragazzi, R.;Zamboni, P.;Pansini, G. C.;Liboni, A. 2004
A disease-specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: results of a randomized, controlled, multicenter trial Fietkau, R.;Lewitzki, V.;Kuhnt, T.;Holscher, T.;Hess, C. F.;Berger, B.;Wiegel, T.;Rodel, C.;Niewald, M.;Hermann, R. M.;Lubgan, D. 2013
Effects of a nutrition intervention on acute and late bowel symptoms and health-related quality of life up to 24 months post radiotherapy in patients with prostate cancer: a multicentre randomised controlled trial Forslund, M.;Ottenblad, A.;Ginman, C.;Johansson, S.;Nygren, P.;Johansson, B. 2020
Effect of early oral feeding on gastrointestinal function recovery in postoperative gastric cancer patients: a prospective study Gao, L.;Zhao, Z.;Zhang, L.;Shao, G. 2019
Randomized comparison of cooked and noncooked diets in patients undergoing remission induction therapy for acute myeloid leukemia Gardner, A.;Mattiuzzi, G.;Faderl, S.;Borthakur, G.;Garcia-Manero, G.;Pierce, S.;Brandt, M.;Estey, E. 2008
Impact of home enteral nutrition in malnourished patients with upper gastrointestinal cancer: A multicentre randomised clinical trial Gavazzi, C.;Colatruglio, S.;Valoriani, F.;Mazzaferro, V.;Sabbatini, A.;Biffi, R.;Mariani, L.;Miceli, R. 2016
A double blind, randomised, placebo controlled, feasibility phase III clinical trial ofperi-operative immune-enhancing enteral nutrition in patients undergoing surgery for advanced head and neck cancer Ghosh, Samit;Dempsey, Ged;Skelly, Rachel;Shaw, Richard J.;Rogers, Simon N.;Lowe, Derek;Jones, Terence M. 2012
A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer Gianotti, L.;Braga, M.;Nespoli, L.;Radaelli, G.;Beneduce, A.;Di Carlo, V. 2002
Strain-specific probiotic (microbial cell preparation) and omega-3 fatty acid in modulating quality of life and inflammatory markers in colorectal cancer patients: a randomized controlled trial Golkhalkhali, B.;Rajandram, R.;Paliany, A. S.;Ho, G. F.;Wan Ishak, W. Z.;Johari, C. S.;Chin, K. F. 2018
Randomized Study Design to Test Effects of Vitamin D and Omega-3 Fatty Acid Supplementation as Adjuvant Therapy in Colorectal Cancer Patients Haidari, F.;Abiri, B.;Iravani, M.;Ahmadi-Angali, K.;Vafa, M. 2020
The impact of preoperative carbohydrate loading on intraoperative body temperature: a randomized controlled clinical trial Hamamoto, H.;Yamamoto, M.;Masubuchi, S.;Ishii, M.;Osumi, W.;Tanaka, K.;Okuda, J.;Uchiyama, K. 2018
Randomised controlled trial of intermittent vs continuous energy restriction during chemotherapy for early breast cancer Harvie, M.;Pegington, M.;Howell, S. J.;Bundred, N.;Foden, P.;Adams, J.;Graves, L.;Greystoke, A.;Mattson, M. P.;Cutler, R. G.;Williamson, J.;Livingstone, K.;McMullen, D.;Sellers, K.;Lombardelli, C.;Cooper, G.;McDiarmid, S.;Howell, A. 2022
Effects of Preoperative Oral Nutritional Supplements on Improving Postoperative Early Enteral Feeding Intolerance and Short-Term Prognosis for Gastric Cancer: A Prospective, Single-Center, Single-Blind, Randomized Controlled Trial He, F. J.;Wang, M. J.;Yang, K.;Chen, X. L.;Jin, T.;Zhu, L. L.;Zhuang, W. 2022
Does Prolonged Enteral Feeding With Supplemental Omega-3 Fatty Acids Impact on Recovery Post-esophagectomy: Results of a Randomized Double-Blind Trial Healy, L. A.;Ryan, A.;Doyle, S. L.;Ni Bhuachalla, E. B.;Cushen, S.;Segurado, R.;Murphy, T.;Ravi, N.;Donohoe, C. L.;Reynolds, J. V. 2017
Early enteral nutrition in combination with parenteral nutrition in elderly patients after surgery due to gastrointestinal cancer Huang, D.;Sun, Z.;Huang, J.;Shen, Z. 2015
Post-esophagectomy tube feeding: a retrospective comparison of jejunostomy and a novel gastrostomy feeding approach Huang, K.;Wu, B.;Ding, X.;Xu, Z.;Tang, H. 2014
A prospective randomized controlled trial on the value of prophylactic oral nutritional supplementation in locally advanced nasopharyngeal carcinoma patients receiving chemo-radiotherapy Huang, S.;Piao, Y.;Cao, C.;Chen, J.;Sheng, W.;Shu, Z.;Hua, Y.;Jiang, F.;Hu, Q.;Chen, X.;Chen, Y. 2020
Supportive nutrition on recovery of metabolism, nutritional state, health-related quality of life, and exercise capacity after major surgery: a randomized study Hyltander, A.;Bosaeus, I.;Svedlund, J.;Liedman, B.;Hugosson, I.;Wallengren, O.;Olsson, U.;Johnsson, E.;Kostic, S.;Henningsson, A.;Korner, U.;Lundell, L.;Lundholm, K. 2005
Randomized clinical trial comparing standard diet with perioperative oral immunonutrition in total gastrectomy for gastric cancer Ida, S.;Hiki, N.;Cho, H.;Sakamaki, K.;Ito, S.;Fujitani, K.;Takiguchi, N.;Kawashima, Y.;Nishikawa, K.;Sasako, M.;Aoyama, T.;Honda, M.;Sato, T.;Nunobe, S.;Yoshikawa, T. 2017
Effects of an Oral Elemental Nutritional Supplement on Post-gastrectomy Body Weight Loss in Gastric Cancer Patients: A Randomized Controlled Clinical Trial Imamura, H.;Nishikawa, K.;Kishi, K.;Inoue, K.;Matsuyama, J.;Akamaru, Y.;Kimura, Y.;Tamura, S.;Kawabata, R.;Kawada, J.;Fujiwara, Y.;Kawase, T.;Fukui, J.;Takagi, M.;Takeno, A.;Shimokawa, T. 2016
