Extraction form for project: ESP Troponin ADPs

Design Details

1. Cohort name
Cohort, not ADP, name
2. Protocol number (eg, NCT)
3. Copublications
List other records that were extracted with this primary articles. Eg, PMIDs or other identifiers
4. Study design
5. Study years
Just years. Not publication year. Years of study. You may need to estimate. Use tilde (~) if you're approximating. If not reported, put "< ####" (the publication or submission year).
StartEnd
6. Funding
Include provision of materials (eg, cTn labs) from industry as industry funding
7. Country/ies
NR should rarely if ever be selected
8. Setting
9. Centers
If Unclear, add a note why
10. Inclusion criteria
ACS row = Eligibility criteria specific to acute coronary syndrome symptoms/signs. Age/Gender = criteria specific to age/gender. Prior CVD = restriction based on prior cardiovascular disease, event, or procedure. Other = other inclusion criteria. Skip rows that do not pertain. Be concise.
ACS
Age
Gender
Prior CVD
Other
11. Exclusion criteria
Prior CVD = exclusion based on prior cardiovascular disease, event, or procedure. Other = other exclusion criteria. Skip rows that do not pertain. Be concise.
STEMI
Prior CVD
Comorbidity
Other
12. Special/Atypical population
Highlight if this is a specific group of patients. Skip if no particular relevant exclusion criteria
13. Comments/Notes

Arms

Arm NameArm Description
not hs-cTn0/3-h hs-cTnT protocol/Standard masked hs-cTnT (chest pain protocol): lower limit reported at the same level of contemporary cTn): Hs-cTnT 0/3-h + ECG + clinical assessment + history + various risk scores not mandated (EDACS, GRACE, TIMI, HEART)
hs-cTn0/1-h hs-cTnT protocol: Hs-cTnT at 0, 1h + History + ECG + various risk score (EDACS, GRACE, TIMI, HEART)

Arm Details

1. hs-cTn info
Click NR checkboxes in each row with no reported data
not hs-cTn
DataNR
Test name
Manufacturer
Generation
Limit of detection (ng/L)
Comment/Note
99th %ile
hs-cTn
DataNR
Test name
Manufacturer
Generation
Limit of detection (ng/L)
Comment/Note
99th %ile

Sample Characteristics

1. N Enrolled
2. Age
3. % Male
4. Race/Ethnicity, %
White
White, Non-Hispanic
Black
Hispanic/Latino
Asian (any)
East Asian
South Asian
Other 1
Other 2
Other 3
NR
5. Are there significant differences (statistical or clinical) between the two groups?
6. History of Cardiovascular Disease, %
peripheral arterial disease
Stroke/TIA
Prior MI
prior revascularization (eg., CABG, PCI)
History of Cardiovascular Disease
7. Risk Factors for Cardiovascular Disease, %
Comments
Hypertension
Diabetes
Smoking Histrory
BMI/obesity
Family History
Hyperlipidemia
8. Risk Score
Enter risk score name (eg Heart), mean (SD) or thresholds and proportions
Name Risk ScoreThresholdProportion, %Mean (SD)Comment
Risk Score 1
Risk Score 2
Risk Score 3
Risk Score 4
9. Notes/Comments

Outcomes

TypeDomainSpecific measurement (i.e., tool/definition/specific outcome)PopulationsTimepoints
ContinuousED Visit durationLength of stay in ED, h, median (IQR)
  • All Participants
  • Participants with initial troponin T ≤29 ng/L
  • Among MI observe subgroup
  • ED visit (h)
ContinuousED Visit durationAcute care length of stay, h, median (IQR)
  • All Participants
  • Participants with initial troponin T ≤29 ng/L
  • ED visit (h)
CategoricalCardiac testingStress echocardiogram
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalCardiac testingExercise stress test within 30 days
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalCardiac testingCardiac MRI
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalCardiac testingFunctional testing
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • Initial hs-TnT < 5 ng/L
  • Initial hs-TnT 5-29 ng/L
  • Initial hs-TnT > 30 ng/L
  • MI Observe subset
  • 30 (d)
CategoricalCardiac testingCoronary angiogram
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • Initial hs-TnT < 5 ng/L
  • Initial hs-TnT 5-29 ng/L
  • Initial hs-TnT > 30 ng/L
  • MI Observe subset
  • 30 (d)
CategoricalCardiac testingCT coronary angiogram
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalCardiac testingEchocardiogram
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalCardiac revascularizationPercutaneous coronary intervention
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalCardiac revascularizationCoronary artery bypass grafting
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalCardiac revascularizationAny coronary revascularization
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • Initial hs-TnT < 5 ng/L
  • Initial hs-TnT 5-29 ng/L
  • Initial hs-TnT > 30 ng/L
  • MI Observe subset
  • 30 (d)
CategoricalDeath, all-cause
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalCardiovascular death
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalMI, anyMyocardial infarction (type 1, type2, type 4a, type 5)
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalMI, anyAcute myocardial injury with/without revascularization
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalMACEDeath or myocardial infarction
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalMACEUnstable angina
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalMACEMyocardial infarction or myocardial injury (Acute)
  • All Participants
  • Participants with initial troponin T ≤29 ng/L
  • MI Observe subset
  • 30 (d)
CategoricalMACECardiovascular death, myocardial infarction, and unstable angina
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalHospitalizationDischarged from ED
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • ED visit
CategoricalReturn to ED or hospitalRe-presentation with chronic myocardial injury pattern
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalReturn to ED or hospitalCardiovascular rehospitalization
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)
CategoricalReturn to ED or hospitalChest pain re-presentation
  • All Participants
  • Participants with initial troponin T ≤29 ng/L,
  • MI Observe subset
  • 30 (d)

