Extraction form for project: Screening for Glaucoma in Adults - 1 of 2

Design Details

1. Study design

Arms

Arm NameArm Description
A. Latanaprostene bunod 0.024% four times per day
B. Timolol 0.5% twice per day

Sample Characteristics

1. N
A. Latanaprostene bunod 0.024% four times per day
B. Timolol 0.5% twice per day
Total
2. Baseline population
A. Latanaprostene bunod 0.024% four times per day
B. Timolol 0.5% twice per day
Total

Outcomes

TypeDomainSpecific measurement (i.e., tool/definition/specific outcome)PopulationsTimepoints
CategoricalVision disorderProportion with ≥25% reduction in intraocular pressure (IOP) at all time points
  • All Participants
  • end of study
CategoricalVision disorderProportion with mean intraocular pressure (IOP) ≤18 mmHg at all time points
  • All Participants
  • end of study
ContinuousHarm/adverse eventWithdrawal due to adverse events
  • All Participants
  • end of study

Risk of Bias Assessment

1. Random assignment
2. Allocation concealed
3. Groups similar at baseline
4. Eligibility criteria specified
5. Blinding: outcome assessors or data analysts
6. Intention-to-treat analysis
7. Reporting of attrition, contamination, etc.
8. Differential loss to followup or overall high loss to followup
9. Appropriate analysis including cluster correlation
10. Funding source
11. Randomization adequate?
12. Allocation concealment adequate?
13. Groups similar at baseline?
14. Eligibility criteria specified?
15. Outcome assessors masked?
16. Care provider masked?
17. Patient masked?
18. Attrition and withdrawals reported?
19. Loss to followup differential/ high?
20. People analyzed in the groups in which they were randomized?
21. Quality

Results

Categorical


Vision disorder (Proportion with ≥25% reduction in intraocular pressure (IOP) at all time points)

All Participants
Descriptive StatisticsBetween Arm Comparisons
A. Latanaprostene bunod 0.024% four times per dayB. Timolol 0.5% twice per day
vs.
end of study
Percentage
Difference of proportions (95% CI)
p value
Within Arm ComparisonsNet Comparisons
A. Latanaprostene bunod 0.024% four times per dayB. Timolol 0.5% twice per day
vs.

Vision disorder (Proportion with mean intraocular pressure (IOP) ≤18 mmHg at all time points)

All Participants
Descriptive StatisticsBetween Arm Comparisons
A. Latanaprostene bunod 0.024% four times per dayB. Timolol 0.5% twice per day
vs.
end of study
Percentage
p value
Within Arm ComparisonsNet Comparisons
A. Latanaprostene bunod 0.024% four times per dayB. Timolol 0.5% twice per day
vs.

Continuous


Harm/adverse event (Withdrawal due to adverse events)

All Participants
Descriptive StatisticsBetween Arm Comparisons
A. Latanaprostene bunod 0.024% four times per dayB. Timolol 0.5% twice per day
vs.
end of study
Percentage
Relative risk (RR) (95% CI)
Within Arm ComparisonsNet Comparisons
A. Latanaprostene bunod 0.024% four times per dayB. Timolol 0.5% twice per day
vs.