Effect of concord grape juice on chemotherapy-induced nausea and vomiting: results of a pilot study Ingersoll, G. L.;Wasilewski, A.;Haller, M.;Pandya, K.;Bennett, J.;He, H.;Hoffmire, C.;Berry, C. 2010
Nutrition intervention is beneficial in oncology outpatients receiving radiotherapy to the gastrointestinal or head and neck area Isenring, E. A.;Capra, S.;Bauer, J. D. 2004
Efficacy and safety of an amino acid jelly containing coenzyme Q10 and L-carnitine in controlling fatigue in breast cancer patients receiving chemotherapy: a multi-institutional, randomized, exploratory trial (JORTC-CAM01) Iwase, S.;Kawaguchi, T.;Yotsumoto, D.;Doi, T.;Miyara, K.;Odagiri, H.;Kitamura, K.;Ariyoshi, K.;Miyaji, T.;Ishiki, H.;Inoue, K.;Tsutsumi, C.;Sagara, Y.;Yamaguchi, T. 2016
Efficacy of EPA-enriched supplement compared with standard formula on body weight changes in malnourished patients with head and neck cancer undergone surgery: a randomized study Jantharapattana, K.;Orapipatpong, O. 2020
"Enjoy glass of wine before eating:" a randomized trial to test the orexigenic effects of this advice in advanced cancer patients Jatoi, A.;Qin, R.;Satele, D.;Dakhil, S.;Kumar, P.;Johnson, D. B.;Thomas, S. P.;Stella, P. J.;Castillo, J.;Li, M.;Fernandez-Zapico, M. 2016
Benefits of Oral Nutritional Supplements in Patients with Locally Advanced Nasopharyngeal Cancer during Concurrent Chemoradiotherapy: An Exploratory Prospective Randomized Trial Jiang, W.;Ding, H.;Li, W.;Ling, Y.;Hu, C.;Shen, C. 2018
Randomized clinical trial of intravenous soybean oil alone versus soybean oil plus fish oil emulsion after gastrointestinal cancer surgery Jiang, Z. M.;Wilmore, D. W.;Wang, X. R.;Wei, J. M.;Zhang, Z. T.;Gu, Z. Y.;Wang, S.;Han, S. M.;Jiang, H.;Yu, K. 2010
Effects of Post-Surgical Parenteral Nutrition on Patients with Gastric Cancer Jin, Y.;Yong, C.;Ren, K.;Li, D.;Yuan, H. 2018
Missing effect of glutamine supplementation on the surgical outcome after pancreaticoduodenectomy for periampullary tumors: a prospective, randomized, double-blind, controlled clinical trial Jo, S.;Choi, S. H.;Heo, J. S.;Kim, E. M.;Min, M. S.;Choi, D. W.;Seo, J. M.;Chung, J. C.;Kim, Y. I. 2006
Preoperative nutritional support in cancer patients with no clinical signs of malnutrition--prospective randomized controlled trial Kabata, P.;Jastrzebski, T.;Kakol, M.;Krol, K.;Bobowicz, M.;Kosowska, A.;Jaskiewicz, J. 2015
Comparison of three different treatment modalities in the management of cancer cachexia Kanat, O.;Cubukcu, E.;Avci, N.;Budak, F.;Ercan, I.;Canhoroz, M.;Olmez, F. 2013
Randomized study of prevention of gastrointestinal toxicities by nutritional support using an amino acid-rich elemental diet during chemotherapy in patients with esophageal cancer (KDOG 1101) Katada, C.;Fukazawa, S.;Sugawara, M.;Sakamoto, Y.;Takahashi, K.;Takahashi, A.;Watanabe, A.;Wada, T.;Ishido, K.;Furue, Y.;Harada, H.;Hosoda, K.;Yamashita, K.;Hiki, N.;Sato, T.;Ichikawa, T.;Shichiri, M.;Tanabe, S.;Koizumi, W. 2021
Is preoperative protein-rich nutrition effective on postoperative outcome in non-small cell lung cancer surgery? A prospective randomized study Kaya, S. O.;Akcam, T. I.;Ceylan, K. C.;Samancilar, O.;Ozturk, O.;Usluer, O. 2016
Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study Khodabakhshi, A.;Akbari, M. E.;Mirzaei, H. R.;Mehrad-Majd, H.;Kalamian, M.;Davoodi, S. H. 2020
Clinical effect of enteral nutrition support during neoadjuvant chemotherapy on the preservation of skeletal muscle mass in patients with esophageal cancer Kita, R.;Miyata, H.;Sugimura, K.;Tanaka, K.;Makino, T.;Yamashita, K.;Yamasaki, M.;Motoori, M.;Shiraishi, O.;Kimura, Y.;Yasuda, T.;Yano, M.;Doki, Y. 2021
The clinical value of parenteral immunonutrition in surgical patients Klek, S.;Kulig, J.;Szczepanik, A. M.;Jedrys, J.;Kolodziejczyk, P. 2005
Standard and immunomodulating enteral nutrition in patients after extended gastrointestinal surgery--a prospective, randomized, controlled clinical trial Klek, S.;Kulig, J.;Sierzega, M.;Szczepanek, K.;Szybinski, P.;Scislo, L.;Walewska, E.;Kubisz, A.;Szczepanik, A. M. 2008
Perioperative nutrition in malnourished surgical cancer patients - a prospective, randomized, controlled clinical trial Klek, S.;Sierzega, M.;Szybinski, P.;Szczepanek, K.;Scislo, L.;Walewska, E.;Kulig, J. 2011
Effect of perioperative oral nutritional supplementation in malnourished patients who undergo gastrectomy: A prospective randomized trial Kong, S. H.;Lee, H. J.;Na, J. R.;Kim, W. G.;Han, D. S.;Park, S. H.;Hong, H.;Choi, Y.;Ahn, H. S.;Suh, Y. S.;Yang, H. K. 2018
Early Parenteral Nutrition in Patients with Biliopancreatic Mass Lesions, a Prospective, Randomized Intervention Trial Kruger, J.;Meffert, P. J.;Vogt, L. J.;Gartner, S.;Steveling, A.;Kraft, M.;Mayerle, J.;Lerch, M. M.;Aghdassi, A. A. 2016
Nutritional Support for Patients with Diseases of Hepatopancreotoduodenal Zone in the Early After the Operational Period Kurbanalievich, Sherzad Davanov;Vladimirovich, Dmitry Vasiliev;Kabildina, Nailya Amirbekovna 2020
Impact of Preoperative Immunonutrition on the Outcomes of Colon Cancer Surgery: Results from a Randomized Controlled Trial Lee, S. Y.;Lee, J.;Park, H. M.;Kim, C. H.;Kim, H. R. 2021
