Extraction form for project: Screening for Glaucoma in Adults - 1 of 2

Design Details

1. Study design

Arms

Arm NameArm Description
A. Timolol 0.5% twice daily (n=46)
B. Placebo (n=44)

Sample Characteristics

1. N
A. Timolol 0.5% twice daily (n=46)
B. Placebo (n=44)
Total
2. Baseline population
A. Timolol 0.5% twice daily (n=46)
B. Placebo (n=44)
Total

Outcomes

TypeDomainSpecific measurement (i.e., tool/definition/specific outcome)PopulationsTimepoints
CategoricalVision disorderGlaucomatous field loss, 10 years
  • All Participants
  • 10 years
CategoricalVision disorderMean intraocular pressure (IOP) reduction
  • All Participants
  • end of study

Risk of Bias Assessment

1. Random assignment
2. Allocation concealed
3. Groups similar at baseline
4. Eligibility criteria specified
5. Blinding: outcome assessors or data analysts
6. Intention-to-treat analysis
7. Reporting of attrition, contamination, etc.
8. Differential loss to followup or overall high loss to followup
9. Appropriate analysis including cluster correlation
10. Funding source
11. Randomization adequate?
12. Allocation concealment adequate?
13. Groups similar at baseline?
14. Eligibility criteria specified?
15. Outcome assessors masked?
16. Care provider masked?
17. Patient masked?
18. Attrition and withdrawals reported?
19. Loss to followup differential/ high?
20. People analyzed in the groups in which they were randomized?
21. Quality

Results

Categorical


Vision disorder (Glaucomatous field loss, 10 years)

All Participants
Descriptive StatisticsBetween Arm Comparisons
A. Timolol 0.5% twice daily (n=46)B. Placebo (n=44)
All Arms (ANOVA)
10 years
mmHg
Risk Ratio (RR)
Total (N analyzed)
95% CI low (RR)
Events
95% CI high (RR)
Percentage
p value
Within Arm ComparisonsNet Comparisons
A. Timolol 0.5% twice daily (n=46)B. Placebo (n=44)
All Arms (ANOVA)

Vision disorder (Mean intraocular pressure (IOP) reduction)

All Participants
Descriptive StatisticsBetween Arm Comparisons
A. Timolol 0.5% twice daily (n=46)B. Placebo (n=44)
vs.
end of study
mmHg
p value
Within Arm ComparisonsNet Comparisons
A. Timolol 0.5% twice daily (n=46)B. Placebo (n=44)
vs.