Extraction form for project: Acute Pain Updates

Design Details

1. Setting
Column B
2. Country
Column C
3. Specific Pain Condition
Column D
4. Intervention Types Compared
Column E
5. Number randomized
Total
Intervention A
Intervention B
6. Number Analyzed
Total
Intervention A
Intervention B
7. Participants age (mean, years)
8. Participants sex (% Female)
9. Race (%)
Column L
10. History of Substance Use Disorder
Column N
11. Under Treatment for Opiate Use Disorder
Column O
12. History of Psychiatric Illness
Column P
13. Pregnant or Breastfeeding
Column R
14. Pain Duration
Column R
15. Overall Baseline Pain Standardized Scale 0 to 10
Column S
16. Treatment duration
Column T
17. Assessment Time Points
Column V
18. Duration of Followup Category
Column W

Arms

Arm NameArm Description
Intervention A Topical ibuprofen (5%; cream) 3 times per day for 3 days
Intervention BTopical capsaicin (0.5%; cream) 3 times per day for 3 days

Arm Details

N/A

Sample Characteristics

N/A

Outcomes

TypeDomainSpecific measurement (i.e., tool/definition/specific outcome)PopulationsTimepoints
ContinuousPainMean (SD), 0 to 10 VAS
  • All Participants
  • 24 hours (h)
  • 2 hours (h)
  • 72 hours (h)
CategoricalPain Pain reduced by >50% at 72 hours
  • All Participants
  • 72 hours (h)
CategoricalAdverse EventsAny adverse event
  • All Participants
  • After Treatment
CategoricalAdverse EventsNausea
  • All Participants
  • After Treatment
CategoricalAdverse EventsDyspepsia
  • All Participants
  • After Treatment

Outcome Details

N/A

Risk of Bias Assessment

1. Was randomization adequate?
2. Was allocation concealment adequate?
3. Were the groups similar at baseline?
4. Were the outcome assessor masked?
5. Were the care providers masked?
6. Was the patient masked?
7. Did the article report attrition, crossovers, adherence and/or contamination?
8. Loss to followup?
Differential
High
9. Was there intention-to-treat analysis?
10. Were there post-randomization exclusions?
11. Were the outcomes prespecified?
12. Quality rating

Results

Categorical


Pain (Pain reduced by >50% at 72 hours)

All Participants
Descriptive StatisticsBetween Arm Comparisons
Intervention A Intervention B
Intervention A (Topical...)
vs.
Intervention B (Topical...)
72 hours (h)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
95% CI high (RR)
Within Arm ComparisonsNet Comparisons
Intervention A Intervention B
Intervention A (Topical...)
vs.
Intervention B (Topical...)

Adverse Events (Any adverse event)

All Participants
Descriptive StatisticsBetween Arm Comparisons
Intervention A Intervention B
Intervention A (Topical...)
vs.
Intervention B (Topical...)
After Treatment
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
95% CI high (RR)
Within Arm ComparisonsNet Comparisons
Intervention A Intervention B
Intervention A (Topical...)
vs.
Intervention B (Topical...)

Adverse Events (Nausea)

All Participants
Descriptive StatisticsBetween Arm Comparisons
Intervention A Intervention B
After Treatment
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
95% CI high (OR)
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
Intervention A Intervention B

Adverse Events (Dyspepsia)

All Participants
Descriptive StatisticsBetween Arm Comparisons
Intervention A Intervention B
After Treatment
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
95% CI high (OR)
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
Intervention A Intervention B

Continuous


Pain (Mean (SD), 0 to 10 VAS)

All Participants
Descriptive StatisticsBetween Arm Comparisons
Intervention A Intervention B
24 hours (h)
Mean
Mean Difference (MD)
SD
95% CI low (MD)
95% CI high (MD)
SD (MD)
p value (MD)
2 hours (h)
Mean
Mean Difference (MD)
SD
95% CI low (MD)
95% CI high (MD)
SD (MD)
p value (MD)
72 hours (h)
Mean
Mean Difference (MD)
SD
95% CI low (MD)
95% CI high (MD)
SD (MD)
p value (MD)
Within Arm ComparisonsNet Comparisons
Intervention A Intervention B