Influence of pre-operative oral carbohydrate loading vs. standard fasting on tumor proliferation and clinical outcome in breast cancer patients horizontal line a randomized trial Lende, T. H.;Austdal, M.;Varhaugvik, A. E.;Skaland, I.;Gudlaugsson, E.;Kvaloy, J. T.;Akslen, L. A.;Soiland, H.;Janssen, E. A. M.;Baak, J. P. A. 2019
The postoperative clinical outcomes and safety of early enteral nutrition in operated gastric cancer patients Li, B.;Liu, H. Y.;Guo, S. H.;Sun, P.;Gong, F. M.;Jia, B. Q. 2015
Impact of early postoperative enteral nutrition on clinical outcomes in patients with gastric cancer Li, B.;Liu, H. Y.;Guo, S. H.;Sun, P.;Gong, F. M.;Jia, B. Q. 2015
Early enteral immunonutrition support protects the cellular and humoral immune functions of patients with pancreatic cancer after chemotherapy Li, C.;Ni, L.;Liu, C. 2020
A randomized placebo controlled trial of preoperative carbohydrate drinks and early postoperative nutritional supplement drinks in colorectal surgery Lidder, P.;Thomas, S.;Fleming, S.;Hosie, K.;Shaw, S.;Lewis, S. 2013
A multidisciplinary team approach for nutritional interventions conducted by specialist nurses in patients with advanced colorectal cancer undergoing chemotherapy: A clinical trial Lin, J. X.;Chen, X. W.;Chen, Z. H.;Huang, X. Y.;Yang, J. J.;Xing, Y. F.;Yin, L. H.;Li, X.;Wu, X. Y. 2017
Enteral nutrition is superior to total parenteral nutrition for pancreatic cancer patients who underwent pancreaticoduodenectomy Liu, C.;Du, Z.;Lou, C.;Wu, C.;Yuan, Q.;Wang, J.;Shu, G.;Wang, Y. 2011
Early postoperative jejunostomy feeding with an immune modulating diet in patients undergoing resectional surgery for upper gastrointestinal cancer: a prospective, randomized, controlled, double-blind study Lobo, D. N.;Williams, R. N.;Welch, N. T.;Aloysius, M. M.;Nunes, Q. M.;Padmanabhan, J.;Crowe, J. R.;Iftikhar, S. Y.;Parsons, S. L.;Neal, K. R.;Allison, S. P.;Rowlands, B. J. 2006
Head and neck cancer patients under (chemo-)radiotherapy undergoing nutritional intervention: Results from the prospective randomized HEADNUT-trial Loser, A.;Abel, J.;Kutz, L. M.;Krause, L.;Finger, A.;Greinert, F.;Sommer, M.;Lorenz, T.;Culmann, E.;von Grundherr, J.;Wegert, L.;Lehmann, L.;Matnjani, G.;Schwarz, R.;Brackrock, S.;Krull, A.;Petersen, C.;Carl, C. O. 2021
The inflammatory modulation effect of glutamine-enriched total parenteral nutrition in postoperative gastrointestinal cancer patients Lu, C. Y.;Shih, Y. L.;Sun, L. C.;Chuang, J. F.;Ma, C. J.;Chen, F. M.;Wu, D. C.;Hsieh, J. S.;Wang, J. Y. 2011
Efficacy of Early Enteral Immunonutrition on Immune Function and Clinical Outcome for Postoperative Patients With Gastrointestinal Cancer Luo, Z.;Wang, J.;Zhang, Z.;Li, H.;Huang, L.;Qiao, Y.;Wang, D.;Huang, J.;Guo, L.;Liu, J.;Liu, Y.;Zhang, Y. 2018
Effects of Enteral Nutrition on Patients With Oesophageal Carcinoma Treated With Concurrent Chemoradiotherapy: A Prospective, Multicentre, Randomised, Controlled Study Lyu, J.;Shi, A.;Li, T.;Li, J.;Zhao, R.;Zhu, S.;Wang, J.;Xing, L.;Yang, D.;Xie, C.;Shen, L.;Zhang, H.;Zhu, G.;Wang, J.;Pan, W.;Li, F.;Lang, J.;Shi, H. 2022
Effect of postoperative early enteral nutrition on clinical outcomes and immune function of cholangiocarcinoma patients with malignant obstructive jaundice Ma, B. Q.;Chen, S. Y.;Jiang, Z. B.;Wu, B.;He, Y.;Wang, X. X.;Li, Y.;Gao, P.;Yang, X. J. 2020
Early initiation of oral feeding following upper gastrointestinal tumor surgery: a randomized controlled trial Mahmoodzadeh, H.;Shoar, S.;Sirati, F.;Khorgami, Z. 2015
Efficacy of preoperative immunonutrition in locally advanced pancreatic cancer undergoing irreversible electroporation (IRE) Martin, R. C., 2nd;Agle, S.;Schlegel, M.;Hayat, T.;Scoggins, C. R.;McMasters, K. M.;Philips, P. 2017
Enteral Diet Enriched with omega-3 Fatty Acid Improves Oxygenation After Thoracic Esophagectomy for Cancer: A Randomized Controlled Trial Matsuda, Y.;Habu, D.;Lee, S.;Kishida, S.;Osugi, H. 2017
Clinical trial: normal diet vs. partial replacement with oral E028 formula for the prevention of gastrointestinal toxicity in cancer patients undergoing pelvic radiotherapy McGough, C.;Wedlake, L.;Baldwin, C.;Hackett, C.;Norman, A. R.;Blake, P.;Harrington, K.;Tait, D.;Khoo, V.;Frost, G.;Andreyev, H. J. 2008
Post-discharge oral nutritional supplements with dietary advice in patients at nutritional risk after surgery for gastric cancer: A randomized clinical trial Meng, Q.;Tan, S.;Jiang, Y.;Han, J.;Xi, Q.;Zhuang, Q.;Wu, G. 2021
Reduction of postoperative complication rate with the use of early oral feeding in gynecologic oncologic patients undergoing a major surgery: a randomized controlled trial Minig, L.;Biffi, R.;Zanagnolo, V.;Attanasio, A.;Beltrami, C.;Bocciolone, L.;Botteri, E.;Colombo, N.;Iodice, S.;Landoni, F.;Peiretti, M.;Roviglione, G.;Maggioni, A. 2009
Effects of Early Initiation of Solid Versus Liquid Diet after Endoscopic Submucosal Dissection on Quality of Life and Postoperative Outcomes: A Prospective Pilot Randomized Controlled Trial Miyakawa, A.;Kodera, S.;Sakuma, Y.;Shimada, T.;Kubota, M.;Nakamura, A.;Itobayashi, E.;Shimura, H.;Suzuki, Y.;Sato, Y.;Shimura, K. 2019
Randomized study of clinical effect of enteral nutrition support during neoadjuvant chemotherapy on chemotherapy-related toxicity in patients with esophageal cancer Miyata, H.;Yano, M.;Yasuda, T.;Hamano, R.;Yamasaki, M.;Hou, E.;Motoori, M.;Shiraishi, O.;Tanaka, K.;Mori, M.;Doki, Y. 2012
Randomized study of the clinical effects of omega-3 fatty acid-containing enteral nutrition support during neoadjuvant chemotherapy on chemotherapy-related toxicity in patients with esophageal cancer Miyata, H.;Yano, M.;Yasuda, T.;Yamasaki, M.;Murakami, K.;Makino, T.;Nishiki, K.;Sugimura, K.;Motoori, M.;Shiraishi, O.;Mori, M.;Doki, Y. 2017
Effects of medical nutrition therapy compared with general nutritional advice on nutritional status and nutrition-related complications in esophageal cancer patients receiving concurrent chemoradiation: A randomized controlled trial Movahed, Sara;Seilanian Toussi, Mehdi;Pahlavani, Naseh;Motlagh, Ali Ghanbari;Eslami, Saeid;Nematy, Mohsen;Ghayour-Mobarhan, Majid;Khadem-Rezaiyan, Majid;Emadzadeh, Maryam;Varshoee Tabrizi, Fatemeh;Bozzetti, Federico;Norouzy, Abdolreza 2020
Perioperative immunonutrition in normo-nourished patients undergoing laparoscopic colorectal resection Moya, P.;Miranda, E.;Soriano-Irigaray, L.;Arroyo, A.;Aguilar, M. D.;Bellon, M.;Munoz, J. L.;Candela, F.;Calpena, R. 2016
Multicentre factorial randomized clinical trial of perioperative immunonutrition versus standard nutrition for patients undergoing surgical resection of oesophageal cancer Mudge, L. A.;Watson, D. I.;Smithers, B. M.;Isenring, E. A.;Smith, L.;Jamieson, G. G.;Australian Immunonutrition Study, Group 2018
Randomized Study of the Effect of Dietary Counseling During Adjuvant Chemotherapy on Chemotherapy Induced Nausea and Vomiting, and Quality of Life in Patients With Breast Cancer Najafi, S.;Haghighat, S.;Raji Lahiji, M.;RazmPoosh, E.;Chamari, M.;Abdollahi, R.;Asgari, M.;Zarrati, M. 2019
Early enteral nutrition support for colon carcinoma patients can improve immune function and promote physical recovery Nie, J.;Su, X.;Wei, L.;Li, H. 2021
L-alanin-L-glutamine supplementation improves the outcome after colorectal surgery for cancer Oguz, M.;Kerem, M.;Bedirli, A.;Mentes, B. B.;Sakrak, O.;Salman, B.;Bostanci, H. 2007
Randomized controlled trial on efficacy of oligomeric formula (HINE E-GEL(R)) versus polymeric formula (MEIN(R)) enteral nutrition after esophagectomy for esophageal cancer with gastric tube reconstruction Ohkura, Y.;Ueno, M.;Shindoh, J.;Iizuka, T.;Udagawa, H. 2019
Oral supplementation with carbohydrate- and branched-chain amino acid-enriched nutrients improves postoperative quality of life in patients undergoing hepatic resection Okabayashi, T.;Iyoki, M.;Sugimoto, T.;Kobayashi, M.;Hanazaki, K. 2011
Nutritional Counseling for Head and Neck Cancer Patients Undergoing (Chemo) Radiotherapy-A Prospective Randomized Trial Orell, H.;Schwab, U.;Saarilahti, K.;Osterlund, P.;Ravasco, P.;Makitie, A. 2019
A Randomized Controlled Trial to Evaluate the Role and Efficacy of Oral Glutamine in the Treatment of Chemo-radiotherapy-induced Oral Mucositis and Dysphagia in Patients with Oropharynx and Larynx Carcinoma Pathak, S.;Soni, T. P.;Sharma, L. M.;Patni, N.;Gupta, A. K. 2019
Early Enteral Versus Total Parenteral Nutrition in Patients Undergoing Pancreaticoduodenectomy: A Randomized Multicenter Controlled Trial (Nutri-DPC) Perinel, J.;Mariette, C.;Dousset, B.;Sielezneff, I.;Gainant, A.;Mabrut, J. Y.;Bin-Dorel, S.;Bechwaty, M. E.;Delaunay, D.;Bernard, L.;Sauvanet, A.;Pocard, M.;Buc, E.;Adham, M. 2016
Effects of a dietary intervention on acute gastrointestinal side effects and other aspects of health-related quality of life: a randomized controlled trial in prostate cancer patients undergoing radiotherapy Pettersson, A.;Johansson, B.;Persson, C.;Berglund, A.;Turesson, I. 2012
Effects of a dietary intervention on gastrointestinal symptoms after prostate cancer radiotherapy: long-term results from a randomized controlled trial Pettersson, A.;Nygren, P.;Persson, C.;Berglund, A.;Turesson, I.;Johansson, B. 2014
Long-term oral branched chain amino acids in patients undergoing chemoembolization for hepatocellular carcinoma: a randomized trial Poon, R. T.;Yu, W. C.;Fan, S. T.;Wong, J. 2004
Echium oil is not protective against weight loss in head and neck cancer patients undergoing curative radio(chemo)therapy: a randomised-controlled trial Pottel, L.;Lycke, M.;Boterberg, T.;Pottel, H.;Goethals, L.;Duprez, F.;Maes, A.;Goemaere, S.;Rottey, S.;Foubert, I.;Debruyne, P. R. 2014
Randomized trial of the effects of individual nutritional counseling in cancer patients Poulsen, G. M.;Pedersen, L. L.;Osterlind, K.;Baeksgaard, L.;Andersen, J. R. 2014
The Effect of Nutrition Intervention With Oral Nutritional Supplements on Ovarian Cancer Patients Undergoing Chemotherapy Qin, N.;Jiang, G.;Zhang, X.;Sun, D.;Liu, M. 2021