Outcome Details

1. MI definition
Universal definitions refer to ESC/ACC/AHA/WHF (or Global MI) task forces. If an Other definition, provide details in 2nd row and the cited reference for their definition in the 3rd row.
ED Visit duration
Universal
Other
Other reference
ED Visit duration
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac testing
Universal
Other
Other reference
Cardiac revascularization
Universal
Other
Other reference
Cardiac revascularization
Universal
Other
Other reference
Cardiac revascularization
Universal
Other
Other reference
Death, all-cause
Universal
Other
Other reference
Cardiovascular death
Universal
Other
Other reference
MI, any
Universal
Other
Other reference
MI, any
Universal
Other
Other reference
MACE
Universal
Other
Other reference
MACE
Universal
Other
Other reference
MACE
Universal
Other
Other reference
MACE
Universal
Other
Other reference
Hospitalization
Universal
Other
Other reference
Return to ED or hospital
Universal
Other
Other reference
Return to ED or hospital
Universal
Other
Other reference
Return to ED or hospital
Universal
Other
Other reference
2. MACE components
If a checked component has an asterisk (*), confirm with team before extracting the MACE outcome
ED Visit duration
ED Visit duration
Cardiac testing
Cardiac testing
Cardiac testing
Cardiac testing
Cardiac testing
Cardiac testing
Cardiac testing
Cardiac revascularization
Cardiac revascularization
Cardiac revascularization
Death, all-cause
Cardiovascular death
MI, any
MI, any
MACE
MACE
MACE
MACE
Hospitalization
Return to ED or hospital
Return to ED or hospital
Return to ED or hospital

Results

Categorical


Cardiac testing (Stress echocardiogram)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Participants with initial troponin T ≤29 ng/L,
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
MI Observe subset
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Cardiac testing (Exercise stress test within 30 days)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Participants with initial troponin T ≤29 ng/L,
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
MI Observe subset
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Cardiac testing (Cardiac MRI )

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Participants with initial troponin T ≤29 ng/L,
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
MI Observe subset
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Cardiac testing (Functional testing)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Participants with initial troponin T ≤29 ng/L,
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
Initial hs-TnT < 5 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Initial hs-TnT 5-29 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
Initial hs-TnT > 30 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
MI Observe subset
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Cardiac testing (Coronary angiogram)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Participants with initial troponin T ≤29 ng/L,
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
Initial hs-TnT < 5 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Initial hs-TnT 5-29 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
Initial hs-TnT > 30 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
MI Observe subset
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Cardiac testing (CT coronary angiogram)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Participants with initial troponin T ≤29 ng/L,
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
MI Observe subset
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Cardiac testing (Echocardiogram )

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Participants with initial troponin T ≤29 ng/L,
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
MI Observe subset
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Cardiac revascularization (Percutaneous coronary intervention)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Participants with initial troponin T ≤29 ng/L,
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
MI Observe subset
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Cardiac revascularization (Coronary artery bypass grafting)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Participants with initial troponin T ≤29 ng/L,
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
MI Observe subset
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Cardiac revascularization (Any coronary revascularization)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Participants with initial troponin T ≤29 ng/L,
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
Initial hs-TnT < 5 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Initial hs-TnT 5-29 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
Initial hs-TnT > 30 ng/L
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
MI Observe subset
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Death, all-cause

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Participants with initial troponin T ≤29 ng/L,
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
MI Observe subset
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

Cardiovascular death

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Participants with initial troponin T ≤29 ng/L,
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
MI Observe subset
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

MI, any (Myocardial infarction (type 1, type2, type 4a, type 5))

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Participants with initial troponin T ≤29 ng/L,
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
MI Observe subset
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

MI, any (Acute myocardial injury with/without revascularization)

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
Participants with initial troponin T ≤29 ng/L,
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
vs.
30 (d)
Total (N analyzed)
Interaction p value
Events
Noninferiority P Value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
Incidence Rate Ratio (IRR)
95% CI low (IRR)
95% CI high (IRR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn
vs.
MI Observe subset
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
30 (d)
Total (N analyzed)
Noninferiority P Value
Events
Interaction p value
Percentage
Odds Ratio (OR)
95% CI low (OR)
95% CI high (OR)
p value
Within Arm ComparisonsNet Comparisons
not hs-cTnhs-cTn

MACE (Death or myocardial infarction )

All Participants
Descriptive StatisticsBetween Arm Comparisons
not hs-cTnhs-cTn
not hs-cTn (0/3-h hs-cTnT...)
vs.
hs-cTn (0/1-h hs-cTnT...)
30 (d)
Total (N analyzed)
Noninferiority P Value
Events