Extraction form for project: Acute Pain Updates

Design Details

1. Setting
Column B
2. Country
Column C
3. Specific Pain Condition
Column D
4. Intervention Types Compared
Column E
5. Number randomized
Total
Intervention A
Intervention B
6. Number Analyzed
Total
Intervention A
Intervention B
7. Participants age (mean, years)
8. Participants sex (% Female)
9. Race (%)
Column L
10. History of Substance Use Disorder
Column N
11. Under Treatment for Opiate Use Disorder
Column O
12. History of Psychiatric Illness
Column P
13. Pregnant or Breastfeeding
Column R
14. Pain Duration
Column R
15. Overall Baseline Pain Standardized Scale 0 to 10
Column S
16. Treatment duration
Column T
17. Assessment Time Points
Column V
18. Duration of Followup Category
Column W

Arms

Arm NameArm Description
Intervention A Oxycodone 5 mg/acetaminophen 325 mg oral 1-2 tablets every 6 hours as needed
Intervention BAcetaminophen 650 mg oral every 6 hours (oxycodone 5 mg for breakthrough pain)

Arm Details

N/A

Sample Characteristics

N/A

Outcomes

TypeDomainSpecific measurement (i.e., tool/definition/specific outcome)PopulationsTimepoints
ContinuousPainPain intensity (mean [SD], 0 to 10 VAS)
  • All Participants
  • Day 1 after treatment
  • Day 7 after treatment
  • Day 4 after treatment
CategoricalQuality of Life and Satisfaction With Pain ReliefSatisfaction with pain relief
  • All Participants
  • After Treatment
ContinuousPersistent Opioid Use and Prescribing RatesOpioid use (mean [SD] tablets)
  • All Participants
  • After Treatment
CategoricalPersistent Opioid Use and Prescribing RatesConsumed opioids postoperatively
  • All Participants
  • After Treatment

Outcome Details

N/A

Risk of Bias Assessment

1. Was randomization adequate?
2. Was allocation concealment adequate?
3. Were the groups similar at baseline?
4. Were the outcome assessor masked?
5. Were the care providers masked?
6. Was the patient masked?
7. Did the article report attrition, crossovers, adherence and/or contamination?
8. Loss to followup?
Differential
High
9. Was there intention-to-treat analysis?
10. Were there post-randomization exclusions?
11. Were the outcomes prespecified?
12. Quality rating

Results

Categorical


Quality of Life and Satisfaction With Pain Relief (Satisfaction with pain relief)

All Participants
Descriptive StatisticsBetween Arm Comparisons
Intervention A Intervention B
After Treatment
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
Intervention A Intervention B

Persistent Opioid Use and Prescribing Rates (Consumed opioids postoperatively)

All Participants
Descriptive StatisticsBetween Arm Comparisons
Intervention A Intervention B
After Treatment
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
Intervention A Intervention B

Continuous


Pain (Pain intensity (mean [SD], 0 to 10 VAS))

All Participants
Descriptive StatisticsBetween Arm Comparisons
Intervention A Intervention B
Day 1 after treatment
Mean
Mean Difference (MD)
SD
95% CI low (MD)
95% CI high (MD)
SD (MD)
p value (MD)
Day 7 after treatment
Mean
Mean Difference (MD)
SD
95% CI low (MD)
95% CI high (MD)
SD (MD)
p value (MD)
Day 4 after treatment
Mean
Mean Difference (MD)
SD
95% CI low (MD)
95% CI high (MD)
SD (MD)
p value (MD)
Within Arm ComparisonsNet Comparisons
Intervention A Intervention B

Persistent Opioid Use and Prescribing Rates (Opioid use (mean [SD] tablets))

All Participants
Descriptive StatisticsBetween Arm Comparisons
Intervention A Intervention B
After Treatment
Mean
Odds Ratio (OR)
SD
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
Intervention A Intervention B