Effect of whole-course nutrition management on patients with esophageal cancer undergoing concurrent chemoradiotherapy: A randomized control trial Qiu, Y.;You, J.;Wang, K.;Cao, Y.;Hu, Y.;Zhang, H.;Fu, R.;Sun, Y.;Chen, H.;Yuan, L.;Lyu, Q. 2020
Impact of nutrition on outcome: a prospective randomized controlled trial in patients with head and neck cancer undergoing radiotherapy Ravasco, P.;Monteiro-Grillo, I.;Marques Vidal, P.;Camilo, M. E. 2005
Individualized nutrition intervention is of major benefit to colorectal cancer patients: long-term follow-up of a randomized controlled trial of nutritional therapy Ravasco, P.;Monteiro-Grillo, I.;Camilo, M. 2012
Protein intake, weight loss, dietary intervention, and worsening of quality of life in older patients during chemotherapy for cancer Regueme, S. C.;Echeverria, I.;Moneger, N.;Durrieu, J.;Becerro-Hallard, M.;Duc, S.;Lafargue, A.;Mertens, C.;Laksir, H.;Ceccaldi, J.;Lavau-Denes, S.;Dantoine, T.;Irazusta, J.;Bourdel-Marchasson, I. 2021
Perioperative Oral Nutrition Supplementation Reduces Prevalence of Sarcopenia following Radical Cystectomy: Results of a Prospective Randomized Controlled Trial Ritch, C. R.;Cookson, M. S.;Clark, P. E.;Chang, S. S.;Fakhoury, K.;Ralls, V.;Thu, M. H.;Penson, D. F.;Smith, J. A., Jr.;Silver, H. J. 2019
A randomised controlled study of preoperative oral carbohydrate loading versus fasting in patients undergoing colorectal surgery Rizvanovic, N.;Nesek Adam, V.;Causevic, S.;Dervisevic, S.;Delibegovic, S. 2019
Total parenteral nutrition vs oral diet in autologous hematopoietic cell transplant recipients Roberts, S.;Miller, J.;Pineiro, L.;Jennings, L. 2003
Enteral nutrition enriched with eicosapentaenoic acid (EPA) preserves lean body mass following esophageal cancer surgery: results of a double-blinded randomized controlled trial Ryan, A. M.;Reynolds, J. V.;Healy, L.;Byrne, M.;Moore, J.;Brannelly, N.;McHugh, A.;McCormack, D.;Flood, P. 2009
Clinical outcomes comparing parenteral and nasogastric tube nutrition after laryngeal and pharyngeal cancer surgery Ryu, J.;Nam, B. H.;Jung, Y. S. 2009
Nasogastric and percutaneous endoscopic gastrostomy tube use in advanced head and neck cancer patients: a comparative study Sadasivan, A.;Faizal, B.;Kumar, M. 2012
Effect of Early Peripheral Parenteral Nutrition Support in an Enhanced Recovery Program for Colorectal Cancer Surgery: A Randomized Open Trial Sanchez-Guillen, L.;Soriano-Irigaray, L.;Lopez-Rodriguez-Arias, F.;Barber, X.;Murcia, A.;Alcaide, M. J.;Aranaz-Ostariz, V.;Soler-Silva, A.;Navarro-Ruiz, A.;Arroyo, A. 2021
Effects of an oral nutritional supplement containing eicosapentaenoic acid on nutritional and clinical outcomes in patients with advanced non-small cell lung cancer: randomised trial Sanchez-Lara, K.;Turcott, J. G.;Juarez-Hernandez, E.;Nunez-Valencia, C.;Villanueva, G.;Guevara, P.;De la Torre-Vallejo, M.;Mohar, A.;Arrieta, O. 2014
The Impact of Postoperative Enteral Immunonutrition on Postoperative Complications and Survival in Gastric Cancer Patients - Randomized Clinical Trial Scislo, L.;Pach, R.;Nowak, A.;Walewska, E.;Gadek, M.;Brandt, P.;Puto, G.;Szczepanik, A. M.;Kulig, J. 2018
Perioperative optimization with nutritional supplements in patients undergoing gastrointestinal surgery for cancer: A randomized, placebo-controlled feasibility clinical trial Serrano, P. E.;Parpia, S.;Simunovic, M.;Duceppe, E.;Pinto-Sanchez, M. I.;Bhandari, M.;Levine, M. 2022
A randomized controlled trial of early oral feeding in laryngectomized patients Seven, H.;Calis, A. B.;Turgut, S. 2003
Clinical Application of Enteral Nutrition Combined with Microbial Preparation for Intestinal Preparation in Elderly Patients with Colorectal Cancer Shen, Y.;Zhao, X.;Zhao, H.;Chen, N.;Wang, J.;Zhuang, H.;Zhang, X. 2022
Effect of early oral feeding on length of hospital stay following gastrectomy for gastric cancer: a Japanese multicenter, randomized controlled trial Shimizu, N.;Oki, E.;Tanizawa, Y.;Suzuki, Y.;Aikou, S.;Kunisaki, C.;Tsuchiya, T.;Fukushima, R.;Doki, Y.;Natsugoe, S.;Nishida, Y.;Morita, M.;Hirabayashi, N.;Hatao, F.;Takahashi, I.;Choda, Y.;Iwasaki, Y.;Seto, Y. 2018
Impact of prophylactic percutaneous endoscopic gastrostomy on malnutrition and quality of life in patients with head and neck cancer: a randomized study Silander, E.;Nyman, J.;Bove, M.;Johansson, L.;Larsson, S.;Hammerlid, E. 2012
The Effect of Omega-3 Enriched Oral Nutrition Supplement on Nutritional Indices and Quality of Life in Gastrointestinal Cancer Patients: A Randomized Clinical Trial Sim, E.;Kim, J. M.;Lee, S. M.;Chung, M. J.;Song, S. Y.;Kim, E. S.;Chun, H. J.;Sung, M. K. 2022
Effect of a perioperative immune-enhancing diet in clean-contaminated head and neck cancer surgery: A randomized controlled trial Sittitrai, P.;Ruenmarkkaew, D.;Booyaprapa, S.;Kasempitakpong, B. 2021
Body weight, body composition and survival after 1 year: follow-up of a nutritional intervention trial in allo-HSCT recipients Skaarud, K. J.;Veierod, M. B.;Lergenmuller, S.;Bye, A.;Iversen, P. O.;Tjonnfjord, G. E. 2019
Effect of Hospital to Home nutrition management model on postoperative clinical outcomes of patients with laryngeal carcinoma Song, G.;Liu, H. 2017
