Extraction form for project: ESP Troponin ADPs

Design Details

1. Cohort name
Cohort, not ADP, name
2. Protocol number (eg, NCT)
3. Copublications
List other records that were extracted with this primary articles. Eg, PMIDs or other identifiers
4. Study design
5. Study years
Just years. Not publication year. Years of study. You may need to estimate. Use tilde (~) if you're approximating. If not reported, put "< ####" (the publication or submission year).
StartEnd
6. Funding
Include provision of materials (eg, cTn labs) from industry as industry funding
7. Country/ies
NR should rarely if ever be selected
8. Setting
9. Centers
If Unclear, add a note why
10. Inclusion criteria
ACS row = Eligibility criteria specific to acute coronary syndrome symptoms/signs. Age/Gender = criteria specific to age/gender. Prior CVD = restriction based on prior cardiovascular disease, event, or procedure. Other = other inclusion criteria. Skip rows that do not pertain. Be concise.
ACS
Age
Gender
Prior CVD
Other
11. Exclusion criteria
Prior CVD = exclusion based on prior cardiovascular disease, event, or procedure. Other = other exclusion criteria. Skip rows that do not pertain. Be concise.
STEMI
Prior CVD
Comorbidity
Other
12. Special/Atypical population
Highlight if this is a specific group of patients. Skip if no particular relevant exclusion criteria
13. Comments/Notes

Arms

Arm NameArm Description
not hs-cTn Pre-implementation: Hs-cTn or conventional cTn at 0h, and after 3 to 9 hrs (if MI was still suspected) + clinical assessment + ECG.
hs-cTnPost-implementation: Modified hs-cTn 1h algorithm + HEART score

Arm Details

1. hs-cTn info
Click NR checkboxes in each row with no reported data
not hs-cTn
DataNR
Test name
Manufacturer
Generation
Limit of detection (ng/L)
Comment/Note
99th %ile
hs-cTn
DataNR
Test name
Manufacturer
Generation
Limit of detection (ng/L)
Comment/Note
99th %ile

Sample Characteristics

1. N Enrolled
2. Age
3. % Male
4. Race/Ethnicity, %
White
White, Non-Hispanic
Black
Hispanic/Latino
Asian (any)
East Asian
South Asian
Other 1
Other 2
Other 3
NR
5. Are there significant differences (statistical or clinical) between the two groups?
6. History of Cardiovascular Disease, %
peripheral arterial disease
Stroke/TIA
Prior MI
prior revascularization (eg., CABG, PCI)
History of Cardiovascular Disease
7. Risk Factors for Cardiovascular Disease, %
Comments
Hypertension
Diabetes
Smoking Histrory
BMI/obesity
Family History
Hyperlipidemia
8. Risk Score
Enter risk score name (eg Heart), mean (SD) or thresholds and proportions
Name Risk ScoreThresholdProportion, %Mean (SD)Comment
Risk Score 1
Risk Score 2
Risk Score 3
Risk Score 4
9. Notes/Comments

Outcomes

TypeDomainSpecific measurement (i.e., tool/definition/specific outcome)PopulationsTimepoints
CategoricalHospitalizationAdmission to hospital
  • All Participants
  • HEART score ≤3
  • HEART score ≥4
  • hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
  • hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
  • ED visit
CategoricalReturn to ED or hospitalReadmission to hospital
  • All Participants
  • Patients admitted to hospital
  • Patients discharged from the ED
  • HEART score ≤3
  • HEART score ≥4
  • hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
  • hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
  • 30 (d)
CategoricalReturn to ED or hospitalNew presentation to the ED
  • All Participants
  • Patients admitted to hospital
  • Patients discharged from the ED
  • HEART score ≤3
  • HEART score ≥4
  • hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
  • hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
  • 30 (d)
CategoricalMI, missed/delayedMyocardial infarction after discharge
  • All Participants
  • Patients admitted to hospital
  • Patients discharged from the ED
  • HEART score ≤3
  • HEART score ≥4
  • hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
  • -cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
  • 30 (d)
CategoricalDeath, all-causeDeath after discharge
  • All Participants
  • Patients admitted to hospital
  • Patients discharged from the ED
  • HEART score ≤3
  • HEART score ≥4
  • hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
  • hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
  • 30 (d)
CategoricalMI, anyIn-hospital MI
  • Patients admitted to hospital
  • HEART score ≤3
  • HEART score ≥4
  • hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
  • hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
  • In-hospital stay
CategoricalDelayed interventionUnplanned revascularization (A new presentation to the ED, followed by admission and revascularization)
  • All Participants
  • Patients admitted to hospital
  • Patients discharged from the ED
  • HEART score ≤3
  • HEART score ≥4
  • hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
  • hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
  • 30 (d)
CategoricalDeath, all-causeIn-hospital death
  • Patients admitted to hospital
  • HEART score ≤3
  • HEART score ≥4
  • hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
  • hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
  • In-hospital stay
CategoricalCardiac testingEchocardiography
  • All Participants
  • 30 (d)
CategoricalCardiac testingExercise ECG test
  • All Participants
  • 30 (d)
CategoricalCardiac testingCoronary angiography
  • All Participants
  • 30 (d)
CategoricalCardiac testingMyocardial scintigraphy
  • All Participants
  • 30 (d)
CategoricalCardiac testingStress echocardiography
  • All Participants
  • 30 (d)
CategoricalCardiac testingAny stress test (includes exercise ECG test, myocardial scintigraphy, and stress electrocardiography)
  • All Participants
  • HEART score ≤3
  • HEART score ≥4
  • hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
  • hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
  • 30 (d)
CategoricalCardiac testingPCI and coronary angiography
  • All Participants
  • 30 (d)
CategoricalCardiac testingCABG
  • All Participants
  • 30 (d)
CategoricalCardiac testingCT heart
  • All Participants
  • 30 (d)
CategoricalCardiac testingMRI heart
  • All Participants
  • 30 (d)
CategoricalCardiac testingAny test for ischemia (ncludes exercise ECG test, myocardial scintigraphy, stress echocardiography, CT of the heart, coronary angiography, PCI, and CABG)
  • All Participants
  • HEART score ≤3
  • HEART score ≥4
  • hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
  • hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
  • 30 (d)
ContinuousED Visit durationTime to discharge, h
  • All Participants
  • Patients admitted to hospital
  • Patients discharged from the ED
  • HEART score ≤3
  • HEART score ≥4
  • hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
  • hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
  • ED visit (h)
CategoricalImplementation / Adherence Adherence to the decision algorithm
  • All Participants
  • Baseline

