Extraction form for project: Screening for Glaucoma in Adults - 1 of 2

Design Details

1. Study design

Arms

Arm NameArm Description
A. Timolol 0.5% (n=62 eyes)
B. Placebo (n=62 eyes) Fellow eye comparator

Sample Characteristics

1. N
A. Timolol 0.5% (n=62 eyes)
B. Placebo (n=62 eyes) Fellow eye comparator
Total
2. Baseline population
A. Timolol 0.5% (n=62 eyes)
B. Placebo (n=62 eyes) Fellow eye comparator
Total

Outcomes

TypeDomainSpecific measurement (i.e., tool/definition/specific outcome)PopulationsTimepoints
CategoricalVision disorderIOP, end of treatment
  • All Participants
  • end of study
CategoricalVision disorderGlaucomatous field changes
  • All Participants
  • end of study

Risk of Bias Assessment

1. Random assignment
2. Allocation concealed
3. Groups similar at baseline
4. Eligibility criteria specified
5. Blinding: outcome assessors or data analysts
6. Intention-to-treat analysis
7. Reporting of attrition, contamination, etc.
8. Differential loss to followup or overall high loss to followup
9. Appropriate analysis including cluster correlation
10. Funding source
11. Randomization adequate?
12. Allocation concealment adequate?
13. Groups similar at baseline?
14. Eligibility criteria specified?
15. Outcome assessors masked?
16. Care provider masked?
17. Patient masked?
18. Attrition and withdrawals reported?
19. Loss to followup differential/ high?
20. People analyzed in the groups in which they were randomized?
21. Quality

Results

Categorical


Vision disorder (IOP, end of treatment)

All Participants
Descriptive StatisticsBetween Arm Comparisons
A. Timolol 0.5% (n=62 eyes)B. Placebo (n=62 eyes) Fellow eye comparator
All Arms (ANOVA)
end of study
Total (N analyzed)
p value
Events
Percentage
Within Arm ComparisonsNet Comparisons
A. Timolol 0.5% (n=62 eyes)B. Placebo (n=62 eyes) Fellow eye comparator
All Arms (ANOVA)

Vision disorder (Glaucomatous field changes)

All Participants
Descriptive StatisticsBetween Arm Comparisons
A. Timolol 0.5% (n=62 eyes)B. Placebo (n=62 eyes) Fellow eye comparator
All Arms (ANOVA)
end of study
Total (N analyzed)
p value
Events
Percentage
Within Arm ComparisonsNet Comparisons
A. Timolol 0.5% (n=62 eyes)B. Placebo (n=62 eyes) Fellow eye comparator
All Arms (ANOVA)