Randomized clinical trial of perioperative omega-3 fatty acid supplements in elective colorectal cancer surgery Sorensen, L. S.;Thorlacius-Ussing, O.;Schmidt, E. B.;Rasmussen, H. H.;Lundbye-Christensen, S.;Calder, P. C.;Lindorff-Larsen, K. 2014
Does early oral feeding increase the likelihood of salivary fistula after total laryngectomy? Sousa, A. A.;Porcaro-Salles, J. M.;Soares, J. M.;de Moraes, G. M.;Silva, G. S.;Sepulcri, R. A.;Savassi-Rocha, P. R. 2014
Randomized clinical trial of omega-3 fatty acid-supplemented enteral nutrition versus standard enteral nutrition in patients undergoing oesophagogastric cancer surgery Sultan, J.;Griffin, S. M.;Di Franco, F.;Kirby, J. A.;Shenton, B. K.;Seal, C. J.;Davis, P.;Viswanath, Y. K.;Preston, S. R.;Hayes, N. 2012
Early Oral Feeding Following McKeown Minimally Invasive Esophagectomy: An Open-label, Randomized, Controlled, Noninferiority Trial Sun, H. B.;Li, Y.;Liu, X. B.;Zhang, R. X.;Wang, Z. F.;Lerut, T.;Liu, C. C.;Fiorelli, A.;Chao, Y. K.;Molena, D.;Cerfolio, R. J.;Ozawa, S.;Chang, A. C.;written on behalf of the, A. M. E. Thoracic Surgery Collaborative Group 2018
Randomized, controlled study of branched chain amino acid-enriched total parenteral nutrition in malnourished patients with gastrointestinal cancer undergoing surgery Sun, L. C.;Shih, Y. L.;Lu, C. Y.;Hsieh, J. S.;Chuang, J. F.;Chen, F. M.;Ma, C. J.;Wang, J. Y. 2008
A snack enriched with oral branched-chain amino acids prevents a fall in albumin in patients with liver cirrhosis undergoing chemoembolization for hepatocellular carcinoma Takeshita, S.;Ichikawa, T.;Nakao, K.;Miyaaki, H.;Shibata, H.;Matsuzaki, T.;Muraoka, T.;Honda, T.;Otani, M.;Akiyama, M.;Miuma, S.;Ozawa, E.;Fujimito, M.;Eguchi, K. 2009
New perspective on the nutritional approach to cancer-related anorexia/cachexia: preliminary results of a randomised phase III clinical trial with five different arms of treatment Tanca, Francesca Maria;Madeddu, Clelia;Macci, Antonio;Serpe, Roberto;Panzone, Filomena;Antoni, Giorgia;Massa, Elena;Astara, Giorgio;Mantovani, Giovanni 2009
A Prospective Randomized Trial Comparing Jejunostomy and Nasogastric Feeding in Minimally Invasive McKeown Esophagectomy Tao, Z.;Zhang, Y.;Zhu, S.;Ni, Z.;You, Q.;Sun, X.;Xu, D. 2020
Preoperative nutritional support for patients undergoing elective colorectal cancer surgery - does it really work? Tesar, M.;Kozusnikova, V.;Martinek, L.;Durdik, S.;Ihnat, P. 2022
Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients Tsuchiya, T.;Honda, H.;Oikawa, M.;Kakita, T.;Oyama, A.;Oishi, H.;Tochikubo, K.;Hashimoto, T.;Kurihara, S.;Shibakusa, T.;Kayahara, T. 2016
Effects of an intervention on nutrition consultation for cancer patients Tu, M. Y.;Chien, T. W.;Lin, H. P.;Liu, M. Y. 2013
Nutritional and immune impairments and their effects on outcomes in early pancreatic cancer patients undergoing pancreatoduodenectomy Tumas, J.;Tumiene, B.;Jurkeviciene, J.;Jasiunas, E.;Sileikis, A. 2020
Intensive nutritional counseling improves PG-SGA scores and nutritional symptoms during and after radiotherapy in Korean cancer patients Um, M. H.;Choi, M. Y.;Lee, S. M.;Lee, I. J.;Lee, C. G.;Park, Y. K. 2014
Influence of a nutritional intervention on dietary intake and quality of life in cancer patients: a randomized controlled trial Uster, A.;Ruefenacht, U.;Ruehlin, M.;Pless, M.;Siano, M.;Haefner, M.;Imoberdorf, R.;Ballmer, P. E. 2013
Calorie restriction and synbiotics effect on quality of life and edema reduction in breast cancer-related lymphedema, a clinical trial Vafa, S.;Zarrati, M.;Malakootinejad, M.;Totmaj, A. S.;Zayeri, F.;Salehi, M.;Sanati, V.;Haghighat, S. 2020
Beneficial Effects of Early Enteral Nutrition After Major Rectal Surgery: A Possible Role for Conditionally Essential Amino Acids? Results of a Randomized Clinical Trial van Barneveld, K. W.;Smeets, B. J.;Heesakkers, F. F.;Bosmans, J. W.;Luyer, M. D.;Wasowicz, D.;Bakker, J. A.;Roos, A. N.;Rutten, H. J.;Bouvy, N. D.;Boelens, P. G. 2016
The effect of nutritional counseling on muscle mass and treatment outcome in patients with metastatic colorectal cancer undergoing chemotherapy: A randomized controlled trial van der Werf, A.;Langius, J. A. E.;Beeker, A.;Ten Tije, A. J.;Vulink, A. J.;Haringhuizen, A.;Berkhof, J.;van der Vliet, H. J.;Verheul, H. M. W.;de van der Schueren, M. A. E. 2020
Oncological and functional outcomes of postoperative total parenteral nutrition after radical cystectomy in bladder cancer patients: A single-center randomized trial Vidal, A.;Arnold, N.;Vartolomei, M. D.;Kiss, B.;Burkhard, F.;Thalmann, G. N.;Roth, B. 2016
Efficacy of glutamine in the prevention of acute radiation enteritis: a randomized controlled trial Vidal-Casariego, A.;Calleja-Fernandez, A.;de Urbina-Gonzalez, J. J.;Cano-Rodriguez, I.;Cordido, F.;Ballesteros-Pomar, M. D. 2014
Preventing weight gain during adjuvant chemotherapy for breast cancer: a dietary intervention study Villarini, A.;Pasanisi, P.;Raimondi, M.;Gargano, G.;Bruno, E.;Morelli, D.;Evangelista, A.;Curtosi, P.;Berrino, F. 2012