Outcome Details

1. MI definition
Universal definitions refer to ESC/ACC/AHA/WHF (or Global MI) task forces. If an Other definition, provide details in 2nd row and the cited reference for their definition in the 3rd row.
Hospitalization
Universal
Other
Other reference
Return to ED or hospital
Universal
Other
Other reference
Return to ED or hospital
Universal
Other
Other reference
MI, missed/delayed
Universal
Other
Other reference
Death, all-cause
Universal
Other
Other reference
MI, any
Universal
Other
Other reference
Delayed intervention
Universal
Other
Other reference
Death, all-cause
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
ED Visit duration
Universal
Other
Other reference
Implementation / Adherence
Universal
Other
Other reference
2. MACE components
If a checked component has an asterisk (*), confirm with team before extracting the MACE outcome
Hospitalization
Return to ED or hospital
Return to ED or hospital
MI, missed/delayed
Death, all-cause
MI, any
Delayed intervention
Death, all-cause
Cardiac testing
Cardiac testing
Cardiac testing
Cardiac testing
Cardiac testing
Cardiac testing
Cardiac testing
Cardiac testing
Cardiac testing
Cardiac testing
Cardiac testing
ED Visit duration
Implementation / Adherence

Results

Categorical


Hospitalization (Admission to hospital)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
ED visit
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
HEART score ≤3
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
ED visit
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
HEART score ≥4
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
ED visit
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
ED visit
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
ED visit
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Return to ED or hospital (Readmission to hospital)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
Patients admitted to hospital
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
Patients discharged from the ED
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
HEART score ≤3
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
HEART score ≥4
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Return to ED or hospital (New presentation to the ED)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
Patients admitted to hospital
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
Patients discharged from the ED
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
HEART score ≤3
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
HEART score ≥4
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

MI, missed/delayed (Myocardial infarction after discharge)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
Patients admitted to hospital
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
Patients discharged from the ED
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
HEART score ≤3
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
HEART score ≥4
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Death, all-cause (Death after discharge)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
Patients admitted to hospital
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
Patients discharged from the ED
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
HEART score ≤3
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
HEART score ≥4
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

MI, any (In-hospital MI)

Patients admitted to hospital
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
All Arms (ANOVA)
In-hospital stay
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
All Arms (ANOVA)
HEART score ≤3
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
In-hospital stay
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
HEART score ≥4
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
In-hospital stay
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
In-hospital stay
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
In-hospital stay
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Delayed intervention (Unplanned revascularization (A new presentation to the ED, followed by admission and revascularization))

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
Patients admitted to hospital
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
Patients discharged from the ED
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
HEART score ≤3
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
HEART score ≥4
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Death, all-cause (In-hospital death)

Patients admitted to hospital
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
All Arms (ANOVA)
In-hospital stay
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
All Arms (ANOVA)
HEART score ≤3
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
In-hospital stay
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
HEART score ≥4
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
In-hospital stay
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
In-hospital stay
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
In-hospital stay
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Cardiac testing (Echocardiography)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)

Cardiac testing (Exercise ECG test)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)

Cardiac testing (Coronary angiography)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)

Cardiac testing (Myocardial scintigraphy)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)

Cardiac testing (Stress echocardiography)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)

Cardiac testing (Any stress test (includes exercise ECG test, myocardial scintigraphy, and stress electrocardiography))

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
HEART score ≤3
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
HEART score ≥4
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-cTnT >14 ng/L hs-cTnI ≥35 ng/L (♂) hs-cTnI ≥16 ng/L (♀)
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Cardiac testing (PCI and coronary angiography)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)

Cardiac testing (CABG)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)

Cardiac testing (CT heart)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Cardiac testing (MRI heart)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)

Cardiac testing (Any test for ischemia (ncludes exercise ECG test, myocardial scintigraphy, stress echocardiography, CT of the heart, coronary angiography, PCI, and CABG))

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
30 (d)
Total (N analyzed)
Risk Ratio (RR)
Events
95% CI low (RR)
Percentage
95% CI high (RR)
Note
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (...)
vs.
hs-cTn (Post-implemen...)
HEART score ≤3
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
HEART score ≥4
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
hs-TnT Δ ≥3 ng/L hs-TnI Δ ≥6 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Odds Ratio (OR)
Events
95% CI low (OR)
Percentage
95% CI high (OR)
Note
Risk Ratio (RR)
95% CI low (RR)
95% CI high (RR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTn