Extraction form for project: Screening for Glaucoma in Adults - 1 of 2

Design Details

1. Study design

Arms

Arm NameArm Description
A. Timolol 0.5% twice daily (n=53)
B. Placebo (n=54)

Sample Characteristics

1. N
A. Timolol 0.5% twice daily (n=53)
B. Placebo (n=54)
Total
2. Baseline population
A. Timolol 0.5% twice daily (n=53)
B. Placebo (n=54)
Total

Outcomes

TypeDomainSpecific measurement (i.e., tool/definition/specific outcome)PopulationsTimepoints
CategoricalVision disorderVisual field progression (ITT)
  • All Participants
  • end of study
ContinuousHarm/adverse eventWithdrawal due to adverse events
  • All Participants
  • end of study

Risk of Bias Assessment

1. Random assignment
2. Allocation concealed
3. Groups similar at baseline
4. Eligibility criteria specified
5. Blinding: outcome assessors or data analysts
6. Intention-to-treat analysis
7. Reporting of attrition, contamination, etc.
8. Differential loss to followup or overall high loss to followup
9. Appropriate analysis including cluster correlation
10. Funding source
11. Randomization adequate?
12. Allocation concealment adequate?
13. Groups similar at baseline?
14. Eligibility criteria specified?
15. Outcome assessors masked?
16. Care provider masked?
17. Patient masked?
18. Attrition and withdrawals reported?
19. Loss to followup differential/ high?
20. People analyzed in the groups in which they were randomized?
21. Quality

Results

Categorical


Vision disorder (Visual field progression (ITT))

All Participants
Descriptive StatisticsBetween Arm Comparisons
A. Timolol 0.5% twice daily (n=53)B. Placebo (n=54)
vs.
end of study
Progression
Risk Ratio (RR)
Percentage
95% CI low (RR)
95% CI high (RR)
Risk Ratio, Adjusted (adjRR)
95% CI low (adjRR)
95% CI high (adjRR)
Within Arm ComparisonsNet Comparisons
A. Timolol 0.5% twice daily (n=53)B. Placebo (n=54)
vs.

Continuous


Harm/adverse event (Withdrawal due to adverse events)

All Participants
Descriptive StatisticsBetween Arm Comparisons
A. Timolol 0.5% twice daily (n=53)B. Placebo (n=54)
vs.
end of study
Percentage
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
Within Arm ComparisonsNet Comparisons
A. Timolol 0.5% twice daily (n=53)B. Placebo (n=54)
vs.