ERGO2: A Prospective, Randomized Trial of Calorie-Restricted Ketogenic Diet and Fasting in Addition to Reirradiation for Malignant Glioma Voss, M.;Wagner, M.;von Mettenheim, N.;Harter, P. N.;Wenger, K. J.;Franz, K.;Bojunga, J.;Vetter, M.;Gerlach, R.;Glatzel, M.;Paulsen, F.;Hattingen, E.;Baehr, O.;Ronellenfitsch, M. W.;Fokas, E.;Imhoff, D.;Steinbach, J. P.;Rodel, C.;Rieger, J. 2020
Impact of enteral nutrition on postoperative immune function and nutritional status Wang, F.;Hou, M. X.;Wu, X. L.;Bao, L. D.;Dong, P. D. 2015
Effect of glutamine-enriched nutritional support on intestinal mucosal barrier function, MMP-2, MMP-9 and immune function in patients with advanced gastric cancer during perioperative chemotherapy Wang, J.;Li, Y.;Qi, Y. 2017
Effect of Early Enteral Nutrition Support Combined with Chemotherapy on Related Complications and Immune Function of Patients after Radical Gastrectomy Wang, J.;Wang, L.;Zhao, M.;Zuo, X.;Zhu, W.;Cui, K.;Yan, X.;Liu, X. 2022
Early enteral nutrition and total parenteral nutrition on the nutritional status and blood glucose in patients with gastric cancer complicated with diabetes mellitus after radical gastrectomy Wang, J.;Zhao, J.;Zhang, Y.;Liu, C. 2018
Safety of early oral feeding after total laparoscopic radical gastrectomy for gastric cancer (SOFTLY-1): a single-center randomized controlled trial Wang, Q.;Yang, K. L.;Guo, B. Y.;Shang, L. F.;Yan, Z. D.;Yu, J.;Zhang, D.;Ji, G. 2019
Effects of lipid emulsions in parenteral nutrition of esophageal cancer surgical patients receiving enteral nutrition: a comparative analysis Wang, W. P.;Yan, X. L.;Ni, Y. F.;Guo, K.;Ke, C. K.;Cheng, Q. S.;Lu, Q.;Zhang, L. J.;Li, X. F. 2013
Enteral nutrition improves clinical outcome and shortens hospital stay after cancer surgery Wang, X.;Pan, L.;Zhang, P.;Liu, X.;Wu, G.;Wang, Y.;Liu, Y.;Li, N.;Li, J. 2010
Clinical trial: Efficacy of a low or modified fat diet for the prevention of gastrointestinal toxicity in patients receiving radiotherapy treatment for pelvic malignancies Wedlake, L. J.;McGough, C.;Shaw, C.;Klopper, T.;Thomas, K.;Lalji, A.;Dearnaley, D. P.;Blake, P.;Tait, D.;Khoo, V. S.;Andreyev, H. J. 2012
Effects of Perioperative Oral Nutrition Supplementation in Malaysian Patients Undergoing Elective Surgery for Breast and Colorectal Cancers-A Randomised Controlled Trial Wong, T. X.;Wong, W. X.;Chen, S. T.;Ong, S. H.;Shyam, S.;Ahmed, N.;Hamdan, K. H.;Awang, R. R.;Ibrahim, M. R.;Palayan, K.;Chee, W. S. S. 2022
Perioperative artificial nutrition in malnourished gastrointestinal cancer patients Wu, G. H.;Liu, Z. H.;Wu, Z. H.;Wu, Z. G. 2006
Effect of enteral nutrition support on the curative effect and immune system in patients with rectal cancer during fast track surgery Wu, S.;You, D.;Lu, L.;Tong, Y.;Hu, Q.;Jin, T.;Wang, Y. 2020
Effect of Early Full-Calorie Nutrition Support Following Esophagectomy: A Randomized Controlled Trial Wu, W.;Zhong, M.;Zhu, D. M.;Song, J. Q.;Huang, J. F.;Wang, Q.;Tan, L. J. 2017
Omega-3 fatty acid improves the clinical outcome of hepatectomized patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma Wu, Z.;Qin, J.;Pu, L. 2012
Efficacy of early postoperative enteral nutrition in supporting patients after esophagectomy Xiao-Bo, Y.;Qiang, L.;Xiong, Q.;Zheng, R.;Jian, Z.;Jian-Hua, Z.;Qian-Jun, Z. 2014
Beneficial Effect of Educational and Nutritional Intervention on the Nutritional Status and Compliance of Gastric Cancer Patients Undergoing Chemotherapy: A Randomized Trial Xie, F. L.;Wang, Y. Q.;Peng, L. F.;Lin, F. Y.;He, Y. L.;Jiang, Z. Q. 2017
A randomized controlled trial of oral nutritional supplementation versus standard diet following McKeown minimally invasive esophagectomy in patients with esophageal malignancy: a pilot study Xie, H.;Chen, X.;Xu, L.;Zhang, R.;Kang, X.;Wei, X.;Yang, Y.;Li, Y. 2021
The effect of early enteral nutrition on the postoperative immune function and inflammatory indexes in patients with digestive tract cancers Xu, B.;Ma, J.;Chen, X.;Zhang, S. 2020
Preoperative enteral immunonutrition improves postoperative outcome in patients with gastrointestinal cancer Xu, J.;Zhong, Y.;Jing, D.;Wu, Z. 2006
The Effects of Early Post-Operative Soluble Dietary Fiber Enteral Nutrition for Colon Cancer Xu, R.;Ding, Z.;Zhao, P.;Tang, L.;Tang, X.;Xiao, S. 2016
Perioperative Enteral Nutrition Improves Postoperative Recovery for Patients with Primary Liver Cancer: A Randomized Controlled Clinical Trial Yan, X.;Liu, L.;Zhang, Y.;Song, T.;Liang, Y.;Liu, Z.;Bao, X.;Mao, L.;Qiu, Y. 2021
Effects of EN combined with PN enriched with n-3 polyunsaturated fatty acids on immune related indicators and early rehabilitation of patients with gastric cancer: A randomized controlled trial Yang, J.;Zhang, X.;Li, K.;Zhou, Y.;Hu, Y.;Chen, X.;Liang, S.;Jiang, L. 2022
Effect of Oral Nutritional Supplements on Patients with Esophageal Cancer During Radiotherapy Yang, L.;Gao, J.;Zhou, Y.;Tao, Z.;He, J.;Yang, J.;Wang, R.;Zhang, Y.;Huang, Y.;Zhou, L.;Sun, B. 2020
Effects of postoperative enteral nutrition combined with adjuvant radiotherapy on inflammatory response, nutrition, healing and prognosis in patients receiving radical surgery for esophageal carcinoma Yao, R.;Zhang, T.;Zhang, J.;Sun, Y.;Xu, L.;Zhang, D.;Zhou, L. 2019
Comparison of Perioperative Standard and Immunomodulating Enteral Nutrition in Patients Received Major Abdominal Cancer Surgery: a Prospective, Randomized, Controlled Clinical Trial Yeen, S. F.;Kafadar, M. T.;Gk, M. A. 2020
Omega-3 fatty acid-, micronutrient-, and probiotic-enriched nutrition helps body weight stabilization in head and neck cancer cachexia Yeh, K. Y.;Wang, H. M.;Chang, J. W.;Huang, J. S.;Lai, C. H.;Lan, Y. J.;Wu, T. H.;Chang, P. H.;Wang, H.;Wu, C. J.;Hsia, S.;Wang, C. H. 2013
n-3 fatty acid-based parenteral nutrition improves postoperative recovery for cirrhotic patients with liver cancer: A randomized controlled clinical trial Zhang, B.;Wei, G.;Li, R.;Wang, Y.;Yu, J.;Wang, R.;Xiao, H.;Wu, C.;Leng, C.;Zhang, B.;Chen, X. P. 2017
Effect of peripherally inserted central catheter (PICC) parenteral nutrition on immune function and nutritional support after radical gastrectomy for gastric cancer Zhang, J.;Si, X.;Li, W.;Yang, J.;Cao, Y. 2019
Effectiveness of Noninvasive Positive Pressure Ventilation Combined with Enteral Nutrition in the Treatment of Patients with Combined Respiratory Failure after Lung Cancer Surgery and Its Effect on Blood Gas Indexes Zhang, Y.;Liu, L.;Li, D.;Zhou, D. 2022
Nutritional education and counseling program for adult cancer patients during radiotherapy: a cluster-randomized clinical trial Zhang, Z.;Zhu, Y.;Zhang, L.;Wang, Z.;Fu, Z.;Chen, G.;Xiang, L.;Wan, H. 2022
Application of enteral nutrition during perichemotherapy of acute non-lymphocytic leukemia Zhao, M.;Li, X. G.;Ma, Y. Y.;Liu, Y.;Wang, L. X.;Shen, J. L.;Zhu, Z. M. 2014
Effects of Preoperative Enteral Nutrition on Postoperative Recent Nutritional Status in Patients with Siewert II and III Adenocarcinoma of Esophagogastric Junction after Neoadjuvant Chemoradiotherapy Zhao, Q.;Li, Y.;Yu, B.;Yang, P.;Fan, L.;Tan, B.;Tian, Y. 2018
Impact of fish oil enriched total parenteral nutrition on elderly patients after colorectal cancer surgery Zhu, M. W.;Tang, D. N.;Hou, J.;Wei, J. M.;Hua, B.;Sun, J. H.;Cui, H. Y. 2012
Effect of oral nutritional supplementation on the post-discharge nutritional status and quality of life of gastrointestinal cancer patients after surgery: a multi-center study Zhu, M. W.;Yang, X.;Xiu, D. R.;Yang, Y.;Li, G. X.;Hu, W. G.;Wang, Z. G.;Cui, H. Y.;Wei, J. M. 2019
Chemotherapy-Related Toxicity, Nutritional Status and Quality of Life in Precachectic Oncologic Patients with, or without, High Protein Nutritional Support. A Prospective, Randomized Study Zietarska, M.;Krawczyk-Lipiec, J.;Kraj, L.;Zaucha, R.;Malgorzewicz, S. 2017
Effects of preoperative oral single-dose and double-dose carbohydrates on insulin resistance in patients undergoing gastrectomy:a prospective randomized controlled trial Chen, Xinrong, Li, Ka, Yang, Kun, Hu, Jiankun, Yang, Jie, Feng, Jinhua, Hu, Yanjie, Zhang, Xingxia 2021
Perioperative Total Parenteral Nutrition in Malnourished, Gastrointestinal Cancer Patients: A Randomized, Clinical Trial Bozzetti, Federico, Gavazzi, Cecilia, Miceli, Rosalba, Rossi, Nicoletta, Mariani, Luigi, Cozzaglio, Luca, Bonfanti, Giuliano, Piacenza, Sabrina 2000
Quality of life and illness perceptions in patients with breast cancer using a fasting mimicking diet as an adjunct to neoadjuvant chemotherapy in the phase 2 DIRECT (BOOG 201314) trial Lugtenberg, Rieneke T., de Groot, Stefanie, Kaptein, Ad A., Fischer, Maarten J., Kranenbarg, Elma Meershoek-Klein, Carpentier, Marjolijn Duijm-de, Cohen, Danielle, de Graaf, Hiltje, Heijns, Joan B., Portielje, Johanneke E. A., van de Wouw, Agnes J., Imholz, Alex L. T., Kessels, Lonneke W., Vrijaldenhoven, Suzan, Baars, Arnold, Fiocco, Marta, van der Hoeven, Jacobus J. M., Gelderblom, Hans, Longo, Valter D., Pijl, Hanno, Kroep, Judith R. 2021
Postoperative enteral versus parenteral nutrition in malnourished patients with gastrointestinal cancer: a randomised multicentre trial Bozzetti, F, Braga, M, Gianotti, L, Gavazzi, C, Mariani, L 2001
Early postoperative enteral nutrition improves gut oxygenation and reduces costs compared with total parenteral nutrition Braga, Marco, Gianotti, Luca, Gentilini, Oreste, Parisi, Valeria, Salis, Carlo, Di Carlo, Valerio 2001
A Prospective Randomized Trial of the Effects of Early Enteral Feeding After Radical Cystectomy Deibert, Christopher M, Silva, Mark V, RoyChoudhury, Arindam, McKiernan, James M, Scherr, Douglas S, Seres, David, Benson, Mitchell C 2016
Oral nutritional supplements versus a regular diet alone for body weight loss after gastrectomy: a phase 3, multicenter, open-label randomized controlled trial Miyazaki, Yasuhiro, Omori, Takeshi, Fujitani, Kazumasa, Fujita, Junya, Kawabata, Ryohei, Imamura, Hiroshi, Okada, Kazuyuki, Moon, Jeong-Ho, Hirao, Motohiro, Matsuyama, Jin, Saito, Takuro, Takahashi, Tsuyoshi, Kurokawa, Yukinori, Yamasaki, Makoto, Takiguchi, Shuji, Mori, Masaki, Doki, Yuichiro 2021

Downloadable Data Content

  • XLSX Project Data